A5053920924- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Nosocomial Infections in ICU
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Neuroendocrine Tumor Research Advances
- Gastroesophageal reflux and treatments
- Neuroblastoma Research and Treatments
- Pregnancy and Medication Impact
- Stoma care and complications
- Reproductive System and Pregnancy
- Colorectal Cancer Surgical Treatments
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Lung Cancer Research Studies
- Glycogen Storage Diseases and Myoclonus
- Intestinal Malrotation and Obstruction Disorders
- Central Venous Catheters and Hemodialysis
- Intestinal and Peritoneal Adhesions
- Poxvirus research and outbreaks
- Patient-Provider Communication in Healthcare
Aarhus University Hospital
2018-2025
Aarhus University
2021-2025
Fecal microbiota transplantation (FMT) is recommended for treatment of recurrent Clostridium difficile infection (rCDI). We performed a single-center randomized trial to compare the effects FMT with those fidaxomicin and vancomycin.We studied consecutive adults rCDI seen at gastroenterology clinic in Denmark from April 5, 2016 through June 10, 2018. Patients were randomly assigned group that received FMT, applied by colonoscopy or nasojejunal tube, after 4-10 days vancomycin (125 mg 4 times...
BackgroundFaecal microbiota transplantation (FMT) is effective for recurrent Clostridioides difficile infection (CDI), but inconsistent effect rates and uncertain evidence levels have warranted caution. To clarify, we aimed to establish the of FMT CDI, updated across different delivery methods, treatment regimens, in comparison with standard antibiotics.MethodsIn this systematic review meta-analysis, searched PubMed, Scopus, Embase, Web Science, Clinical Key, Svemed+ literature published...
Abstract Background Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening faeces donors are being embedded within regulatory frameworks described in European Union Tissue Cells Directive technical guide to quality safety tissue cells human application, published by Council. Objective Several international consensus statements concerning faecal...
Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the use, conduct, potential for FMT in Europe.We invited all hospital-based centres within European Council member states answer a web-based questionnaire covering their activities, organisation, regulation of 2019. Responders were identified from trials registered at clinicaltrials.gov United Gastroenterology (UEG) working group stool...
Introduction Liver cirrhosis is a progressive disease with high mortality. Gut microbiota derangement, increased gut permeability, bacterial translocation and chronic inflammation all drive progression. This trial aims to investigate whether faecal transplantation (FMT) may improve the course in patients acute decompensation of liver cirrhosis. Methods analysis In this Danish, multicentre, randomised, double-blinded, placebo-controlled trial, 220 Child-Pugh score≤12 will be randomised (1:1)...
AbstarctIn fecal microbiota transplantation (FMT) against recurrent Clostridioides difficile infection (CDI), clinical outcomes are usually determined after 8 weeks. We hypothesized that the intestinal changes earlier than this timepoint, and analyzed samples obtained 1 week treatment from 64 patients diagnosed with CDI included in a randomized trial, where was treated either vancomycin-preceded FMT (N = 24), vancomycin 16) or fidaxomicin 24). In comparison non-responders, sustained...
Evidence on ustekinumab safety in pregnancy is gradually expanding, but its clearance the postnatal period unknown. The aim of this study was to investigate concentrations umbilical cord blood and rates after birth, as well how these correlate with maternal drug concentrations, risk infection, developmental milestones during first year life.
Patients with inflammatory bowel disease (IBD) are at an increased risk of developing Clostridioides difficile infection (CDI). Treatment CDI in patients IBD is challenging due to higher failure rates and concomitant activity.We performed a multicentre cohort study who received fecal microbiota transplantation (FMT) for recurrent (rCDI), further investigate factors that influence the clinical outcome course both rCDI IBD.This conducted five European FMT centres.Adult treated were studied....
Abstract Background The pharmacokinetic (PK) profile of vedolizumab during pregnancy is not fully characterised, though concentrations have been reported to drop1.To minimise transplacental transfer, discontinuation in the 3rd trimester has suggested, but this may lead flare IBD and postpartum2. This study aimed characterise changes PK using mathematical modelling explore dosing scenarios guide decisions on 3rd-trimester dosing. Methods A multicenter, prospective, observational was conducted...
