A5083247553- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Pharmacogenetics and Drug Metabolism
- Biosimilars and Bioanalytical Methods
- Statistical Methods in Clinical Trials
- Lung Cancer Treatments and Mutations
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical studies and practices
- Inflammatory Bowel Disease
- Pneumonia and Respiratory Infections
- Adrenal Hormones and Disorders
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Antifungal resistance and susceptibility
- Sexual Differentiation and Disorders
- Computational Drug Discovery Methods
- Antibiotic Use and Resistance
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- Estrogen and related hormone effects
- Cancer therapeutics and mechanisms
- Microscopic Colitis
- Health Systems, Economic Evaluations, Quality of Life
- Analytical Methods in Pharmaceuticals
Freie Universität Berlin
2016-2025
University of Potsdam
2017-2025
Metropolitan University
2024
Universitat de València
2024
Universidad de Navarra
2024
Universidad Complutense de Madrid
2024
University of Puerto Rico System
2024
École des Hautes Études en Santé Publique
2022
Université de Rennes
2022
Institut de Recherche en Santé, Environnement et Travail
2022
CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into continuous kidney replacement therapy (CKRT). It primarily used in critically ill patients with sepsis and related conditions, including cytokine storms systemic inflammatory responses. Up to now, there no evidence nor recommendation the use of CS filters (22). There limited clinical data on effect plasma concentrations beta-lactams. We aimed evaluate statistical impact post-filter...
The antimicrobial agent linezolid is approved for the treatment of severe infections caused by, e.g., methicillin-resistant Staphylococcus strains. In order to evaluate penetration into interstitial space fluid (ISF) subcutaneous adipose tissue and skeletal muscle target population, a microdialysis study was performed with 12 patients sepsis or septic shock after multiple intravenous infusions. Unbound concentrations were determined plasma microdialysates by use validated high-performance...
Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success in ICU patients.To develop and externally validate population pharmacokinetic model continuous-infusion meropenem critically ill patients to establish nomogram based on routinely available marker of renal function.A was developed NONMEM® 7.3 steady-state concentrations (CSS) collected during therapeutic drug monitoring. Different serum creatinine-based markers function were compared their...
Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success critically ill patients. The objective this study was to investigate the target attainment standard meropenem dosing heterogeneous population, quantify impact full renal function spectrum on attainment, ultimately translate findings into tool for practical application.A prospective observational...
Drug approval is based on exposure, response, and variability of studied populations, typically excluding comorbidities/medications very ill patients, thus not representing real-world populations. This results in wide therapeutic outcome for individual patients. Model-informed precision dosing (MIPD) can characterize/quantify this variability, support optimal dose selection, enable individualized therapy. The aim perspective to raise awareness MIPD, identify challenges hindering its...
Abstract Background Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resistance-specific vulnerabilities, termed collateral sensitivities. Here we investigated anaplastic lymphoma kinase (ALK) inhibitor in neuroblastoma, a childhood frequently affected by activating ALK alterations. Methods Genome-wide forward genetic CRISPR-Cas9 based...
Abstract Background Therapeutic drug monitoring is effective for optimizing anti‐tumor necrosis factor therapies in inflammatory bowel disease, but vedolizumab, a gut‐selective leucocyte migration inhibitor, data are scarce. Methods Observational cohort study including 116 bio‐experienced disease patients treated with vedolizumab active luminal disease. Biobanked trough blood samples ( n = 676) covering 96% of were analyzed using drug‐binding immunofluorometric assay. Steroid‐free treatment...
Background TLD-1 is a novel liposomal doxorubicin that compared favorably to conventional formulations in preclinical models. This phase I first-in-human study aimed define the maximum tolerated dose (MTD), recommended 2 (RP2D), safety and preliminary activity of patients with advanced solid tumors. Patients methods We recruited tumors who failed standard therapy received up 3 prior lines palliative systemic chemotherapy. was administered intravenously every weeks 9 cycles (6 for...
The present study tested the ability of linezolid to penetrate soft tissues in healthy volunteers. Ten volunteers were subjected drug intake at a dose 600 mg twice day for 3 5 days. first was administered intravenously. All following doses self-administered orally. tissue penetration assessed by use vivo microdialysis. In single-dose experiments ratios area under concentration-time curve from 0 8 h (AUC0-8) AUC0-8 free plasma 1.4+/-0.3 (mean+/-standard deviation) and 1.3+/-0.4 subcutaneous...
Abstract Purpose: Cancer chemotherapy, although based on body surface area, often causes unpredictable myelosuppression, especially severe neutropenia. The aim of this study was to evaluate qualitatively and quantitatively the influence patient-specific characteristics neutrophil concentration-time course, identify patient subgroups, compare covariates system-related pharmacodynamic variable between drugs. Experimental Design: Drug concentration, demographic, clinical chemistry data several...
Few studies investigating the population pharmacokinetics of linezolid in critically ill patients have been reported, yielding controversial results. Therefore, a pharmacokinetic analysis using NONMEM was performed to thoroughly understand unbound plasma. Data were obtained from 10 healthy volunteers and 24 septic patients. Intensive sampling after single multiple dosing. The best described by two-compartment model with an absorption rate constant (<i>K</i><sub>A</sub>, 1.81 h<sup>-1</sup>),...