A5045565573- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Odor and Emission Control Technologies
- Occupational exposure and asthma
- Infection Control and Ventilation
- Air Quality Monitoring and Forecasting
- Mycotoxins in Agriculture and Food
- Allergic Rhinitis and Sensitization
- Conservation Techniques and Studies
- Building materials and conservation
- Plant Pathogens and Fungal Diseases
- Antimicrobial Resistance in Staphylococcus
- Nanoparticles: synthesis and applications
- Bacterial Identification and Susceptibility Testing
- Microbial Community Ecology and Physiology
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Infection Control in Healthcare
- Entomopathogenic Microorganisms in Pest Control
- Insect and Pesticide Research
- Plant Pathogens and Resistance
- Food Safety and Hygiene
- Clostridium difficile and Clostridium perfringens research
National Research Centre for the Working Environment
2016-2025
Karolinska University Hospital
2023
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
2021
Technical University of Denmark
2021
Danish National Centre for Social Research
2017-2020
Nationale Instelling voor Radioactief Aval en verijkte Splijtstoffen
2016
Aarhus University
2015
Oregon State University
2012
National Institute of Occupational Health
2006
Danish National Institute of Public Health
2003
ABSTRACT Indoor microbial exposure has been related to adverse pulmonary health effects. Exposure assessment is not standardized, and various factors may affect the measured exposure. The aim of this study was investigate seasonal variation selected exposures their associations with temperature, relative humidity, air exchange rates in Danish homes. Airborne inhalable dust sampled five homes throughout four seasons 1 year (indoors, n = 127; outdoors, 37). Measurements included culturable...
Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about genotoxicity various organs vivo.We investigated inflammatory and acute phase responses, DNA strand breaks (SB) oxidatively damaged C57BL/6 mice 1, 3 28 days after a single instillation of 0.018, 0.054 or 0.162 mg Printex 90 CBNPs, alongside sham controls. Bronchoalveolar lavage (BAL) fluid was analyzed for cellular composition. SB BAL...
Indoor microbial exposure has been related to allergy and respiratory disorders. However, the lack of standardized sampling methodology is problematic when investigating dose-response relationships between health effects. In this study, different methods were compared regarding their assessment exposures, including culturable fungi bacteria, endotoxin, as well total inflammatory potential (TIP) dust samples from Danish homes. The Gesamtstaubprobenahme (GSP) filter sampler BioSampler used for...
Little is known of how the toxicity nanoparticles affected by incorporation in complex matrices. We compared toxic effects titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded a paint matrix. also same with and without NanoTiO2. Mice received single intratracheal instillation 18, 54 162 μg NanoTiO2 54, 486 sanding dust from DNA damage broncheoalveolar lavage cells liver, lung inflammation liver histology were evaluated 1, 3 28 days after instillation. Printex 90 was...
Particulate air pollution is associated with cardiovascular disease. Acute phase response causally linked to Here, we propose that particle-induced pulmonary acute provides an underlying mechanism for risk.
This cross-sectional study investigated the relationship between exposure to airborne indoor and outdoor particulate matter (PM) cardiovascular respiratory health in a population-based sample of 58 residences Copenhagen, Denmark. Over 2-day period particle number concentrations (PNC, 10–300 nm) PM2.5 (aerodynamic diameter < 2.5 μm) were monitored for each living room, PNC (10–280 nm), PM10 10 at an urban background station Copenhagen. In morning, after monitoring period, we measured...
Graphene and graphene oxide receive much attention these years, because they add attractive properties to a wide range of applications products. Several studies have shown toxicological effects other carbon‐based nanomaterials such as carbon black nanoparticles nanotubes in vitro vivo. Here, we report in‐depth physicochemical characterization three commercial materials, one (GO) two reduced oxides (rGO) assess cytotoxicity genotoxicity the murine lung epithelial cell line FE1. The studied GO...
Fungi living inside plants affect many aspects of plant health, but little is known about how genotype influences the fungal endophytic microbiome. However, a deeper understanding interactions between and biotic abiotic environment in shaping microbiome significance for modern agriculture, with implications disease management, breeding development biocontrol agents. For this purpose, we analysed wheat from seed to seeds studied different potential sources inoculum contributed We conducted...
Nanomaterial (NM) characteristics may affect the pulmonary toxicity and inflammatory response, including specific surface area, size, shape, crystal phase or other characteristics. Grouping of TiO2 in hazard assessment might be challenging because variation physicochemical properties. We exposed C57BL/6 J mice to a single dose four anatase NMs with various sizes shapes by intratracheal instillation assessed 1, 3, 28, 90 180 days post-exposure. The quartz DQ12 was included as benchmark...
