A5019602506- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Biosimilars and Bioanalytical Methods
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Tuberculosis Research and Epidemiology
- Brain Tumor Detection and Classification
- Gut microbiota and health
- Functional Brain Connectivity Studies
- Clinical Nutrition and Gastroenterology
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Digestive system and related health
- IgG4-Related and Inflammatory Diseases
- Optical Imaging and Spectroscopy Techniques
- Pregnancy and Medication Impact
- Asthma and respiratory diseases
Aalborg University Hospital
2016-2025
Aalborg University
2013-2025
Predict (France)
2025
Faculty (United Kingdom)
2016
Aarhus University
1999-2013
Svendborg Sygehus
2011-2013
Aarhus University Hospital
1999-2001
ABSTRACT Background Up to 30% of patients with Crohn's disease (CD) will experience a mild course. However, there is no consensus definition for CD. Aim To examine the Simple Endoscopic Score (SES‐CD) thresholds best associated low likelihood long‐term progression. Methods We conducted multicentre retrospective cohort study at three tertiary care centres in United States and Europe. analysed data from 177 surgery‐naïve CD who had endoscopic assessment while not on immunosuppressive therapy....
As no population-based study has investigated the susceptibility and disease course of COVID-19 among patients with inflammatory bowel diseases [IBD], we aimed to investigate this topic in a setting.Two cohorts were investigated. First, nationwide cohort all IBD diagnosed was prospectively followed courses both diseases. Second, within 2.6 million Danish citizens, identified individuals tested for SARS-CoV-2 determine occurrence without other immune-mediated [IMIDs].Between January 28, 2020...
The Danish National Patient Registry (DNPR) is recognized for providing high-quality data. However, only a few minor studies have validated inflammatory bowel disease (IBD) diagnoses in the DNPR, reporting various degrees of validity. To pave way large-scale IBD Denmark, we aimed to investigate validity among >8000 patients registered DNPR between 2002 and 2020 North Denmark Region.To evaluate reliability initially compared all with one diagnosis during 2002-2020 list already verified...
While the incidence of inflammatory bowel disease (IBD) is rising globally, it has been suggested to stabilize in westernized countries, but this not yet shown exhaustive and large cohorts. We generated an IBD cohort North Denmark (NorDIBD) 6,158 patients with diagnosed from 1978 2020, based on all recorded verified diagnoses region. describing establishment cohort, we aimed present accurate prevalence over 4 decades.The NorDIBD covered pediatric adult diagnosis dated between January 1,...
Summary Background Anti‐tumor necrosis factor‐α ( TNF ‐α) is used for the treatment of severe cases IBD , including Crohn's disease CD ) and ulcerative colitis UC ). However, one‐third patients do not respond to treatment. We have previously investigated whether single nucleotide polymorphisms SNP s) in genes involved inflammation were associated with response anti‐ therapy among or . Aim A new cohort was established replication previous findings identify s response. Methods Fifty‐three...
Abstract Background and Aims Inflammatory bowel disease (IBD) is associated with manifestations in organs other than the gastrointestinal tract. In this study, we aimed to estimate odds of obstructive lung (OLD) before IBD onset risk OLD after onset. Methods a nationwide population‐based Danish cohort study from 1999 2018, individuals were identified using registries. Between 2003 2013, 24,238 matched 1:10 non‐IBD individuals. Logistic regression was used prevalence ratio for Time‐to‐event...
Retrospective studies suggest that for patients with ulcerative colitis (UC) combination therapy low-dose azathioprine and allopurinol (L-AZA/ALLO) may result in higher remission rates than monotherapy (AZA). We prospectively investigated the effects of these drugs moderate-to-severe UC.
Abstract Background Individuals with inflammatory bowel disease (IBD) may experience impaired body image, poorer quality of life, and reduced sexual functioning compared to the general population. However, variations in health across diverse spectrum IBD must be expected. This study examined challenges dysfunctions Danish individuals without IBD. Methods In this population-based cross-sectional study, 62,675 participants from nationally representative Project SEXUS cohort...
