A5112839259- Antibiotics Pharmacokinetics and Efficacy
- Acute Kidney Injury Research
- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Hormonal and reproductive studies
- Acute Lymphoblastic Leukemia research
- Alcohol Consumption and Health Effects
- Plant nutrient uptake and metabolism
- CNS Lymphoma Diagnosis and Treatment
- Microfluidic and Capillary Electrophoresis Applications
- Legume Nitrogen Fixing Symbiosis
- Criminal Law and Policy
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Sensors
- Multiple Sclerosis Research Studies
- Neonatal Health and Biochemistry
- Blood disorders and treatments
- Antibiotic Use and Resistance
Charité - Universitätsmedizin Berlin
2020-2025
Vivantes Klinikum
2020-2025
Freie Universität Berlin
2020
Humboldt-Universität zu Berlin
2020
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2005
Jena University Hospital
2004
CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into continuous kidney replacement therapy (CKRT). It primarily used in critically ill patients with sepsis and related conditions, including cytokine storms systemic inflammatory responses. Up to now, there no evidence nor recommendation the use of CS filters (22). There limited clinical data on effect plasma concentrations beta-lactams. We aimed evaluate statistical impact post-filter...
The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of pathogen. Yet, pathogen is often unknown, antibiotic guided by empirical targets. To reliably achieve concentrations, dosing needs to be adjusted for renal function. We aimed evaluate a monitoring program intensive care unit (ICU) patients assessing (i) adequacy locally selected targets, (ii) if adequately function individual target, (iii) target attainment (TA) failure. In...
Die Analyse pflanzlicher Wirkstoffe kann bei Vergiftungen, beim Therapeutic Drug Monitoring oder der Kontrolle im Rahmen von Drogentherapien notwendig werden. Für die Diagnostik stehen sowohl Enzymimmunoassays mit kommerziell verfügbaren Testkits als auch flüssigchromatographische Messmethoden, meist Massenspektrometrie gekoppelt sind, zur Verfügung.
Eine gründliche Fallrecherche sowie die Zusammenschau von Symptomatik und klinisch-chemischen Parametern bilden bei der Aufklärung Intoxikationsverdachtsfällen Basis für Auswahl optimalen, individuellen Analysestrategie haben einen entscheidenden Einfluss auf Bearbeitungsdauer Aussagekraft Untersuchungen. Das breite Spektrum an toxisch wirksamen Substanzen bedarf verschiedener Analysesysteme Kenntnis analytischen Grenzen zu deren Nachweis. Vor allem toxikologische Screenings erfordern...
Abstract Background Accurate assessment of kidney function is needed for a variety clinical indications and research. The measurement the serum clearance iohexol has emerged as feasible method to reach this objective. We report analytical validation application new high-performance liquid chromatography (HPLC) – tandem mass spectrometry (MS/MS) assay quantify in human serum. Specificity was enhanced due use specific acceptance limits relative ion (RI) intensities. Methods internal standard...