A5061920772- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Gut microbiota and health
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Liver Diseases and Immunity
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Celiac Disease Research and Management
- Biosimilars and Bioanalytical Methods
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Hidradenitis Suppurativa and Treatments
- Chronic Lymphocytic Leukemia Research
- Drug Transport and Resistance Mechanisms
- Diagnosis and treatment of tuberculosis
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Anorectal Disease Treatments and Outcomes
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Treatments and Studies
University of Chicago
2016-2025
University of Chicago Medical Center
2013-2021
Sunderland Royal Hospital
2013
Louisiana State University in Shreveport
2005
Louisiana State University Health Sciences Center Shreveport
2005
Dartmouth College
2001-2003
Tufts University
1996
Abstract Background: The mammalian target of rapamycin (mTOR) regulates multiple cellular functions including translation in response to nutrients, especially amino acids. AMP‐activated protein kinase (AMPK) modulates metabolism energy demand by responding changes AMP. Results: treatment SV40‐immortalized human corneal epithelial cells (HCE‐T cells) with 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICAR), widely used as an AMPK activator, inhibits p70 S6k activities. Altered glucose...
The importance of admission physiological and biochemical variables was modeled on data from 185 patients with blunt liver trauma regard to their significance in prediction mortality. used were Glasgow Coma Score, base excess (or deficit), arterial lactate, Injury Severity initial 24-hour volume blood required for replacement. Each variable as a predictor survival alone combination, using linear logistic model. In any two-variable Score had high likelihood ratio representing the influence...
Colonic microbiota ferment non-absorbed dietary fiber to produce prodigious amounts of short chain fatty acids (SCFAs) that benefit the host through a myriad metabolic, trophic, and chemopreventative effects. The effects SCFA butyrate are, in part, mediated induction p21 gene expression. In this study, we assessed role microRNA(miRNA) butyrate's expression profiles miRNAs HCT-116 cells human sporadic colon cancers were by microarray quantitative PCR. Regulation miR-106b was 3' UTR luciferase...
Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions. Reshaping intestinal through pharmacologic means may be a viable treatment option. We sought to delineate the functional characteristics of glucocorticoid-mediated alterations on their subsequent repercussions host mucin regulation colonic inflammation.
Mucosal biopsy is the most common sampling technique used to assess microbial communities associated with intestinal mucosa. Biopsies disrupt epithelium and can be complications such as bleeding. sample a limited area of mucosa, which lead potential bias. In contrast mucosal biopsy, brush less invasive provides greater coverage, if it provide equivalent community data, would preferable biopsies. We compared samples collected from mucosa using either cytology or forceps. paired patients...
Objectives: Vedolizumab is increasingly used to treat patients with ulcerative colitis (UC) and Crohn’s disease (CD), however, its safety during the perioperative period remains unclear. We compared 30-day postoperative complications among treated preoperatively vedolizumab, anti-tumor necrosis factor (TNF)-α agents or non-biological therapy. Methods: The retrospective study cohort was comprised of receiving anti-TNF-α therapy within 4 weeks surgery. rates were between groups using...
This study reports the clinical and sonographic outcome of arthroscopic rotator cuff repair in patients aged ≥ 70 years aimed to determine factors associated with re-tear. A total 69 consecutive repairs were performed 68 a mean age 77 (70 86). Constant-Murley scores collected pre-operatively at one year post-operatively. The integrity was assessed using ultrasound. Re-tear detected 20 62 (32%) Age operation significantly re-tear free survival (p = 0.016). pre-operative Constant score 23 (sd...
Secukinumab, an interleukin (IL)-17A antagonist, was associated with disease exacerbations in Crohn's disease, and de novo cases of inflammatory bowel (IBD) have been reported studies rheumatoid diseases. However, there has no detailed report demonstrating the linkage between secukinumab therapy new-onset IBD. We present a unique case rapid-onset fulminant colitis after receiving 1 dose infusion followed by improvement combination antibiotics, corticosteroids, calcineurin inhibition. Health...
Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient absorption, regulate host metabolic processes, influence physiology of the gut microbiota. Both its microbiome contribute to enzymatic modifications shape chemical diversity BAs gut. Several bacterial species have been reported conjugate standard amino BAs, but it was not known if bacteria other amine classes. Here, we show
The AMP‐activated protein kinase (AMPK) is a heterotrimeric composed of catalytic α subunit and two regulatory subunits, β γ. γ essential for enzyme activity by virtue its binding to the C‐terminus appears play some role in determination AMP sensitivity. We demonstrate that γ1R70Q mutation causes marked increase AMPK renders it largely AMP‐independent. This activation associated with increased phosphorylation loop T172. These vitro characteristics are also reflected intracellular one major...
Clinical and endoscopic recurrence are common after surgery in Crohn's disease (CD). Vedolizumab has been increasingly used to treat CD, however, its effectiveness preventing postoperative remains unknown. We aimed investigate the use of vedolizumab setting compare risk between patients receiving anti-tumor necrosis factor (TNF)-α agents. Medical records CD who underwent April 2014 June 2016 were reviewed. first analyzed how frequently is prevent compared patient characteristics with those...
ABSTRACT A 2-year longitudinal microbiome study of 22 patients who underwent colectomy with an ileal pouch anal anastomosis detected significant increases in distinct populations Bacteroides during 9 11 patient visits that coincided inflammation (pouchitis). Oligotyping and metagenomic short-read annotation identified occurred early samples, bloomed inflammation, reappeared after antibiotic treatment. Targeted cultivation isolates from the same individual at multiple time points several...
Summary Background Following induction therapy with a calcineurin inhibitor (CNI) in severe ulcerative colitis, transitioning to vedolizumab as maintenance could be an option. Aim To report on the largest cohort of patients successfully induced CNIs who were transitioned therapy. Methods This is retrospective observational study adult steroid‐refractory colitis. Patients included if they CNI followed by between January 2014 and December 2018. The primary endpoint was colectomy‐free survival....
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas pouches using scRNA-seq scATAC-seq data from paired biopsy samples segment above (pre-pouch) (male=4, female=2), biopsies terminal ileum ascending colon healthy individuals (male=3, female=3) serving as reference. Our study finds an additional population absorptive secretory epithelial cells within but...
We have previously demonstrated that normal human mammary epithelial cells (MECs) are efficiently immortalized by papillomavirus type 16 (HPV16) E6. HPV16 E6 binds to and induces p53 degradation in vitro a marked reduction of protein MECs. Low-risk HPV6 is defective for binding but MECs at low efficiency. The E6-immortalized had markedly reduced levels p53. To directly investigate whether the ability stimulate required E6-induced immortalization, series mutants were analyzed bind degrade...
Summary Crohn's disease (CD) is characterized by inflammation and an aetiology that still unknown. Hypertrophy of mesenteric fat a reflection activity, as this covers the entire length affected area. Adipocytes synthesize leptin adiponectin, adipocytokines responsible for pro- anti-inflammatory effects. Therefore, we evaluated serum levels adiponectin leptin, well mesenteral expression in active CD those remission. Sixteen patients with ileocaecal followed at Outpatient Clinic,...