Objective To characterise gastrointestinal symptoms and bowel habits in healthy blood donors explore symptom phenotypes their associated factors. Methods Between November 2020 March 2023, 53 046 participants the nationwide Danish Blood Donor Study completed a questionnaire including 13 symptoms, defaecation pattern regularity, stool frequency, consistency. We used data-driven approach to investigated factors by multinomial logistic regression. Results Among (52% women), 68% (95% CI 67.5%...
Abstract Background Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second‐line therapy. Objective The aim was to obtain results of first 108 patients treated with MRgFUS in Denmark. Methods Data were entered a quality assurance database at baseline and 3, 6, 12 months. Clinician‐ patient‐rated treatment efficacy evaluated using Fahn–Marin–Tolosa (FMT) scale Patient Global Impression Change....
Faecal microbiota transplantation (FMT) is an effective treatment for patients with recurrent Clostridioides difficile infection, but donor selection can influence its clinical success. We aimed to investigate the effect of characteristics on FMT outcomes in C infection. In this single-centre, prospective cohort study, we included all donors who fulfilled national criteria faeces donation and delivered donations Centre Microbiota Transplantation, Aarhus University Hospital, Denmark, between...
Summary Background Excessive amounts of bile acids entering the colon due to acid malabsorption cause chronic diarrhoea. Diagnosis is possible by measuring retention fraction orally ingested 75 Selenium homotaurocholic (Se HCAT ). The knowledge long‐term effects medical treatment sparse. Aim To describe diarrhoea, adherence treatment, and quality life in a large, well‐defined cohort patients with Methods A retrospective survey was performed among 594 verified Se scans at our unit between...
As the use of fecal microbiota transplantation (FMT) has gained momentum, an increasing need for continuous access to healthy feces donors developed. Blood constitute a subset general population and may serve as appropriate group recruitment. In this study, we investigated suitability blood donors. prospective cohort recruited onsite at public Danish bank. Following their consent, underwent stepwise screening process: First, completed electronic pre-screening questionnaire rule out...
Faecal microbiota transplantation (FMT) is currently being established as a second-line treatment for recurrent Clostridium difficile infection. FMT further considered other infectious and inflammatory conditions. Safe reproducible methods donor screening, laboratory processing clinical application of are warranted.Here, we describe the development complete framework FMT. The has been developed to comply with European Tissue Act, thus considering faeces comparable human tissue not...
Summary Background Little is known about the consequences of intrauterine exposure to, and post‐natal clearance of, vedolizumab. Aims To investigate levels vedolizumab in umbilical cord blood newborns rates after birth, as well how these correlated with maternal drug levels, risk infection developmental milestones during first year life Methods Vedolizumab‐treated pregnant women inflammatory bowel disease were prospectively recruited from 12 hospitals Denmark Canada 2016‐2020. Demographics...
Abstract Purpose Clostridioides difficile infection (CDI) has a high mortality among older patients. Identification of patients with CDI in increased risk is important to target treatment and thereby reduce mortality. The aim this study was investigate rates compare frailty levels at discharge, measured by the record-based Multidimensional Prognostic Index (MPI), age severity as predictors diagnosed during hospitalisation. Methods This population-based cohort from Central Denmark Region,...
Renal transplant recipients (RTRs) are highly susceptible to infections, and antimicrobial resistance is an increasing problem with limited treatment options. Faecal microbiota transplantation (FMT) effective for recurrent Clostridium difficile infection may be used patients intestinal carriage of multidrug-resistant (MDR) microorganisms. We present a RTR who suffered from urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase-producing (ESBL+) Klebsiella pneumoniae....
Faecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infection (rCDI) and being applied experimentally in other diseases. Encapsulated administration may be equivalent efficacy to delivery through routes.A systematic review was undertaken studies using encapsulated FMT up 26 October 2020. Data on indication, clinical outcomes, safety, protocol capsule preparation were collected reported. Pooled rates rCDI calculated random-effects...