A5090566838- Inflammatory Bowel Disease
- Ophthalmology and Eye Disorders
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Thyroid Disorders and Treatments
- Statistical Methods in Clinical Trials
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Dysphagia Assessment and Management
- Statistical Methods and Bayesian Inference
- Viral gastroenteritis research and epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Neurological Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Ocular Oncology and Treatments
- Respiratory viral infections research
- Erythrocyte Function and Pathophysiology
- Clinical Nutrition and Gastroenterology
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Clusterin in disease pathology
- Phagocytosis and Immune Regulation
Shandong First Medical University
2025
XinHua Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Institute of Nutrition and Health
2022-2024
Second Affiliated Hospital of Nanchang University
2011-2024
Nanchang University
2011-2024
Cohen Children's Medical Center
2013-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022-2023
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2021-2022
Ministry of Public Health
2013-2019
OBJECTIVES: Patients with inflammatory bowel disease (IBD) frequently receive immunosuppressive therapy. The immune response in these patients to vaccines has not been well studied. We conducted a prospective, open label study evaluate the serologic influenza vaccine children IBD. METHODS: Serum was obtained from 146 and young adults IBD (96 Crohn's disease, 47 ulcerative colitis, 3 indeterminate colitis) for baseline titer, immediately followed by immunization trivalent (A/Solomon...
The authors found that cost-related medication nonadherence was prevalent among patients with cancer who sought financial assistance.
<h3>Objectives</h3> To study 11 patients with melanoma-associated retinopathy (MAR) to clarify the reliability of various methods diagnostic testing, determine underlying antigenic retinal proteins, and clinical histories types associated melanomas. <h3>Methods</h3> Clinical data were obtained from melanoma who developed marked visual problems. Testing included electroretinography, kinetic fields, comparative studies Western blots, indirect immunohistologic examination detect antiretinal...
Thyroglobulin (Tg) is the macromolecular precursor of thyroid hormones and thought to be uniquely expressed by epithelial cells. Tg thyroid-stimulating hormone receptor (TSHR) are targets for autoantibody generation in autoimmune disorder Graves disease (GD). Fully GD characterized overactivity orbital tissue inflammation remodeling. This process known as thyroid-associated ophthalmopathy (TAO). Early reports suggested that TAO, both TSHR become overexpressed tissues. Previously, we found...
The molecular basis for anatomically dispersed clinical manifestations in Graves' disease (GD) eludes our understanding. Bone marrow-derived, pluripotent fibrocytes represent a subset of peripheral blood mononuclear cells and infiltrate the orbital thyroid tissues GD. These may be involved pathogenesis thyroid-associated ophthalmopathy (TAO).The objective study was to quantify fibrocyte display functional cell surface TSH receptor (TSHR), identify profile chemokines they express after TSHR...
Female patients receiving immunosuppressive therapy may be at increased risk for human papillomavirus (HPV) infection and cervical neoplasia.We administered the 3-dose HPV vaccine Gardasil to 37 females aged 9 26 years with inflammatory bowel disease (IBD) prescribed (prospective cohort). Geometric mean titers (GMT) in milli-Merck (mMu/mL) units were determined before dose 1 month after 3 by competitive Luminex immunoassay (cLIA) qualitatively compared healthy of similar age from Merck's...
Purpose.: CD40–CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow–derived progenitor cells. The functional consequences of ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO). Methods.: levels cultivated fibrocytes orbital fibroblasts (GOFB) from patients Graves' disease (GD), as well fibrocyte abundance, were by...
CD34(+) fibrocytes, bone marrow-derived progenitor cells, infiltrate orbital connective tissue in thyroid-associated ophthalmopathy, a manifestation of Graves' disease. In the orbit, they become fibroblasts and coexist with native CD34(-) fibroblasts. Fibrocytes have been shown to express TSH receptor thyroglobulin.The objective study was determine whether broader repertoire thyroid protein expression can be detected fibrocytes common factor is responsible.Fibrocytes were collected analyzed...
Background. Few population-based estimates of the incidence respiratory syncytial virus (RSV) infection in low- or middle-income countries are available. We describe and epidemiology hospitalizations for RSV-associated acute lower tract (ALRI) detected by active surveillance 2 rural Thailand provinces during 2008–2011. Methods. Patients hospitalized with ALRI were systematically sampled. Consenting patients provided nasopharyngeal swab specimens RSV testing real-time reverse-transcription...
