A5019899932- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Cystic Fibrosis Research Advances
- Airway Management and Intubation Techniques
- Atomic and Subatomic Physics Research
- Transplantation: Methods and Outcomes
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Dysphagia Assessment and Management
- Pneumonia and Respiratory Infections
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular and exercise physiology
Fluidda (Belgium)
2012-2021
Fluidda (United States)
2013-2021
Trudell Medical International (Canada)
2021
Antwerp University Hospital
2016
University College Ghent
2010-2014
Ziekenhuis Oost-Limburg
2013
The Alfred Hospital
2013
The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development inflammation followed by fibrotic tissue changes represents the most widely used model pulmonary fibrosis investigate human IPF. Histopathology is gold standard for assessing lung rodents, however it precludes repeated longitudinal measurements disease progression does not provide information on spatial temporal distribution damage. Here we investigated use Micro-CT technique...
The efficacy of inhaled corticosteroids (ICS) in moderately severe COPD patients remains unclear. At the same time, use extrafine particles is a topic ongoing research.This study assessed effect ICS steroid-naïve mild and reducing dose more previously using when switching to an particle BDP/F formulation (Foster Modulite technology, Chiesi Pharmaceutici, Parma, Italy).Novel functional respiratory imaging (FRI) methods, consisting multi-slice CT scans Computational Fluid Dynamics, were used...
Context: Asthma affects 20 million Americans resulting in an economic burden of approximately $18 billion the US alone (Allergies and Foundation 2000; National Center for Environmental Health (NCEH) 1999). Research studies based on differences patient-specific airway morphology asthma associated effect deposition inhaled aerosols are currently not available literature. Therefore, role morphological variations such as upper (extrathoracic) occlusion is well documented.Objective: Functional...
Inhaled formulations using extrafine particles of long-acting β2-agonists and corticosteroids were developed to optimize asthma treatment. Findings that these combinations reach treat smaller airways more effectively are predominantly based on general non-specific outcomes with little information regional characteristics.This study aims assess long-term effects beclomethasone/formoterol small asthmatic patients novel functional imaging methods.Twenty-four stable subdivided into three groups...
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification of chronic obstructive pulmonary disease (COPD) does not always match with other clinical descriptors such as exacerbation frequency and quality life, indicating that forced expiratory volume in 1 s (FEV ) is a perfect descriptor the disease. aim this study was to find out whether changes airway geometry after inhalation most commonly used therapy severe COPD can more adequately be described an image-based...
Background Pseudomonas aeruginosa (Pa) infection is an important contributor to the progression of cystic fibrosis (CF) lung disease. The cornerstone treatment for Pa use inhaled antibiotics. However, there substantial disease heterogeneity within and between patients that likely impacts deposition patterns Therefore, this may result in airways below minimal inhibitory concentration agent. Very little known about antibiotic concentrations small airways, particular effect structural...
Introduction: Severe chronic obstructive pulmonary disease (COPD) is often associated with secondary hypertension (PH), which worsens prognosis. PH can be lowered by oxygen, but also inhaled nitric oxide (NO), has the potential to improve health status of these patients. NO an important mediator in vascular reactions circulation. Oral compounds act through NO-mediated pathways, delivering pulsed (iNO) directly airways and vasculature could equally benefit Therefore, a proof-of-concept study...
The obstructive sleep apnea-hypopnea syndrome (OSAHS) is a related breathing disorder. A popular treatment the use of mandibular repositioning appliance (MRA) which advances mandibula during and decreases collapsibility upper airway. success rate such device is, however, limited very variable within population patients. Previous studies using computational fluid dynamics have shown that there decrease in airway resistance patients who improve clinically due to an MRA. In this article,...
Background: Previous studies have demonstrated the potential beneficial effect of N-acetylcysteine (NAC) in chronic obstructive pulmonary disease (COPD). However, required dose and responder phenotype remain unclear. The current study investigated high-dose NAC on airway geometry, inflammation, oxidative stress COPD patients. Novel functional respiratory imaging methods combining multislice computed tomography images computer-based flow simulations were used with high sensitivity for...
As the upper airway is most important limiting factor for deposition of inhalation medication in lower airways, it interesting to assess how its morphology varies between different postures. The goal this study compare and functionality healthy volunteers upright supine positions during tidal nasal breathing search baseline indicators these changes. This done by performing three-dimensional measurements on computed tomography (CT) cone beam (CBCT) scans.This prospective was approved all...
