A5085704182- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
Aarhus University
2025
Aarhus University Hospital
2021-2025
Introduction Liver cirrhosis is a progressive disease with high mortality. Gut microbiota derangement, increased gut permeability, bacterial translocation and chronic inflammation all drive progression. This trial aims to investigate whether faecal transplantation (FMT) may improve the course in patients acute decompensation of liver cirrhosis. Methods analysis In this Danish, multicentre, randomised, double-blinded, placebo-controlled trial, 220 Child-Pugh score≤12 will be randomised (1:1)...
In non-alcoholic fatty liver disease (NAFLD), neutrophils in infiltrates are activated, which may contribute to progression towards steatohepatitis (NASH). However, the functional status of blood remains unknown and their role mechanisms is thus uncertain. We therefore characterized activation function patients with NAFLD relation clinical markers plasma milieu.We studied 20 NAFLD, among these 6 NASH, 14 healthy persons. Neutrophil activation, interleukin (IL)-8 production oxidative burst...