A5060247850- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cancer, Lipids, and Metabolism
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Sports injuries and prevention
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Cardiac Arrest and Resuscitation
- Cholesterol and Lipid Metabolism
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Lipid metabolism and disorders
Aarhus University Hospital
2016-2025
Aarhus University
2016-2025
ERN GUARD-Heart
2024-2025
Skive Hospital
2024
Copenhagen University Hospital
2004-2022
Rigshospitalet
1966-2022
Institute for Molecular Medicine Finland
2022
Tufts Medical Center
2022
McGill University Health Centre
2022
H. Henriksen (Norway)
2012-2021
Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between levels, inhibition, and cardiovascular risk reduction remains undefined.Lp(a) was measured 25 096 patients FOURIER trial (Further Cardiovascular Outcomes Research with Inhibition Subjects Elevated Risk), randomized of evolocumab versus placebo established...
AimsTo compare left ventricular function after a long-term His or para-His pacing (HP) and right septal (RVSP) in patients with atrioventricular block (AVB).
A method for estimating total bone calcium is reported. The based on two-dimensional scanning photon absorptiometry the distal part of forearm. following factors are investigated: precision measurements standards and human subjects; linearity; effect varying orientation; amount fat soft tissue; relation between weight content phosphate. results show that eminently suitable rapid, easy, atraumatic measurement local in vivo.
AimsTo provide a comprehensive histopathological validation of cardiac magnetic resonance (CMR) and endocardial voltage mapping acute chronic atrial ablation injury.
The aim of the study was to evaluate safety and efficacy left atrial appendage occlusion (LAAO) with AMPLATZER Cardiac Plug (ACP) or Amulet using aspirin alone (ASA) as post-implantation antithrombotic treatment.This a single-centre, prospective, non-randomised on LAAO ACP in consecutive cohort (n=110) treated by ASA post implantation. primary outcome device-related thrombosis, while secondary outcomes were ischaemic stroke major bleeding. Clinical follow-up conducted after six weeks 12...
Abstract Patients with short QT syndrome (SQTS) may present syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain <25% of cases. Here we identify a missense mutation in the anion exchanger (AE3)-encoding SLC4A3 gene two unrelated families SQTS. The causes reduced surface expression AE3 and membrane bicarbonate transport. Slc4a3 knockdown zebrafish increased pH i , QTc, systolic duration, which is rescued by wildtype but...
<h3>Importance</h3> Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) have been implicated the pathobiology AS. The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab reduces circulating LDL-C concentrations by 50% to 60% Lp(a) 20% 30%. <h3>Objective</h3> To determine whether risk events patients...
Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ectopy in response to catecholamine stress, which can be reproduced on exercise stress testing (EST). However, reports of sudden cardiac death (SCD) have emerged EST-negative individuals who loss-of-function (LOF) RyR2 mutations. The clinical relevance LOF including their pathogenic mechanism, diagnosis, and treatment are all...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) causes arrhythmias (VAs) and sudden cardiac death (SCD). In 2019, a risk prediction model that estimates the 5-year of incident VAs in ARVC was developed (ARVCrisk.com). This study aimed to externally validate this large international multicentre cohort compare its performance with factor approach recommended for implantable cardioverter-defibrillator (ICD) use by published guidelines expert consensus.In retrospective 429 individuals...
Population-based epidemiologic studies of aortic dissections (ADs) are needed. This study aimed to report clinical characteristics, incidences, and mortality rates for adult patients admitted Danish hospitals with type A AD (TAAD) or B (TBAD) from 1996 through 2016.We conducted a nationwide, population-based register study. All cases registered International Classification Diseases, Tenth Revision codes in the National Patient Registry at time admission hospital available medical records...
Abstract Aims Calmodulinopathy due to mutations in any of the three CALM genes (CALM1–3) causes life-threatening arrhythmia syndromes, especially young individuals. The International Registry (ICalmR) aims define and link increasing complexity clinical presentation underlying molecular mechanisms. Methods results ICalmR is an international, collaborative, observational study, assembling analysing genetic data on CALM-positive patients. has enrolled 140 subjects (median age 10.8 years...
Abstract Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences utilization of primary prevention ICDs survival free from sustained arrhythmia (VA) ARVC. Methods was a retrospective analysis ARVC patients without prior VA enrolled clinical registries 11 countries throughout Europe North America. Patients were...
In patients with Ebstein's anomaly (EA) arrhythmias are frequently encountered. Although most can be targeted catheter ablation, specific issues render the procedure more challenging in EA. This study examines mechanisms of different related to EA and outcome after ablation.Clinical procedural data ablation 4 European centers were analyzed. 32 (mean age 24 ± 15 years), 34 accessory pathways (APs), 8 intra-atrial reentry tachycardias (IART), 5 cavotricuspid isthmus-dependent atrial flutter...
Abstract Background Atrial fibrillation (AF) is the most common arrhythmia. The potassium current I Ks essential for cardiac repolarization. Gain-of-function mutations in K V 7.1, pore-forming α-subunit of channel, have been associated with AF. We hypothesized that early-onset lone AF channel regulatory subunit KCNE1. Methods In 209 unrelated patients (< 40 years) entire coding sequence KCNE1 was bidirectionally sequenced. analyzed identified mutants electrophysiologically heterologous...
This study evaluates the agreement between echocardiographic and cardiac magnetic resonance (CMR) imaging data, impact a discrepancy two may have on clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). From Nordic ARVC Registry, 102 patients with definite who had undergone both echocardiography CMR were included (median age 42 ± 16 years, 36% female, 78% probands). Patients divided into groups according to CMR-positive or -negative criteria, data compared two. There...
<h3>Importance</h3> Calcium-release deficiency syndrome (CRDS), which is caused by loss-of-function variants in cardiac ryanodine receptor 2 (RyR2), an emerging cause of ventricular fibrillation. However, the lack complex polymorphic/bidirectional tachyarrhythmias during exercise stress testing (EST) may distinguish it from catecholaminergic polymorphic tachycardia (CPVT). Recently, first clinical series describing condition, mouse and human studies showed that long-burst, long-pause,...
We used tissue velocity imaging (TVI) and three-dimensional echocardiography to evaluate the effect of acute biventricular pacing on left ventricular (LV) performance volumes in patients with severe heart failure bundle branch block.Biventricular causes hemodynamic improvement failure, QRS duration has been as a predictor improved resynchronization. Tissue potential demonstrating degree LV resynchronization enables accurate quantitation function.TVI were performed during sinus rhythm 25...