To compare lobar lung ventilation computed from expiratory and inspiratory tomographic (CT) data with direct measurements of at hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging by using same-breath hydrogen 1 ((1)H) MR examinations to coregister the multimodality images.The study was approved national research ethics committee, written patient consent obtained. Thirty patients asthma underwent breath-hold CT total capacity functional residual capacity. (3)He (1)H images were...
Introduction: There is a clear correlation between small airways dysfunction and poor clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), it therefore important that inhalation therapy (both bronchodilator anti-inflammatory) can deposit the airways. Two single-inhaler triple (SITT) combinations are currently approved for maintenance treatment of COPD: extrafine formulation beclomethasone dipropionate/formoterol fumarate/glycopyrronium bromide (BDP/FF/GB),...
Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of study was identify FRI parameters, which predict FVC decline in patients IPF. An IPF-cohort (treated pamrevlumab for 48 weeks) retrospectively studied using FRI. Serial CT's were compared from 66 subjects. Post-hoc analysis performed FRI, and mixed effects models. Lung volumes,...
Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA Wim Vos,1 Bita Hajian,2 Jan De Backer,1 Cedric Van Holsbeke,1 Samir Vinchurkar,1 Rita Claes,2 Annemie Hufkens,2 Paul M Parizel,3 Lieven Bedert,4 Wilfried Backer2 1FLUIDDA nv, Groeningenlei, Kontich, 2Department of Respiratory Medicine, 3Department Radiology, University Hospital Antwerp, Wilrijkstraat, Edegem, 4Department ZNA Middelheim Hospital, Belgium Background: Patients with...
Abstract Introduction High‐frequency chest wall oscillation (HFCWO) is a commonly prescribed airway clearance technique (ACT) for patients whose ability to expectorate sputum compromised. This study aimed assess the effectiveness of newly developed mobile ACT device (mHFCWO—The Monarch Airway Clearance System) in with cystic fibrosis (CF). A standard nonmobile HFCWO (sHFCWO) was used as comparator. Methodology randomized, open‐label, crossover pilot study. CF were treated each device. Sputum...
Unambiguously for inhaled products, PK measures are best suited ensuring that the total systemic exposure is equivalent two products but cannot provide regional information about lung deposition and structural changes. Functional respiratory imaging (FRI) has been demonstrated to be sensitive distinguishing small imperative differences related a single treatment.In this study FRI used in 16 asthmatic patients assess equivalence (fluticasone/salmeterol, test reference) by directly measuring...
A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler co-suspension delivery technology in patients with COPD Wilfried De Backer,1 Jan Backer,2 Wim Vos,3 Ilse Verlinden,3 Cedric Van Holsbeke,3 Johan Clukers,1 Bita Hajian,1 Shahid Siddiqui,4 Martin Jenkins,5 Colin Reisner,4,6 Ubaldo J Martin4 1Department Respiratory Medicine, University Antwerp, Belgium; 2FLUIDDA, Los Angeles,...
Background: Functional respiratory imaging (FRI) uses three-dimensional models of human lungs and computational fluid dynamics to simulate functional changes within airways predict the deposition inhaled drugs. This study used FRI model effects different patient inhalation drug formulation factors on lung an corticosteroid/long-acting β 2 -agonist (ICS/LABA) combination, administered by a pressurized metered-dose inhaler. Methods: Three-dimensional six patients with asthma (mean forced...
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD).To develop novel, induced sputum endpoints to demonstrate changes in neutrophil phenotype lung by administering nemiralisib, a potent and selective inhaled PI3Kδ inhibitor, stable COPD or acute exacerbation (AE) COPD.In two randomized, double-blind, placebo-controlled clinical trials A)...
This study evaluated the safety and efficacy of inhaled nemiralisib, a phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, in patients with an acute exacerbation chronic obstructive pulmonary disease (COPD).In this double-blind, placebo-controlled study, 126 (40-80 years post-bronchodilator forced expiratory volume 1 sec (FEV1) ≤80% predicted (previously documented)) were randomized 1:1 to once daily nemiralisib (1 mg) or placebo for 84 days, added standard care. The primary endpoint was specific...