A5009494034- Gut microbiota and health
- Diet and metabolism studies
- Oral microbiology and periodontitis research
- Clostridium difficile and Clostridium perfringens research
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Insect symbiosis and bacterial influences
- Metabolomics and Mass Spectrometry Studies
- Probiotics and Fermented Foods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Helicobacter pylori-related gastroenterology studies
- 3D Printing in Biomedical Research
- Genomics and Phylogenetic Studies
- Gastrointestinal motility and disorders
- Seaweed-derived Bioactive Compounds
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Coastal wetland ecosystem dynamics
- Marine and coastal plant biology
- Immune Cell Function and Interaction
- Nosocomial Infections in ICU
- Inflammatory Bowel Disease
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
Vedantra Pharmaceuticals (United States)
2022-2025
University of Chicago
2019-2024
Abstract Introduction Microbial residents of the human oral cavity have long been a major focus microbiology due to their influence on host health and intriguing patterns site specificity amidst lack dispersal limitation. However, determinants niche partitioning in this habitat are yet be fully understood, especially among taxa that belong recently discovered branches microbial life. Results Here, we assemble metagenomes from tongue dental plaque samples multiple individuals reconstruct 790...
Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest the gut microbiome. However, establishing reproducible insights into determinants succession has been formidable challenge.
Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampling of environmental microbes due to ecological evolutionary factors. New strategies needed for ample representation rare taxa slow-growers that often outcompeted by fast-growers experiments. Here we describe a microfluidic platform anaerobically isolates cultivates microbial cells millions picoliter droplets automatically sorts them based on colony density enhance slow-growing...
IgA is prominently secreted at mucosal surfaces and coats a fraction of the commensal microbiota, process that critical for intestinal homeostasis. However, mechanisms induction molecular targets these antibodies remain poorly understood, particularly in humans. Here, we demonstrate microbiota from subset human individuals encode two protein "superantigens" expressed on surface bacteria family Lachnospiraceae such as Ruminococcus gnavus bind variable regions stimulate potent responses mice....
Eukaryotic organisms evolved in a microbial world and often have intimate associations with diverse bacterial groups. Kelp, brown macroalgae the order
Abstract Wolbachia is a genus of obligate intracellular bacteria found in nematodes and arthropods worldwide, including insect vectors that transmit dengue, West Nile, Zika viruses. ’s unique ability to alter host reproductive behavior through its temperate bacteriophage WO has enabled the development new vector control strategies. However, our understanding mobilome beyond bacteriophages incomplete. Here, we reconstruct near-complete genomes from individual ovary metagenomes four wild Culex...
A wide variety of human diseases are associated with loss microbial diversity in the gut, inspiring a great interest diagnostic or therapeutic potential microbiota. However, ecological forces that drive reduction disease states remain unclear, rendering it difficult to ascertain role microbiota emergence severity. One hypothesis explain this phenomenon is diminished as select for populations more fit survive environmental stress caused by inflammation other host factors. Here, we tested on...
Abstract Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest the gut microbiome. However, establishing reproducible insights into determinants succession has been formidable challenge. Here we use fecal microbiota transplantation (FMT) an natura experimental model to investigate association between metabolic independence resilience stressed environments. Our genome-resolved metagenomics survey suggests that FMT serves...
A wide variety of human diseases are associated with loss microbial diversity in the gut, inspiring a great interest diagnostic or therapeutic potential microbiota. However, ecological forces that drive reduction disease states remain unclear, rendering it difficult to ascertain role microbiota emergence severity. One hypothesis explain this phenomenon is diminished as select for populations more fit survive environmental stress caused by inflammation other host factors. Here, we tested on...
A wide variety of human diseases are associated with loss microbial diversity in the gut, inspiring a great interest diagnostic or therapeutic potential microbiota. However, ecological forces that drive reduction disease states remain unclear, rendering it difficult to ascertain role microbiota emergence severity. One hypothesis explain this phenomenon is diminished as select for populations more fit survive environmental stress caused by inflammation other host factors. Here, we tested on...
Abstract Microbial residents of the human oral cavity have long been a major focus microbiology due to their influence on host health and intriguing patterns site specificity amidst lack dispersal limitation. Yet, determinants niche partitioning in this habitat are yet be fully understood, especially among taxa that belong recently discovered branches microbial life. Here we assembled metagenomes from daily tongue dental plaque samples multiple individuals reconstructed 790 non-redundant...
Exclusive enteral nutrition [EEN] is a dietary intervention to induce clinical remission in children with active luminal Crohn's disease [CD]. While changes the gut microbial communities have been implicated achieving this remission, precise understanding of role ecology restoration homeostasis lacking.Here we reconstructed genomes from metagenomes 12 paediatric subjects who were sampled before, during and after EEN. We then classified each population into distinct 'phenotypes' or patterns...
Abstract Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and often yield biased sampling of taxa due to ecological evolutionary factors. New strategies needed enable ample representation rare slow-growers that outcompeted by fast-growing organisms. We developed a microfluidic platform anaerobically isolates cultivates microbial cells millions picoliter droplets automatically sorts based on colony density. applied our strategy mouse human gut...
In 2016, the US Food and Drug Administration published guidance for early development of live biotherapeutic products (LBPs). Of particular importance is characterization LBP strains potential transfer antimicrobial resistance (AMR) genes to relevant microbial organisms in recipients microbiota. Van der Lelie et al, make unsupported claims that strain VE202-06 encodes a transferable vancomycin element. Here we provide our analysis AMR by VE202-06. These data indicate has no risk transferring...
A wide variety of human diseases are associated with loss microbial diversity in the gut, inspiring a great interest diagnostic or therapeutic potential microbiota. However, ecological forces that drive reduction disease states remain unclear, rendering it difficult to ascertain role microbiota emergence severity. One hypothesis explain this phenomenon is diminished as select for populations more fit survive environmental stress caused by inflammation other host factors. Here, we tested on...