The bacterial phylum Gemmatimonadetes contains members capable of performing bacteriochlorophyll-based phototrophy (chlorophototrophy). However, only one strain chlorophototrophic bacteria (CGB) has been isolated to date, hampering our further understanding their photoheterotrophic lifestyle and the evolution in CGB. By combining a culturomics strategy with rapid screening technique for chlorophototrophs, we report isolation new member CGB, Gemmatimonas (G.) groenlandica sp. nov., from...
Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon (MWCNT) with varying properties identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM‐401, NM‐402, NM‐403), materials (NRCWE‐026 MWCNT‐XNRI‐7), three sets surface‐modified grouped by physical characteristics (thin, thick, short I–III, respectively). Each Groups I–III pristine, hydroxylated...
The importance of the microbial diversity bioaerosols in relation to occupational exposure and work related health symptoms is not known. aim this paper gain knowledge on bacterial fungal communities dust causing organic toxic syndrome (ODTS) reference ODTS. Bacterial were described personal samples from grass seed workers developing ODTS, generated seeds ODTS Amplicon sequencing 16S rRNA gene ITS region, as well matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) used for...
To explore associations of exposure to ambient and indoor air particulate bio-aerosol pollutants with cardiovascular respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) surfactant protein-D (SPD) were examined relation preceding each measurement....
We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and following day co-housed mature males, in breeding pairs. Time delivery first litter, litter parameters, maternal inflammation histopathology lung liver recorded. In male offspring, locomotor activity, startle response, daily sperm production (DSP) assessed. dams, bore evidence MWCNT when assessed 6 weeks 4 months...
The aim of this study was to obtain knowledge about concentrations Staphylococcus aureus, MRSA (methicillin-resistant S. aureus), and other species in indoor air Greater Copenhagen factors affecting the concentrations. effects season, temperature, relative humidity, change rate (ACR), bacterial genera, area per occupant, presence aureus-positive occupants were studied. In samples from 67 living rooms, hominis, warneri, epidermidis, capitis found 13-25%; saprophyticus, cohnii, pasteuri 5-10%;...
A large number of people work with garbage collection, and exposure to microorganisms is considered an occupational health problem. However, knowledge on microbial at species level limited. The aim the study was achieve waste collectors' airborne inhalable fungal bacterial during collection focus transport into truck cab. Airborne were collected samplers mounted in cab, workers' clothes, outdoors. Fungal quantified identified. showed that workers exposed between 112 4.8×10(4) bacteria m(-3)...
Transmission of methicillin-resistant Staphylococcus aureus (MRSA) from animals to humans is great concern due the implications for human health and care system. The objective was investigate frequency duration MRSA carriage in volunteers after a short-term exposure swine farm. experimental study included 34 staying 1 h MRSA-positive farm four trials. In two trials, influence work involving pig contact studied using crossover design. quantities nasal swabs, throat air samples were measured...
Bioaerosol exposure is associated with health problems. The aim of this study to evaluate whether it possible assess the risks posed by waste collection workers' through identification and characterization bacterial fungal species, which workers are exposed. Using MALDI-TOF MS, microorganisms in air, hand, contact steering wheel were identified. Fungi found high concentrations from characterized for total inflammatory potential (TIP), cytotoxicity, biofilm-forming capacity. In total, 180...
The airborne fungal and bacterial species present in pig farm dust have not been well characterised even though these bioaerosols are known to cause inflammation other airway maladies. In this study, the microbial composition within between farms were investigated. Passively sedimenting from six collected using electrostatic collectors. identified matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry (MALDI-TOF MS) next generation sequencing (NGS). Dust samples taken...
Selection of sampling device, location and period are important first steps in the measurement exposure to bioaerosols indoor air. The following include treatment samples laboratory analysis. In this study, settling bacteria, endotoxin, fungi serine protease have been measured Danish homes using Electrostatic Dust Fall Collectors (EDCs). effects presence occupants, on open surfaces versus bookcases studied. Concentrations bacteria endotoxin were significantly higher when occupants at home...
We investigated effects of maternal pulmonary exposure to titanium dioxide (UV-Titan) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were inhalation (1 h/day 42 mg UV-Titan/m3 aerosolised powder or filtered air) during gestation days (GDs) 8–18. evaluated DNA strand breaks using the comet assay in bronchoalveolar lavage (BAL) cells and livers time-mated (5 26–27 after exposure), offspring (post-natal (PND) 2 22). also analysed hepatic gene expression newborns microarrays....