A5081967975- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Delphi Technique in Research
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemodynamic Monitoring and Therapy
- Thermography and Photoacoustic Techniques
- Respiratory and Cough-Related Research
- Photoacoustic and Ultrasonic Imaging
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Tuberculosis Research and Epidemiology
- Health disparities and outcomes
- Cardiac Arrest and Resuscitation
- Palliative Care and End-of-Life Issues
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Renal function and acid-base balance
Aalborg University Hospital
2016-2025
Aalborg University
2015-2025
Gentofte Hospital
2023
Institut für Lungenforschung
2018-2021
North Denmark Region
2020
Faculty (United Kingdom)
2014-2015
Aarhus University
2008-2012
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2004-2006
Regionshospital Nordjylland
2005
Klinik für Frauenheilkunde
1987-2004
Background: This study investigated the long-term effects of humidified high-flow nasal cannula (HFNC) in COPD patients with chronic hypoxemic respiratory failure treated oxygen therapy (LTOT). Patients and methods: A total 200 were randomized into usual care ± HFNC. At inclusion, acute exacerbation (AECOPD) hospital admissions 1 year before modified Medical Research Council (mMRC) score, St George's Respiratory Questionnaire (SGRQ), forced expiratory volume second (FEV ), 6-minute walk test...
The role of Pseudomonas aeruginosa in the long-term prognosis chronic obstructive pulmonary disease (COPD) is unknown. purpose this study was to determine whether P. associated with increased risk exacerbations or death patients COPD.This a multiregional epidemiological based on complete data COPD outpatients between 1 January 2010 and 31 October 2017 corresponding microbiology national register data. Time-dependent Cox proportional hazards models propensity matching used estimate...
This study aimed to explore return work after COVID-19 and how disease severity affects this.This is a Nationwide Danish registry-based cohort using retrospective follow-up design.Patients with first-time positive SARS-CoV-2 polymerase chain reaction test between 1 January 2020 30 May 2020, including 18-64 years old, 30-day survivors, available the workforce at time of first were included. Admission types (i.e. no admission, admission non-intensive care unit [ICU] department ICU) was...
Motivation: The immune response to bacterial infection represents a complex network of dynamic gene and protein interactions. We present an optimized reverse engineering strategy aimed at reconstruction this kind interaction networks. proposed approach is based on both microarray data available biological knowledge.
Isavuconazole (ISZ) is used in the treatment of aspergillosis and mucormycosis. The purpose this study was to evaluate therapeutic drug monitoring (TDM) ISZ samples from a clinical setting performed at Statens Serum Institut. Materials/methods: serum concentrations were determined by fluorescent detection on UHPLC. Serum-ISZ (s-ISZ) results included compared those serum-voriconazole (s-VRZ) 33 month period March 2017. Clinical data obtained for patients receiving ISZ. range initially 2–10...
Abstract Background and Aims Inflammatory bowel disease (IBD) is associated with manifestations in organs other than the gastrointestinal tract. In this study, we aimed to estimate odds of obstructive lung (OLD) before IBD onset risk OLD after onset. Methods a nationwide population‐based Danish cohort study from 1999 2018, individuals were identified using registries. Between 2003 2013, 24,238 matched 1:10 non‐IBD individuals. Logistic regression was used prevalence ratio for Time‐to‐event...
Introduction Long-term High Flow Nasal Cannula (LT-HFNC), defined as treatment provided to patients with chronic pulmonary conditions during stable phases, has emerged a home in different categories of lung diseases recent years.Methods This paper summarizes the physiological effects LT-HFNC and evaluates clinical knowledge date about obstructive disease, interstitial disease bronchiectasis. The guideline is translated summarized this presented unabridged an appendix paper.Results describes...
<sec> <title>BACKGROUND</title> Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality, and exercise has been shown to reduce both. Health conditions, environmental factors, logistical challenges are often barriers for participation in pulmonary rehabilitation (PR). Given the many individuals with COPD face when attending healthcare centers PR, virtual home-based cycling could be an option. </sec> <title>OBJECTIVE</title> This study aimed explore development...
Background Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory associated with significant health decline and economic burdens. Pulmonary rehabilitation an effective intervention, but securing adherence to exercise difficult, particularly for frail disabled patients, challenged by leaving their home. Home-based emerging alternative persons COPD, long-term unclear. This study aims investigate the effects, experiences acceptability of home-based cycling patients COPD...
Background Studies indicate a U-shaped relationship between alcohol consumption (AC) and chronic obstructive pulmonary disease (COPD) with low-moderate AC being protective. We investigated the influence of debut (ACD) at different ages on forced expiratory volume in first second (FEV1), vital capacity (FVC) COPD development.
Introduction Non-invasive ventilation (NIV) treatment is effective and potentially lifesaving in patients with respiratory acidosis acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, feelings anxiety during NIV are common, leading to premature patient-initiated termination treatment.The primary aim this study examine whether psychiatric disorders a risk factor treatment. The secondary the patterns use sedative drugs
Abstract: Low concentrations of hemoglobin have previously been demonstrated in many patients with COPD. There is evidence anemia as a prognostic factor acute exacerbations, but the detailed relationship between and mortality not known. A register-based cohort admitted for first time to Danish hospitals exacerbations COPD from 2007 through 2012 was established. Age, sex, comorbidities, medication, renal function, were retrieved. Sex-specific survival analyses fitted different rounded...
Abstract Background No short patient-reported outcome (PRO) instruments assess overall health status across different obstructive lung diseases. Thus, the wording of introduction to Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) was modified permit use in asthma and/or COPD. This tool is called Airways (CAAT). Methods The psychometric properties CAAT were evaluated using baseline data from NOVELTY study (NCT02760329) patients with physician-assigned asthma, + COPD or...
Computed tomography (CT) examinations are increasingly used worldwide and incidental findings growing likewise. Lung cancer stage at diagnosis is pivotal to survival. The earliest of lung cancer, IA in most cases asymptomatic. Potentially, increased use clinical CTs could induce a shift toward earlier diagnosis.Data on the number CT thorax Denmark distribution Danish patients 2013-2020 were acquired from, respectively, Health Data Authority Cancer Registry. Clinical auditing was performed...
Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy rare among women and studies of the prevalence causative role non-occupational exposure with MM are scarce. This observational study aimed to elucidate patterns MM. Methods All histological cytological specimens from diagnosed between 1974–2015 at Institute Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational habitation information obtained Danish registries...
To limit the ongoing COVID-19 pandemic, social distancing was introduced globally in first half of 2020. COPD-patients were identified as a group at special risk connection with SARS-CoV-2 infection. Hence, has been important this patients. However, little is known motives and consequences these vulnerable The aim study to explore perspectives experiences on among during pandemic. Patients qualitative selected strategically, equally allocated between gender age obtain maximum variation. Data...
A method for automatically quantifying emphysema regions using High-Resolution Computed Tomography (HRCT) scans of patients with chronic obstructive pulmonary disease (COPD) that does not require manually annotated training is presented.HRCT controls and COPD diverse severity are acquired at two different centers. Textural features from co-occurrence matrices Gaussian filter banks used to characterize the lung parenchyma in scans. Two robust versions multiple instance learning (MIL)...