Graves' disease (GD) is a systemic autoimmune syndrome comprising manifestations in thyroid and orbital connective tissue. The link between these two tissues GD eludes our understanding. Patients with have increased frequency of circulating monocyte lineage cells known as fibrocytes. These fibrocytes infiltrate thyroid-associated ophthalmopathy express functional TSH receptor (TSHR). aim the study was to identify characterize CD34+ undergoing surgical thyroidectomy at academic medical...
Abstract Background The incidence of very early onset inflammatory bowel disease (VEOIBD) is increasing, yet the phenotype and natural history VEOIBD are not well described. Methods We performed a retrospective cohort study patients diagnosed with (6 years age younger) between 2008 2013 at 25 North American centers. Eligible each center were randomly selected for chart review. abstracted data diagnosis 1, 3, 5 after diagnosis. compared clinical features outcomes younger than 3 children to 6...
ABSTRACT Children and adolescents with inflammatory bowel disease (IBD) receiving therapy tumor necrosis factor α inhibitors (anti‐TNFα) pose a unique challenge to health care providers in regard the associated risk of infection. Published experience adult populations distinct autoinflammatory autoimmune diseases treated anti‐TNFα therapies demonstrates an increased serious infections intracellular bacteria, mycobacteria, fungi, some viruses; however, there is paucity robust pediatric data....
Background/Objectives: With the advancement of intelligent sensing technology, rehabilitation systems based on wearable devices have a positive impact functional recovery and quality life stroke patients. This study aims to evaluate application value contextualized training system for survivors, which is devices, in motor function impairments following stroke. Methods: A randomized controlled trial design was employed, 100 patients were randomly divided into control group (n = 50, receiving...
Short bowel syndrome (SBS) is a condition characterized by malabsorption that occurs when patient loses significant amount of length or function, often necessitating lifelong parenteral nutrition support. This study utilized multi-omics analysis to investigate alterations in gut microbiota, metabolism, and transcriptome during the progression intestinal adaptation SBS using piglet model. We established model Bama mini piglets performing 75% jejunoileal resection. Fifteen were randomized into...
Verification bias arises in diagnostic test evaluation studies when the results from a first are verified by reference only non-representative subsample of original study subjects. This occurs, for example, inclusion probabilities depend on first-stage and/or covariate related to disease status. Reference standard itself has imperfect sensitivity and specificity, but this information is ignored analysis. typically underestimation specificity under evaluation, since subjects that correctly...
We aimed to determine vaccination practices of pediatric gastroenterologists, as well barriers following immunization guidelines in patients with inflammatory bowel disease.Institutions listed the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition clinical research registry and/or ImproveCareNow were contacted. A total 657 physicians from 129 institutions asked complete a 16-question electronic survey.A 178 (27.1%) responded, whom 55% male 83.1% practiced an...
Background: Research on the utilization and effectiveness of antitumor necrosis factor (TNF) biologics in children with very early onset inflammatory bowel disease (VEOIBD) is urgently needed. Here we describe anti-TNF use durability a multicenter cohort. Methods: We performed retrospective cohort study patients diagnosed VEOIBD (<6 years) between 2008 2013 at 25 North American centers. chart abstraction diagnosis 1, 3, 5 years after diagnosis. examined rate initiation infliximab...
Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia manifested by multiple enchondromas and hemangiomas. It associated with diverse secondary musculoskeletal deformities, which exceedingly rare. We report case of hemangiomas localized in the unilateral limb patient syndrome. Treatment consists orthopedic surgical intervention to minimize deformities for cosmetic purpose. Careful surveillance malignant degeneration both skeletal non-skeletal tumors, especially brain...
In the last two decades, single-arm trials (SATs) have been effectively used to study anticancer therapies in well-defined patient populations using durable response rates as an objective and interpretable endpoints. With a growing trend of regulatory accelerated approval (AA) requiring randomized controlled (RCTs), some confusions arisen about roles SATs AA. This review is intended elucidate necessary desirable conditions under which SAT may be considered appropriate for Specifically, paper...
Bufalin (BU) is a bioactive ingredient extracted from the skin and parotid venom glands of Bufo raddei, which can effectively inhibit angiogenesis. The aim this study was to investigate whether BU could affect corneal neovascularization (CoNV).