A5100650925- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Urticaria and Related Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Insects and Parasite Interactions
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Ecology and Conservation Studies
- Eosinophilic Esophagitis
- Pharmacovigilance and Adverse Drug Reactions
- Respiratory viral infections research
- Diverse Approaches in Healthcare and Education Studies
- Anesthesia and Sedative Agents
- Healthcare and Venom Research
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Health and Wellbeing Research
- Indoor Air Quality and Microbial Exposure
- Autoimmune Bullous Skin Diseases
- Neonatal Respiratory Health Research
Yonsei University
2016-2025
Severance Hospital
2012-2024
Deutsches Herzzentrum der Charité
2024
Hallym University
2012-2024
Chuncheon Sacred Heart Hospital
2024
Korea Advanced Institute of Science and Technology
2021-2024
Kyonggi University
2024
Charité - Universitätsmedizin Berlin
2004-2024
Chonnam National University Hospital
2009-2024
Yonsei University Health System
2021-2024
This article was originally published online on 19 November 2009 Asia Pacific Association of Allergology and Clinical Immunology. Commonwealth Independent States (CIS). European Academy Allergy Immunology (EAACI). Latin American Society Interasma (International Asthmology). Albanian South Africa. Allergy, Asthma College Argentine Australasian Allergy. Bangladesh Belgian Brazilian Immunopathology. British for Bulgarian National Allergology. China Chinese Allergists. Cuban Czech Finnish French...
Asthma is a heterogeneous airway disease with various clinical phenotypes. It crucial to clearly identify phenotypes achieve better asthma management. We used cluster analysis classify the groups of 724 asthmatic patients from Cohort for Reality and Evolution Adult in Korea (COREA), 1843 subjects another independent Korean cohort Soonchunhyang University Genome Research Centre (SCH) (Bucheon, Republic Korea). Hierarchical was performed by Ward's method, followed κ-means analysis. Cluster...
Background Coronavirus disease 2019 (COVID-19) has spread worldwide rapidly. However, the effects of asthma, asthma medication and severity on clinical outcomes COVID-19 have not yet been established. Methods The study included 7590 de-identified patients, who were confirmed to using severe acute respiratory syndrome coronavirus 2 RNA-PCR tests conducted up May 15, 2020; we used linked-medical claims data provided by Health Insurance Review Assessment Service. Asthma (steps suggested Global...
Significance Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Genome sequencing studies have provided comprehensive CRC genomic datasets; however, functional validation for most candidate driver genes has not been performed. Here, we describe a platform functionally validating that utilizes CRISPR-Cas9 in mouse intestinal tumor organoids and human CRC-derived organoids. These showed Acvr1b , Acvr2a Arid2 could function as suppressors CRC. We also show co-occurrent...
Abstract The effectiveness of targeting IL-13 in models where airway hyperresponsiveness (AHR) and inflammation have already been established is not well-described. We investigated the effects blocking on early late phase responses development AHR previously sensitized challenged mice. BALB/cByJ mice were (days 1 14) 28–30) with OVA. Six weeks later (day 72), sensitized/challenged a single OVA aerosol response determined. Specific vivo blockade was attained after i.p. injection soluble...
Abstract Respiratory syncytial virus (RSV) infection in early life is suspected to play a role the development of postbronchiolitis wheezing and asthma. Reinfection common at all ages, but factors that determine altered airway function after reinfection are not well understood. This study was conducted mouse model define age determining consequences on reinfection. Mice were infected shortly birth or weaning reinfected 5 wk later, followed by assessment function, inflammation, lung...
Impulse Oscillometry (IOS) was developed as a tool to measure lung function, and it only requires passive cooperation, has been successfully used in younger children. The aim of this study assess the utility IOS compared conventional spirometry for function measures asthmatic Korean children aged 3 6 yrs. Total serum IgE levels, total eosinophil counts, specific levels were measured 77 with asthma 55 control subjects. performed before after bronchodilator administration. Asthmatic...
A method for the detection of rare adducts in DNA has been developed by combining resolution high-performance liquid chromatography with specificity and sensitivity electrochemical detection. Many are electrochemically active, while normal bases, except guanine, not. Enzymatic hydrolysis is used to obtain deoxynucleosides analysis, or where appropriate, acid thermal depurination free adduct base analysis. Various types damage have induced vitro exposure acrolein, dimethyl sulfate, sodium...
Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the locus control region (LCR). To examine in vivo function of LCR, we generated CD4-specific LCR-deficient (cLCR KO) mice using Cre-LoxP recombination. The number CD4 T cells cLCR KO was comparable to wild-type mice. expression cytokines dramatically reduced vitro-stimulated naïve cells. Deletion LCR led a loss general histone H3 acetylation and H3-K4 methylation, demethylation DNA...
The aim of the present study was to investigate relationship between three major allergic diseases, asthma, rhinitis (AR), and atopic dermatitis (AD), psychological behavioural problems in preschoolers based on a community survey.A cross-sectional survey conducted using modified International Study Asthma Allergies Childhood questionnaire determine prevalence symptoms diagnosed Korean version Child Behaviour Checklist assess internalizing, externalizing, sleep among 780 preschoolers....
Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among most important agents involved adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J Allergy Clin Immunol 113:832-836, 2004]. Most studies published date deal mainly with beta-lactam group, information on each other antimicrobial is scarce. The present document has been produced by Special Committee Drug World Organization relevant...
Determining the culprit allergen is important for diagnosis and management of allergic diseases. The skin prick test (SPT) has been widely used to identify allergens. Skin reactivity allergens changed due changes in lifestyle outdoor environments. Therefore, aim present paper was examine sensitization Korea. We enrolled 1,135 patients with respiratory diseases who were diagnosed at Severance Hospital from January 2010 December 2011. SPTs performed inhalant allergens, compared our previous...
Silica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation their potential toxicity. This study examined effects acute exposure to SNPs, either alone or conjunction with ovalbumin (OVA), by studying respiratory systems exposed mouse models. Three types SNPs were used: spherical (S-SNPs), mesoporous (M-SNPs), PEGylated (P-SNPs). In SNP model performed, 6-week-old BALB/c female mice intranasally inoculated for 3 consecutive days....
Understanding the mechanism behind immune cell plasticity in cancer metastasis is crucial for identifying key regulators. Previously we found that mitotic factors regulate epithelial-mesenchymal transition, but how these convert to metastatic players tumor microenvironment (TME) not fully understood.The clinical importance of was analyzed by heatmap analysis, a KM plot, and immunohistochemistry lung adenocarcinoma (LUAD) patients. Immunoprecipitation, LC-MS/MS, kinase assay, site-directed...
Buckwheat (BW) has been recognized as a common food allergen in Korea, Japan, and other countries. Until now, serologic findings of BW food-allergic patients its major allergenic components have not clarified. In this study, we analyzed the allergy characterized components.Nineteen BW-allergic subjects with symptoms after ingestion 15 asymptomatic control positive skin prick test to were recruited. BW-specific IgE was measured Pharmacia CAP kit. Allergenic by immunoblotting, periodate...
Abstract The role of Th2/CD4 T cells, which secrete IL-4, IL-5, and IL-13, in allergic disease is well established; however, the CD8+ cells (allergen-induced airway hyperresponsiveness (AHR) inflammation) less clear. This study was conducted to define Ag-primed development these allergen-induced responses. CD8-deficient (CD8−/−) mice wild-type were sensitized OVA by i.p. injection then challenged with via airways. Compared mice, CD8−/− developed significantly lower responsiveness inhaled...