A5069763707- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Clostridium difficile and Clostridium perfringens research
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Gastrointestinal motility and disorders
- Immune cells in cancer
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Microscopic Colitis
- Organ Transplantation Techniques and Outcomes
Aarhus University
2023-2025
Aarhus University Hospital
2021-2025
Introduction Liver cirrhosis is a progressive disease with high mortality. Gut microbiota derangement, increased gut permeability, bacterial translocation and chronic inflammation all drive progression. This trial aims to investigate whether faecal transplantation (FMT) may improve the course in patients acute decompensation of liver cirrhosis. Methods analysis In this Danish, multicentre, randomised, double-blinded, placebo-controlled trial, 220 Child-Pugh score≤12 will be randomised (1:1)...
In alcoholic hepatitis (AH), translocation of gut bacteria may drive hepatic macrophage activation and systemic inflammation. We investigated the effect oral non-absorbable, broad-spectrum antibiotic treatment on bacterial liver inflammation in AH.We consecutively recruited 31 patients with AH. Fourteen were given vancomycin 500 mg, gentamycin 40 meropenem mg once daily for 7 days. Seventeen a reference group receiving standard-of-care. Circulating markers measured at baseline, by day 90....
In non-alcoholic fatty liver disease (NAFLD), neutrophils in infiltrates are activated, which may contribute to progression towards steatohepatitis (NASH). However, the functional status of blood remains unknown and their role mechanisms is thus uncertain. We therefore characterized activation function patients with NAFLD relation clinical markers plasma milieu.We studied 20 NAFLD, among these 6 NASH, 14 healthy persons. Neutrophil activation, interleukin (IL)-8 production oxidative burst...
Alcoholic hepatitis (AH) holds a high mortality, and vast macrophage infiltration of the liver is involved in progressive injury. No efficient medical treatment exists, macrophages may be future target. Here, we examine associations between non-classical monocyte subsets cell surface markers migration with disease activity patients severe AH.We analyzed samples from two cohorts AH. Cohort 1 included 15 AH patients, followed for 30 days, 8 healthy controls (HCs). 2 23 90 9 HCs. Peripheral...
This study investigated the number of blood culture-positive cattle among 215 animals clinically suspected having bacterial endocarditis. For that were necropsied, sensitivity, specificity and predictive value diagnosis endocarditis calculated on basis isolation causative bacteria from blood. Furthermore, it was whether glutaraldehyde coagulation time, total leucocyte count, per cent neutrophil granulocytes, pulse rate duration disease could help to discriminate other diseases. Among 138...
Objectives In alcoholic hepatitis (AH), dysfunctional T lymphocytes may contribute to the high mortality from infections. lymphocyte activation is governed by expression of co-stimulatory receptors such as 4-1BB balanced inhibitory Programmed Death receptor 1 (PD-1). unaccounted for in AH, while PD-1 elevated. We characterized and associated functional status AH investigated whether these were with short-term mortality. Methods Thirty-five patients (at diagnosis days 7 90) compared healthy...