A5090724885- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
- Reproductive System and Pregnancy
- Biosimilars and Bioanalytical Methods
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
Rabin Medical Center
2008-2025
Tel Aviv University
2005-2025
University of Chicago
2018-2024
Massanutten Regional Library
2016
Patients with inflammatory bowel diseases (IBD), specifically those treated anti-tumor necrosis factor (TNF)α biologics, are at high risk for vaccine-preventable infections. Their ability to mount adequate vaccine responses is unclear. The aim of the study was assess serologic messenger RNA-Coronavirus Disease 2019 vaccine, and safety profile, in patients IBD stratified according therapy, compared healthy controls (HCs).Prospective, controlled, multicenter Israeli study. Subjects enrolled...
Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and compare anti-tumour necrosis factor [anti-TNF] therapy vedolizumab [VDZ] ustekinumab [UST] real-world setting. A retrospective multicentre study CD-adults curative ICR on was undertaken. ePOR defined as Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD 6. Multivariable logistic regression...
There is a well-established association between inhalational exposure to silica and autoimmune disease. We recently observed an outbreak of silica-related disease among synthetic stone construction workers with silicosis referred for lung transplantation assessment.To characterize the rheumatologic complications in within these highly exposed, clinically well-characterized patients.We systematically reviewed data from all cases due dust our pulmonary institute transplant assessment, which...
Summary Background Following induction therapy with a calcineurin inhibitor (CNI) in severe ulcerative colitis, transitioning to vedolizumab as maintenance could be an option. Aim To report on the largest cohort of patients successfully induced CNIs who were transitioned therapy. Methods This is retrospective observational study adult steroid‐refractory colitis. Patients included if they CNI followed by between January 2014 and December 2018. The primary endpoint was colectomy‐free survival....
Post-transplant diabetes mellitus (PTDM) is a common and potentially serious complication after solid organ transplantation. There are only few data, however, about the incidence of DM in patients undergoing lung transplantation.The medical records 119 consecutive who underwent transplantation from 1998 to September 2004 were reviewed. Patients divided three groups according their status, including pre-transplant DM, PTDM group those without DM. Patient all laboratory data reviewed clinical...
Recurrence of Crohn's disease after surgical resection and primary anastomosis is an important clinical challenge. Previous studies have demonstrated the benefit imidazole antibiotics, but been limited by adverse events medication intolerance. We evaluated whether administration low-dose metronidazole [250 mg three times per day] for 3 months reduces endoscopic postoperative recurrence rates.
It is still of debate whether the advent biologics has been associated with a change in natural history ulcerative colitis [UC]. In this nationwide study we evaluated trends long-term outcomes all patients diagnosed UC Israel during biologic era.Data epi-IIRN cohort were retrieved from four Israeli Health Maintenance Organizations covering 98% population, and linked to Ministry prospective registry on surgeries hospitalizations. Joinpoint Regression Kaplan-Meier survival analyses used,...
Women with inflammatory bowel diseases (IBD) often receive biologics to maintain remission during pregnancy.To assess maternal and neonatal outcomes in patients IBD treated ustekinumab (UST) pregnancy METHODS: In a multicentre, prospective cohort study, we recruited women UST between 2019 2021. Outcomes were compared among UST, anti-tumour necrosis factor α, (anti-TNF) non-UST, non-anti-TNF therapies. UST-treated matched 1:2 controls according age, body mass index parity. Newborns followed...
Abstract Background Acute severe ulcerative colitis (ASUC) is a potentially life-threatening condition. Intravenous corticosteroids are recommended as the initial treatment for adult patients with ASUC. However, one-third of ASUC steroid-refractory and will require medical salvage therapy or surgery. Timely identification who not adequately respond to steroid crucial. This study aimed evaluate whether intestinal ultrasound (IUS), could be additional value in predicting inadequate response IV...
Abstract Background Monitoring inflammatory bowel disease (IBD) activity during pregnancy remains a challenge due to limitations of non-invasive markers. Although fecal calprotectin is considered reliable marker, its utility constrained by limited patient adherence and accessibility. Blood-based markers provide more convenient alternative, however, standard like CRP ESR have reduced reliability in pregnant IBD patients. Serum chitinase-3-like-1 (CHI3L1) promising candidate biomarker...
