A5004315487- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders
- Gastroesophageal reflux and treatments
- IgG4-Related and Inflammatory Diseases
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Celiac Disease Research and Management
- Gastric Cancer Management and Outcomes
- Biosimilars and Bioanalytical Methods
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Digestive system and related health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Angiogenesis and VEGF in Cancer
- Pharmacological Receptor Mechanisms and Effects
- Biosensors and Analytical Detection
- Occupational and environmental lung diseases
Rabin Medical Center
2013-2025
Tel Aviv University
2018-2025
Clalit Health Services
2023
NeoGenomics (United States)
2007
Multiple Sclerosis Center of Atlanta
2007
Soroka Medical Center
1995
Ben-Gurion University of the Negev
1995
Patients with inflammatory bowel diseases (IBD), specifically those treated anti-tumor necrosis factor (TNF)α biologics, are at high risk for vaccine-preventable infections. Their ability to mount adequate vaccine responses is unclear. The aim of the study was assess serologic messenger RNA-Coronavirus Disease 2019 vaccine, and safety profile, in patients IBD stratified according therapy, compared healthy controls (HCs).Prospective, controlled, multicenter Israeli study. Subjects enrolled...
Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and compare anti-tumour necrosis factor [anti-TNF] therapy vedolizumab [VDZ] ustekinumab [UST] real-world setting. A retrospective multicentre study CD-adults curative ICR on was undertaken. ePOR defined as Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD 6. Multivariable logistic regression...
Abstract Background Acute severe ulcerative colitis (ASUC) is a potentially life-threatening condition. Intravenous corticosteroids are recommended as the initial treatment for adult patients with ASUC. However, one-third of ASUC steroid-refractory and will require medical salvage therapy or surgery. Timely identification who not adequately respond to steroid crucial. This study aimed evaluate whether intestinal ultrasound (IUS), could be additional value in predicting inadequate response IV...
Abstract Background Reduced bone mineral density (BMD), osteoporosis and osteopenia, are prevalent comorbidities in IBD. BMD first line treatment is calcium vitamin D supplementation. Mediterranean diet (MED) pattern has been associated with lower risk of reduced the general population. We aimed to assess effectiveness MED supplementation versus standard care on turn-over metabolites patients quiescent IBD diagnosed BMD. Methods Patients clinical remission, age 20-50 years defined as DXA...
Abstract Background Patients with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA) may develop inflammation of the pouch (pouchitis), rectal cuff (cuffitis), or both. We aimed to evaluate how isolated cuffitis impacts patients' quality life (QoL). Methods In a comprehensive clinic at tertiary referral center (Rabin Medical Center), consenting patients were followed prospectively, routine clinical, laboratory, endoscopic, and QoL evaluations. IPAA due UC having ≥1 biopsy...
Primary sclerosing cholangitis (PSC) is a rare chronic progressive cholestatic disorder. We assessed its characteristics and natural history in Israel compared outcome with respect to coexisting inflammatory bowel disease (IBD).Data on characteristics, course were retrospectively retrieved patients diagnosed PSC from five large Israeli medical centers between 1988 2012. Patients isolated those IBD identify predictors of outcome.Of 141 (56% males) confirmed PSC, 98 (69.5%) had IBD. The...
Abstract Background Autoimmune pancreatitis [AIP] is rarely associated with inflammatory bowel disease [IBD]. The long-term outcomes of AIP and IBD in patients coexisting AIP–IBD predictors complicated course have been reported. Methods An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases diagnosed IBD. Complicated was defined as a composite endocrine and/or exocrine pancreatic insufficiency, cancer. We explored factors Results included 96...
Introduction Real-world data on tofacitinib's effectiveness is limited and mainly retrospective or registry-based. We elected to conduct a pragmatic prospective study assess the efficacy of tofacitinib for moderate severe ulcerative colitis (UC), aiming evaluate ability intestinal ultrasound (IUS) discriminate responders vs. non-responders in real-time.
Multiple sclerosis (MS) is a demyelinating disease characterized by an unpredictable clinical course with intermittent relapses that lead over time to significant neurological disability. Clinical and radiological variables are limited in the ability predict course. Peripheral blood genome scale analyses were used characterize MS patients different types, but not for prediction of outcome. Using complementary-DNA microarrays we studied peripheral-blood gene expression patterns 53...
