A5040253604- Liver Disease Diagnosis and Treatment
- Spaceflight effects on biology
- HIV Research and Treatment
- RNA Research and Splicing
- Space Science and Extraterrestrial Life
- Asthma and respiratory diseases
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Space Exploration and Technology
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Rheumatoid Arthritis Research and Therapies
- Tissue Engineering and Regenerative Medicine
- Neuroethics, Human Enhancement, Biomedical Innovations
- RNA Interference and Gene Delivery
- Respiratory and Cough-Related Research
- Liver Diseases and Immunity
- Cytokine Signaling Pathways and Interactions
- Wound Healing and Treatments
- RNA and protein synthesis mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- HIV/AIDS drug development and treatment
- Sphingolipid Metabolism and Signaling
University of Nottingham
2021
Sherwood Scientific (United Kingdom)
2019-2021
AstraZeneca (United Kingdom)
2010-2020
Royal Astronomical Society
2018
Loughborough University
2004-2017
X-Fab (Germany)
2016
First Affiliated Hospital of Wenzhou Medical University
2015
Wenzhou Medical University
2015
Fudan University Shanghai Cancer Center
2015
AstraZeneca (Poland)
2015
The primary response transcription factor, early growth response-1 (Egr-1), is rapidly activated by a variety of extracellular stimuli. Egr-1 binds to sequence found in the promoters genes involved vascular injury, such as PDGF-A and tissue trans-activates their expression endothelial cells fluid shear stress. Here we show that egr-1 mRNA increased after 30 min flow human aortic cell HeLa cultures. Transient transfection with reporter gene constructs driven murine or 5' flanking revealed...
AZD9056 is a selective orally active inhibitor of the purinergic receptor P2X7, which key player in generation and secretion several proinflammatory cytokines involved pathogenesis Crohn's disease (CD). The aim this phase IIa study was to assess efficacy safety for treatment moderately severely CD. We conducted placebo-controlled, multicenter, double-blind patients with CD as defined by Activity Index (CDAI) at least 220. Patients were randomized 2:1 mode either 200 mg administered tablet...
Abstract Off‐target pharmacology may contribute to both adverse and beneficial effects of a new drug. In vitro pharmacological profiling is often applied early in drug discovery; there are fewer reports addressing the relevance broad profiles clinical effects. Here, we have characterized profile active metabolite fostamatinib, R406, linking an understanding selectivity increase blood pressure observed studies. R406 was profiled range assays generate comprehensive key targets were further...
The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified novel set of cyclic imide compounds that inhibited receptor-mediated dye uptake human macrophage THP-1 cells. In this study the actions and selectivity one these compounds, AZ11645373, were characterized.We measured membrane currents, calcium influx, YOPRO-1 from HEK cells expressing individual P2X...
The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under clinical trials for rheumatoid arthritis. Anti-inflammatory actions of P2X(7)R are considered to result from inhibition P2X(7)R-induced release proinflammatory cytokines activated macrophages. However, P2X(7)Rs also expressed resting macrophages, suggesting that may signal via cytokine-independent mechanisms involved joint disease. In...
// Jie You 1, 2, * , Gui-Qi Zhu 3, 4, Linka Xie 5, Wen-Yue Liu 6 Liang Shi 7 Ou-Chen Wang 1 Zong-Hai Huang 2 Martin Braddock 8 Gui-Long Guo Ming-Hua Zheng 9 Department of Oncological Surgery, The First Affiliated Hospital Wenzhou Medical University, 325000, China General Zhujiang Hospital, Southern Guangzhou 510282, 3 Infection and Liver Diseases, Research Center, 4 School Clinical Sciences, 5 Cancer Center Union Tongji College, Huazhong University Science Technology, Wuhan 430022,...
Abstract The development and deployment of artificial intelligence (AI) is will profoundly reshape human society, the culture composition civilisations which make up kind. All technological triggers tend to drive a hype curve over time realised by an output often unexpected, taking both pessimistic optimistic perspectives actions drivers, contributors enablers on journey where ultimate destination may be unclear. In this paper we hypothesise that not dissimilar personal described Kubler-Ross...
Objectives The relationship between normal low-density lipoprotein cholesterol (LDL-c) levels and non-alcoholic fatty liver disease (NAFLD) in non-obese individuals remains unclear. We aimed to investigate the precise prevalence incidence of NAFLD within LDL-c range individuals. Design Cross-sectional longitudinal study. Setting Wenzhou Medical Center People's Hospital from 2010 2014. Participants 183 903 were enrolled a cross-sectional population, total 16 173 initially NAFLD-free included...
The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at promoter level and utilizes overlapping signal transduction cascades activate expression of genes involved in many biological processes.
The aim of this study was to examine the association between sex-specific serum uric acid (sUA) levels and NAFLD in a large population-based study. A total 60,455 subjects from 2 separate medical centers were included. Sex-specific sUA quartiles (Q1–Q4) defined: ≤330, 331–380, 381–435, ≥436 μmol/L for male; ≤230, 231–270, 271–310, ≥311 female. odds ratios (ORs), hazard (HRs), 95% confidence intervals (CIs) calculated across each quartile sUA, using Q1 as reference. After adjusting known...
While humans have made enormous progress in the exploration and exploitation of Earth, outer space remains beyond current human capabilities. The principal challenges lie technology engineering which includes protection astronauts from hazards working living environment. These may lead to a paradoxical situation where ability ensure acceptable risk/benefit for becomes dissociated rate scientific discovery declines. In this paper, we discuss predominant environment health argue that...
Future human space missions to Mars and beyond may be realized for different research, economic, political or survival reasons. Since remains a hazardous environment humans, exploration exploitation requires the development deployment of effective countermeasures. In this paper, we discuss prospects enhancement by gene editing, synthetic biology, implants, purposes future missions. We argue that there are good reasons consider such options, ethical arguments can made in favor enable...
The translation of a capped, polyadenylated RNA after Injection Into the nucleus Xenopus oocytes occurs only If contains an Intron. A single point mutation In splice donor site prevents translation. Intron-less is exported efficiently to cytoplasm and Is held, undegraded, translatlonally Inert state for several days. Translation can be activated by treating with progesterone or Injecting antibodies that bind FRGY2 class messenger binding proteins, p56 p60, but these are effective if...
Hemodynamic forces such as fluid shear stress have been shown to modulate the activity of an expanding family genes involved in vessel wall homeostasis and pathogenesis vascular disease. We investigated effect on tissue factor (TF) gene expression human endothelial cells (ECs) a rat arterial model occlusion. As measured by reverse transcriptase polymerase chain reaction, exposure ECs 1.5 N/m2 resulted time-dependent induction endogenous TF transcripts over 5-fold. Transient transfection...