A5028296748- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational exposure and asthma
- Indoor Air Quality and Microbial Exposure
- Allergic Rhinitis and Sensitization
- Ergonomics and Musculoskeletal Disorders
- Occupational Health and Safety Research
- Musculoskeletal pain and rehabilitation
- Workplace Health and Well-being
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Contact Dermatitis and Allergies
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Odor and Emission Control Technologies
- Employment and Welfare Studies
- Pleural and Pulmonary Diseases
- Education, Healthcare and Sociology Research
- Food Allergy and Anaphylaxis Research
- School Health and Nursing Education
- Effects of Vibration on Health
- Sleep and Work-Related Fatigue
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Aalborg University Hospital
2014-2024
Danish Ramazzini Center
2012-2022
Aalborg University
2011-2021
Imperial College London
2020
Royal Brompton Hospital
2020
Finnish Institute of Occupational Health
2020
Aarhus University
2004-2017
Faculty (United Kingdom)
2013-2016
Aarhus University Hospital
1985-2014
Svendborg Sygehus
2007-2012
Background Recent studies have shown that in several countries atopic sensitization to common allergens (common atopy) and symptoms are markedly less prevalent children living on a farm, compared with non‐farm the same rural areas. Living conditions farms may, however, vary largely between different countries. It is also not yet known whether ‘protective’ effect of farm environment can be found adults. Materials methods Common atopy respiratory health were assessed by skin prick tests (SPT),...
Fatigue can develop during prolonged computer work, particularly in elderly individuals. This study investigated eye movement characteristics relation to fatigue development. Twenty young and 18 healthy adults were recruited perform a functional task while their movements recorded. The lasted 40 minutes involving 240 cycles divided into 12 segments. Each cycle consisted of sequence memorization pattern, washout period, replication the pattern using mouse. participants rated perceived after...
Summary Background Evidence exists that exposure to high levels of microbial agents such as endotoxin in the farm environment decreases risk atopic sensitization. Genetic variation innate immunity genes may modulate response and thus influence susceptibility asthma atopy. Objective To study potential associations between single nucleotide polymorphisms (SNPs) CD14, Toll‐like receptor 2 (TLR2), TLR4 genes, atopy new‐onset young farmers. Methods A nested case–control was conducted within a...
The reported prevalence of allergic sensitization among children is lower in rural areas than urban the world. aim was to investigate urban-rural differences inhalant allergens adults depending on childhood exposure living an industrialized country as Denmark.A total 1236 male participants 30-40 years age recruited from two epidemiological studies were divided into four groups with regard place upbringing; city, town, area and farm. Allergic assessed by skin prick tests (SPTs) 10...
Studies on determinants of dairy farmers’ exposure to dust and endotoxin have been sparse so far none has addressed the combined effect tasks farm characteristics. To study whether how work specific stable characteristics influence level personal inhalable endotoxin. We applied an observational design involving full-shift repeated measurements among 77 subjects (owners workers) from 26 farms. Performed were self-registered in activity diaries, information was collected through interviews...
Chronic obstructive pulmonary disease (COPD) is one of the leading causes disability and death in world. Many people with are undiagnosed or untreated due to lack consensus about definition COPD. The objective was estimate prevalence COPD Danish population aged 45-84 years identify proportion persons not receiving appropriate medical treatment. A population-based study two counties (population = 299,000 persons) based on data from 155 general practices 2004-2006 period. Stratified sampling...
Studies on personal dust and endotoxin concentrations among animal farmers have been either small or limited to a few sectors in their investigations. The present study aimed provide comparable information the levels variability of exposure different types farmers. 507 inhalable samples were collected from 327 employed 54 pig, 26 dairy, 3 poultry, mink farms Denmark. Measurements pig dairy full-shift performed during summer winter, while poultry monitored 4 well-defined production stages....
To test the hypotheses that current endotoxin exposure is inversely associated with allergic sensitisation and positively non-allergic respiratory diseases in four occupationally exposed populations using a standardised analytical approach.Data were pooled from epidemiological studies including 3883 Dutch Danish employees veterinary medicine, agriculture power plants biofuel. Endotoxin was estimated by quantitative job-exposure matrices specific for study populations. Dose-response...