Abstract Background Patient-reported outcome measures (PROMs) in inflammatory bowel disease (IBD), such as the Short IBD Questionnaire (SIBDQ)1, assess impact on patients' quality of life (QoL). We aimed to validate SIBDQ patients with ulcerative colitis (UC) who underwent ileal pouch-anal anastomosis (IPAA) surgery and correlate activity QoL. Methods This prospective, observational study recruited UC post-IPAA attending a comprehensive pouch clinic at tertiary referral center (Rabin Medical...
Abstract Background Dietary interventions are increasingly used in managing inflammatory bowel diseases (IBD). Effectiveness often depends on patient adherence. We aimed to assess the nutritional and clinical feasibility of a Mediterranean diet (MED) based education program (IBDMED) patients with ulcerative colitis (UC) after pouch surgery. Methods Patients who underwent surgery due were clinically inactive randomly assigned either (A) Intervention group – IBDMED including MED dietary...
Abstract Background Acute severe ulcerative colitis (ASUC) is a life-threatening complication that requires prompt and effective treatment. Disease severity, treatment approaches, outcomes may differ between elderly patients (aged ≥60 years) younger patients. This study aims to compare these factors in cohort of hospitalized ASUC Methods A retrospective was conducted including all admitted 1/2018-12/2023, with who failed oral steroid therapy Rabin Medical Center Israel, large tertiary...
Abstract Background Reduced bone mineral density (BMD), osteoporosis and osteopenia, are prevalent comorbidities in IBD. BMD first line treatment is calcium vitamin D supplementation. Mediterranean diet (MED) pattern has been associated with lower risk of reduced the general population. We aimed to assess effectiveness MED supplementation versus standard care on turn-over metabolites patients quiescent IBD diagnosed BMD. Methods Patients clinical remission, age 20-50 years defined as DXA...
Abstract Background Crohn’s disease (CD) is a heterogeneous condition that can affect the entire gastrointestinal tract, with isolated small bowel (SB) involvement occurring in 20–30% of patients. According to ECCO and other international guidelines, standard diagnostic approach for CD includes ileocolonoscopy cross-sectional SB imaging. When these modalities yield inconclusive results, video capsule endoscopy (VCE) recommended evaluating mucosa. Despite negative findings on comprehensive...
Abstract Background Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment in patients refractory/complicated ulcerative colitis (UC). Inflammation of small rectal remnant below IPAA lines (“cuff”) designated cuffitis. Despite its clinical significance and characteristic endoscopic histologic features, risk factors are vague. This study aimed to decipher demographic, disease, surgery-related for histologically proven Methods In a comprehensive pouch...
Abstract Background Crohn’s disease (CD) is a heterogeneous condition with potentially complicated course. We aimed to evaluate the rates of course within real-world prospective inception cohort patients newly diagnosed CD (ndCD). Methods A prospective, observational, longitudinal study involving consecutive adults ndCD was conducted at tertiary referral center. Patients were managed discretion their treating physician. Key outcomes defined as ‘complicated course’ (any CD-related...
Abstract Background Patients with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA) may develop inflammation of the pouch (pouchitis), rectal cuff (cuffitis), or both. We aimed to evaluate how isolated cuffitis impacts patients' quality life (QoL). Methods In a comprehensive clinic at tertiary referral center (Rabin Medical Center), consenting patients were followed prospectively, routine clinical, laboratory, endoscopic, and QoL evaluations. IPAA due UC having ≥1 biopsy...
Abstract Background Pouch disorders are common and may present with symptoms of increased stool frequency, urgency, incontinence, pelvic cramping, perianal drainage, leading to poor sleep, fatigue, disability. This topical review provides expert consensus recommendations for the diagnosis management most inflammatory, functional, structural neoplastic pouch disorders. Methods An open-call participation was made all ECCO members. Four working groups were formed each focusing on a specific...