Abstract Background The pharmacokinetic (PK) profile of vedolizumab during pregnancy is not fully characterised, though concentrations have been reported to drop1.To minimise transplacental transfer, discontinuation in the 3rd trimester has suggested, but this may lead flare IBD and postpartum2. This study aimed characterise changes PK using mathematical modelling explore dosing scenarios guide decisions on 3rd-trimester dosing. Methods A multicenter, prospective, observational was conducted...
Abstract Background Around 20-30% of patients with Crohn's disease (CD) experience a mild course. However, identifying likely to maintain course is challenging. This study aimed identify molecular features CD by exploring biological datasets from two large patient cohorts. Methods Patients were analysed longitudinal cohorts: the Mount Sinai and Colitis Registry (MSSCR) observational cohort Ocean State Crohn’s (OSCCAR) inception cohort. Baseline assessments in both cohorts included...
Summary Background Little is known about the consequences of intrauterine exposure to, and post‐natal clearance of, vedolizumab. Aims To investigate levels vedolizumab in umbilical cord blood newborns rates after birth, as well how these correlated with maternal drug levels, risk infection developmental milestones during first year life Methods Vedolizumab‐treated pregnant women inflammatory bowel disease were prospectively recruited from 12 hospitals Denmark Canada 2016‐2020. Demographics...
Abstract Background Autoimmune pancreatitis [AIP] is rarely associated with inflammatory bowel disease [IBD]. The long-term outcomes of AIP and IBD in patients coexisting AIP–IBD predictors complicated course have been reported. Methods An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases diagnosed IBD. Complicated was defined as a composite endocrine and/or exocrine pancreatic insufficiency, cancer. We explored factors Results included 96...
Introduction A large proportion of patients with inflammatory bowel disease (IBD) experience IBD-related conditions outside the gastrointestinal tract, termed extraintestinal manifestations (EIMs) which further decreases quality life and, in extreme cases, can be threatening. The pathogenesis EIMs remains unknown, and although gut microbiota alterations are a well-known characteristic IBD, its relationship sparsely investigated. This study aimed to compare IBD without EIMs.
The Danish Neuro Oncology Group (DNOG) has established national consensus guidelines for the delineation of organs at risk (OAR) structures based on published literature. This study was conducted to finalise these and evaluate inter-observer variability delineated OAR by expert observers.The DNOG were formed participants from all centres that treat brain tumours with radiotherapy. In a two-day workshop, discussed finalised pilot study. Following this, ten contoured following OARs T1-weighted...
This Danish nationwide genome-wide association study aims to identify biomarkers of severe vs less ulcerative colitis.
The health consequences of coronavirus disease 2019 [COVID-19] among patients with ulcerative colitis [UC] and Crohn's [CD] remain largely unknown. We aimed to investigate the outcomes long-term effects COVID-19 in UC or CD.We conducted a prospective, population-based study covering all Danish CD confirmed between January 28, 2020 April 1, 2021, through medical records questionnaires.All 319 197 who developed Denmark were included this compared background population [N = 230 087]. A...
Objective: We have introduced online touch screens in the waiting room for patients with ulcerative colitis (UC) or Crohn's disease (CD) recording of symptoms before their consultation. This has made activity scores readily available to physician our newly established database, 'Gastrobio'. wanted validate use compared paper questionnaires.Material and methods: A total 54 UC 74 CD were included study. The filled out Short Health Scale (SHS) Simple Clinical Colitis Activity Index (SSCAI). SHS...
Long-term data on real life use of infliximab (IFX) for inflammatory bowel disease (IBD) are lacking. We studied prescription patterns during the first 16 years following marketing authorization. In a population-based cohort from North Denmark Region, all IBD patients exposed to IFX 1999 2014 were identified. A total 623 (210 with ulcerative colitis [UC] and 413 Crohn's [CD]) IFX. UC, age at exposure decreased by 10 months per calendar year (P < 0.05) study period. CD, duration time 7...
Inflammatory bowel diseases (IBDs) are chronic of unknown cause characterised by a progressive and unpredictable disease course. In the last decade, biological treatment has become cornerstone in IBD. However, one-in-three-to-four patients do not respond to first-line agents another third see their response diminish over time. This highlights an unmet need for optimising use biologicals prediction response. Considering multifaceted nature IBD, we hypothesise that multiomics profiling...