A5103246356- Antibiotics Pharmacokinetics and Efficacy
- Acute Kidney Injury Research
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Blood disorders and treatments
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
Freie Universität Berlin
2022-2025
University of Potsdam
2022-2025
CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into continuous kidney replacement therapy (CKRT). It primarily used in critically ill patients with sepsis and related conditions, including cytokine storms systemic inflammatory responses. Up to now, there no evidence nor recommendation the use of CS filters (22). There limited clinical data on effect plasma concentrations beta-lactams. We aimed evaluate statistical impact post-filter...
The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of pathogen. Yet, pathogen is often unknown, antibiotic guided by empirical targets. To reliably achieve concentrations, dosing needs to be adjusted for renal function. We aimed evaluate a monitoring program intensive care unit (ICU) patients assessing (i) adequacy locally selected targets, (ii) if adequately function individual target, (iii) target attainment (TA) failure. In...
Background: A novel fixed combination of aztreonam (ATM) and avibactam (AVI) offers promising potential to treat infections with carbapenem-resistant Enterobacterales (CRE) producing metallo-β-lactamases (MBL). This study aimed assess the accuracy population pharmacokinetic (PK) models for ATM-AVI in predicting vivo concentrations a critically ill patient CRE infection during its first clinical use. Methods: 70-year-old male septic shock due hospital-acquired pneumonia (HAP) caused by...