The sensitivity of oculometrics to the changes in mental load has already been investigated several studies. However, reliability remains unexplored, particularly under concurrent demands. To address this, we recruited 20 young and 18 elderly healthy adults perform a functional computer task with three levels (i.e., low, medium, high) on two days interspaced by at least seven days. We tracked participants' eye movements pupil size during computed characterizing features saccades, fixations,...
The aim of this study was to assess the prevalence asthma (self-reported) and relate lung function factors associated with in young farmers. Two hundred ten female 1,691 male farming students together 407 males controls were studied. Each subject underwent a medical interview; forced expiratory volume one second (FEV1) vital capacity (FVC) recorded using dry wedge spirometer. Histamine bronchial reactivity measured Yan method. Skin prick testing performed inhalant allergens. Nonsmokers had...
Several studies have found an association between the rare Pi-alleles and asthma or bronchial hyperresponsiveness (BHR). This study deals with effect of Pi-type on BHR among 2,308 young Danish people living in rural areas a mean +/- SD age 19.7+/-2.4 yrs. Interviews, pulmonary function testing, histamine provocation skin-prick tests were performed. Serum alpha1-antitrypsin levels determined phenotyping was performed by means isoelectric focusing subjects categorized into four groups: 1) MM...
Exposure to polycyclic aromatic hydrocarbons (PAHs) in foundry workers has been evaluated by determination of benzo(a)pyrene-serum albumin adducts and urinary 1-hydroxypyrene. Benzo(a)pyrene binding 1-hydroxypyrene were quantitatively measured enzyme linked immunosorbent assay (ELISA) reverse phase high performance liquid chromatography (HPLC), respectively. 70 male 68 matched controls investigated. High low exposure groups defined from breathing zone hygienic samples, consisting 16 PAH...
Aims: Various social and economic effects are associated with asthma. This quantitative study describes the of current asthma on work life evaluated from number weeks receiving transfer incomes. Methods: The population comprised 7,241 persons answering ECRHS II screening questionnaire, which was sent to a random age gender stratified sample 10,000 aged 20 44 years. Participants were identified by positive answers set validated questions. Transfer incomes for five-year period registered...
Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy rare among women and studies of the prevalence causative role non-occupational exposure with MM are scarce. This observational study aimed to elucidate patterns MM. Methods All histological cytological specimens from diagnosed between 1974–2015 at Institute Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational habitation information obtained Danish registries...
Abstract Background Numerous cross-sectional studies have reported reduced lung function among welders but limitations of exposure assessment and design preclude causal inference. The aim this study was to investigate if long-term welding fume particulates accelerates the age-related decline in function. Methods Lung measured by spirometry 1987 2004 68 steel 32 non-welding production workers. forced expiratory volume (FEV 1 ) analysed relation cumulated during follow-up period. Results Among...
Occupational exposures have been shown to be risk factors for chronic obstructive pulmonary disease (COPD) among never-smokers. In a Danish population-based cohort, we analysed this association and the population attributable fraction. The study (N=1575) was aged 45-84, COPD defined by lung function measurements method of lower limit normal (LLN), occupational exposure assessed questionnaire expert judgement. Furthermore, estimates additionally were provided according Global Initiative...
Musculoskeletal pain from the upper extremity and shoulder region is commonly reported by computer users. However, functional status of central mechanisms, i.e., sensitization conditioned modulation (CPM), has not been investigated in this population. The aim was to evaluate CPM users with without chronic musculoskeletal pain. Pressure threshold (PPT) mapping neck-shoulder (15 points) elbow (12 assessed together PPT measurement at mid-point tibialis anterior (TA) muscle among 47 and/or (pain...
Objectives To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming wood industry. Methods We studied COPD (1997–2013) individuals born during 1950–1977 Denmark ever or industry (n=1 75 409). Industry-specific employment history (1964–2007), combined with time-dependent industry-specific matrices defined exposure. used logistic regression analysis discrete survival...
The purpose of this study was to examine whether the resistance peak flow meter influences its recordings. One hundred and twelve subjects, (healthy nonsmokers smokers subjects with lung diseases) performed three or more expiratory (PEF) manoeuvres through a Fleisch pneumotachograph without mini-Wright added in random order as series. results were follows. In comparison alone, measured an had smaller within-test variation, defined difference between highest second values PEF series blows....