Background Threshold values for 13 C‐urea breath test (13C‐ UBT ) positivity may be affected by various sociodemographic, host, bacterial, and laboratory factors. Manufacturer recommended cutoffs 13C‐ assays not applicable in all settings. Optimizing have profound public health ramifications. We aimed to determine the optimal threshold our population. Methods Consecutive samples collected at central from patients undergoing a first‐time between 1 January 2010 31 December 2015 were included....
Patients with inflammatory bowel disease (IBD) treated anti-tumor-necrosis factor-alpha (TNFα) exhibited lower serologic responses one-month following the second dose of COVID-19 BNT162b2 vaccine compared to those not anti-TNFα (non-anti-TNFα) or healthy controls (HCs). We comprehensively analyzed long-term humoral responses, including anti-spike (S) antibodies, serum inhibition, neutralization, cross-reactivity and circulating B cell six months post BNT162b2, in patients IBD stratified by...
Patients with ulcerative colitis (UC) undergoing proctocolectomy and ileal pouch-anal anastomosis (IPAA) may eventually require biologic therapy. Factors associated therapy after IPAA have not been previously studied.
Abstract Background Real-world data on outcomes of patients with newly diagnosed Crohn’s disease (ndCD) is limited. We aimed to assess the achievement corticosteroid-free clinical remission (CS-free CR) and other therapeutic targets 1 year after diagnosis in a cohort ndCD treated by multidisciplinary team (MDT). Methods A prospective observational study was conducted consecutive treatment-naïve adults ndCD. Patients received management at treating physician’s discretion, along tailored...
Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity patients with a J-pouch is unknown.Patients acute pouchitis were prospectively treated 2-week course antibiotics. The full Pouchitis Disease Activity Index, FC, QoL measured at baseline after antibiotic therapy.Twenty enrolled. After 2 weeks treatment, the Index decreased from median 9 to 5 ( P = 0.007). FC 661 ug/g 294 0.02), improved significantly.FC real-time changes inflammatory...
Background and Aim: Drug sustainability (DS) is a surrogate marker for treatment efficacy. We aimed to compare the DS of two main biologics used treat moderate-to-severe ulcerative colitis (UC), infliximab (IFX) vedolizumab (VDZ), in real-world setting. Methods: conducted retrospective cohort study at tertiary medical center Israel. included patients treated between 1 December 2017 May 2021, who were followed up 300 weeks. was defined as corticosteroid-, surgical-, hospitalization-free...
Although the efficacy of first-line treatment for Helicobacter pylori infection should aim to be > 90%, it is unclear whether this target has been achieved in Israel. We aimed determine success rate H. and describe temporal changes our region. Methods: Adult patients who underwent a first-time -C13-urea breath test (C13-UBT) at Clalit Health Services between January 1, 2010 December 31, 2015 were included. In order isolate naïve "test-and-treat" population unlikely have undergone an initial...
Gastric intestinal metaplasia is a pre-cancerous condition associated with multiple factors.We evaluated whether cumulative proton pump inhibitor dose the diagnosis of gastric while controlling for variables.We retrospectively identified patients who underwent upper endoscopy biopsy between 2005 and 2014. Covariate data retrieved included age, sex, ethnicity, smoking status, Helicobacter pylori status (based on clarithromycin-amoxicillin-proton issued), issued within 10 years (quartiles...
The aim was to assess proactive specialized inflammatory bowel diseases (IBD) emergency department (ED) consultation and multidisciplinary IBD team (IBD-MDT) intervention on IBD-related patient outcomes after discharge.Despite advances in care, ED visits have increased substantially contribute the burden.Consecutive patients with (below 50 y) who visited during November 2017 April 2018 (intervention group) were compared that same 2014 (standard-care group). primary hospitalization revisits...
Skin eruptions are prevalent among patients with inflammatory bowel diseases (IBD), often associated therapies and frequently leading to dermatological consults treatment interruptions. We aimed assess the impact of joint shared decision-making in a multidisciplinary (MDT) IBD-DERMA clinic.This retrospective cohort study assessed consecutive group IBD who were referred for consultation an MDT clinic at tertiary referral center Israel.Over 1 year, 118 evaluated MDT-IBD-DERMA clinic: 68...