Ingrid Louise Titlestad
A5083344850- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Emergency and Acute Care Studies
- Respiratory and Cough-Related Research
- Family and Patient Care in Intensive Care Units
- Pneumothorax, Barotrauma, Emphysema
- Lung Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Immune Cell Function and Interaction
- Chronic Disease Management Strategies
- Enhanced Recovery After Surgery
- T-cell and B-cell Immunology
- Tracheal and airway disorders
- Palliative Care and End-of-Life Issues
- Pediatric health and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Reproductive System and Pregnancy
- Connective tissue disorders research
- Ultrasound in Clinical Applications
- Glycosylation and Glycoproteins Research
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
Odense University Hospital
2015-2024
University of Southern Denmark
2012-2024
Isabela State University
2023
Kongsberg Innovasjon (Norway)
2018
Respiratory Clinical Trials
2014
There is a major need for effective, well-tolerated treatments idiopathic pulmonary fibrosis (IPF).To assess the efficacy and safety of autotaxin inhibitor ziritaxestat in patients with IPF.The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 2, were conducted Africa, Asia-Pacific region, Europe, Latin America, Middle East, North America (26 countries). A total 1306 IPF (525 at 106 sites 781 121 2). Enrollment began November 2018 both trials follow-up was completed...
Summary We investigated the effect of daily real-time teleconsultations for one week between hospital-based nurses specialised in respiratory diseases and patients with severe COPD discharged after acute exacerbation. Patients admitted exacerbation chronic obstructive pulmonary disease (AECOPD) at two hospitals were recruited hospital discharge. They randomly assigned to intervention or control. The telemedicine equipment consisted a briefcase built-in computer including web camera,...
Primary spontaneous pneumothorax frequently recurs after chest tube management. Evidence is lacking whether patients may benefit from surgery following their first episode.We performed a multicentre, randomized trial and enrolled young, otherwise healthy admitted with episode of primary treated using conventional drainage. Patients underwent high-resolution computed tomography on fully expanded lungs, web-based randomization, we assigned to continued conservative treatment or followed by...
Previous smaller case series suggested that cannabis smoking may cause spontaneous pneumothorax, but this finding remains controversial. We investigated the possible association between tobacco and risk of having a primary pneumothorax in large, homogeneous cohort young, healthy individuals.In case-control study, we prospectively young (≤40 years) patients admitted Western Denmark from 2009 to 2016 with their first episode pneumothorax. Baseline characteristics habits including both were...
An essential element in the treatment of patients with chronic obstructive pulmonary disease (COPD) is rehabilitation, which supervised training an important part. However, not all individuals severe COPD can participate rehabilitation provided by hospitals and municipal centres due to distance venues transportation difficulties. The aim study was assess feasibility individualized home-based counselling programme via video conference after hospitalization including assessment safety,...
Implementation of noninvasive ventilation (NIV) as an add-on treatment has been routinely used in a non-intensive care setting since 2004 for patients with chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure at university hospital Denmark. Although randomized controlled trials show lowered mortality rates highly selected exacerbation failure, there are only few reports on long-term survival after receiving NIV. We present all-cause data from NIV the first...
The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy benralizumab for patients with severe eosinophilic asthma. Patients from DB could join 56-week in Practice (IP) single-arm, open-label extension substudy.Assess potential standard-of-care background medication reductions while maintaining asthma control benralizumab.Following completion, eligible adults were enrolled IP. After an 8-week run-in benralizumab,...
Background Recent studies have found vitamin D (25-OHD) deficiency and insufficiency to be common among patients with COPD. Serum level of 25-OHD seems correlate pulmonary function, COPD disease staging, increased susceptibility respiratory infections. We wanted investigate whether or was associated mortality rate in suffering from advanced Methods serum levels were measured 462 moderate very severe Patients stratified into three groups according 25-OHD. Outcome measure a 10 year follow-up...
Abstract Introduction Crowding of the emergency departments is an increasing problem. Many patients with exacerbation chronic obstructive pulmonary disease (COPD) are often treated in for a very short period before discharged to their homes. It possible that this treatment could take place patients’ homes sufficient diagnostics supporting treatment. In effort keep and some these thus reduce patient load at departments, we implemented prehospital treat-and-release strategy based on...
Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 potential biomarker inflammation mortality in patients suffering from disease, but its prognostic value with COPD remains unknown. We investigated whether high plasma was associated increased moderate to very severe COPD. Four hundred ninety-three were followed prospectively for up 10 years. Patients divided into two groups according YKL-40: concentration...
The incidence of primary spontaneous pneumothorax is partly unknown. Commonly quoted estimates were published decades ago and recent large-scale epidemiological publications lack validation. We validated the diagnosis in a national registry estimated young patients.Complete data on patients with an assigned was retrieved from National Danish Patient Registry. Initially, we selected population: all patient charts one cardiothoracic department over 25-year period (1984-2008) reviewed....
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD).To develop novel, induced sputum endpoints to demonstrate changes in neutrophil phenotype lung by administering nemiralisib, a potent and selective inhaled PI3Kδ inhibitor, stable COPD or acute exacerbation (AE) COPD.In two randomized, double-blind, placebo-controlled clinical trials A)...
Variation in surfactant protein D (SP-D) is associated with lung function tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists general population and could be used to identify individuals sensitive damage. The between serum SP-D (sSP-D) expiratory was assessed a cross-sectional design Danish twin (n = 1,512, 18-72 yr old). adjusted heritability estimates for function, associations gene (SFTPD) single-nucleotide polymorphisms or haplotypes, were...
Calprotectin comprises more than 45% of the cytosolic content neutrophil granulocytes. Because pathogenesis, disease activity and progression in COPD are believed to be partly dependent driven inflammation we decided investigate whether plasma level calprotectin (p-calprotectin) was associated with all-cause mortality patients COPD. We measured p-calprotectin blood samples from 460 moderate very severe stable phase. Patients were stratified into three groups according level. Outcome measure...
Introduction The diagnosis of tuberculosis (TB) disease and TB infection (TBI) remains a challenge, there is need for non-invasive blood-based methods to differentiate from conditions mimicking (CMTB), TBI, healthy controls (HC). We aimed determine whether combination cytokines established biomarkers could discriminate between 1) CMTB 2) TBI 3) HC. Methods used hemoglobin, total white blood cell count, neutrophils, monocytes, C-reactive protein, ten Meso Scale Discovery analyzed (interleukin...