A5026678547- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Celiac Disease Research and Management
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Intestinal Malrotation and Obstruction Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Consumer Attitudes and Food Labeling
- Pregnancy and Medication Impact
- Child Nutrition and Feeding Issues
- Renal Diseases and Glomerulopathies
- Colorectal Cancer Surgical Treatments
- Biomedical Research and Pathophysiology
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- COVID-19 Impact on Reproduction
University of Chicago
2020-2024
Lurie Children's Hospital
2021-2024
Northwestern University
2024
Comer Children's Hospital
2020-2022
University of Chicago Medical Center
2018-2021
Klinikum Bremen-Mitte
2009
Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest the gut microbiome. However, establishing reproducible insights into determinants succession has been formidable challenge.
Abstract INTRODUCTION The Crohn’s Disease Exclusion Diet (CDED) is a recently developed dietary therapy for patients with (CD). CDED entails 3-phase, exclusion of potential triggers, allowing select menu safe food options which bolstered by partial enteral nutrition (PEN). Preliminary data has shown that the can be effective in inducing and maintaining remission CD, however, there limited real-world experience, particularly North America. METHODS We conducted retrospective chart review to...
Abstract Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest the gut microbiome. However, establishing reproducible insights into determinants succession has been formidable challenge. Here we use fecal microbiota transplantation (FMT) an natura experimental model to investigate association between metabolic independence resilience stressed environments. Our genome-resolved metagenomics survey suggests that FMT serves...
Despite significant differences in surgical outcomes between pediatric and adult patients with ulcerative colitis (UC) undergoing colectomy, counseling on has largely been guided by data from adults. We compared pouch survival who underwent total proctocolectomy ileal pouch-anal anastomosis (IPAA).
Abstract Background Patients with inflammatory bowel disease (IBD) who undergo proctocolectomy ileal pouch–anal anastomosis may develop pouchitis. We previously proposed a novel endoscopic classification of pouchitis describing 7 phenotypes differing outcomes. This study assessed phenotype transitions over time. Methods classified pouch findings into main phenotypes: (1) normal, (2) afferent limb (AL) involvement, (3) inlet (IL) (4) diffuse, (5) focal inflammation the body, (6) cuffitis, and...
Upadacitinib, an oral Janus kinase inhibitor (JAKi), is approved for inflammatory bowel disease (IBD) in adults. As on-label use will face significant delay pediatrics, a real-world understanding of safety and efficacy children critical.
Abstract Background The modified pouchitis disease activity index (mPDAI) based on clinical symptoms and endoscopic findings is used to diagnose pouchitis, but validated instruments monitor are still lacking. We recently established an classification that described 7 phenotypes with different outcomes. assessed compared mPDAIs among in inflammatory bowel (IBD). Methods retrospectively reviewed pouchoscopies classified them into main phenotypes: normal (n = 25), afferent limb (AL) involvement...
Exclusive enteral nutrition [EEN] is a dietary intervention to induce clinical remission in children with active luminal Crohn's disease [CD]. While changes the gut microbial communities have been implicated achieving this remission, precise understanding of role ecology restoration homeostasis lacking.Here we reconstructed genomes from metagenomes 12 paediatric subjects who were sampled before, during and after EEN. We then classified each population into distinct 'phenotypes' or patterns...
ABSTRACT An expanding gluten‐free marketplace has left children with celiac disease and their families a host of new dietary options. The quality these foods is inconsistent processed items may be high in caloric content while lacking nutritional value. Assessing the preferences cohort via cross‐sectional survey, we find that food have become staple diet, many cases, are consumed to exclusion healthy alternatives. Furthermore, less interested education over time, indicating greatest...
Abstract Background The Mediterranean diet (MD) is recommended for all patients with inflammatory bowel disease (IBD) unless there a specific contraindication. Culinary medicine has emerged as method improving dietary education. Patients and caregivers are often invested in making changes to improve control. Here, we examine the preferences of group young people IBD apply culinary techniques an in-person MD-focused cooking class. Methods A survey evaluating attitudes was sent email listserv...
Refeeding syndrome is diagnosed based on the onset of multiple laboratory abnormalities (most commonly hypophosphatemia) and clinical signs in setting nutrition rehabilitation malnourished patients. Because definitions are not uniform, a broad differential diagnosis should always include renal tubular dysfunction. Our report details 3 year-old child with undiagnosed dysfunction who presented picture refeeding refractory electrolyte abnormalities. A Fanconi was made after urinalysis that...
INTRODUCTION: Proctocolectomy and ileal pouch anal anastomosis (IPAA) is the treatment of choice for patients with medically resistant ulcerative colitis. In this retrospective cohort study, we aimed to observe trends in pre-operative characteristics post-operative outcomes experienced by undergoing IPAA based on decade surgery. METHODS: We obtained electronic medical record data from at our tertiary Inflammatory Bowel Disease Center. Patients a diagnosis UC who underwent an procedure...
Abstract Background Pouchitis can develop in up to 70% of patients with inflammatory bowel disease (IBD) treated by proctocolectomy ileal pouch-anal anastomosis (IPAA). In our recent work, we proposed the “Chicago classification pouchitis” describing 7 main pouch phenotypes differing outcomes. this study, assessed transition classification. Methods This is a retrospective study IBD IPAA who subsequently underwent pouchoscopies at University Chicago between June 1997 and December 2019. We...