A5009209268- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Receptor Mechanisms and Signaling
- Antibiotic Resistance in Bacteria
- Innovative Microfluidic and Catalytic Techniques Innovation
- Renal function and acid-base balance
- 3D Printing in Biomedical Research
- Pharmacogenetics and Drug Metabolism
- Cardiac electrophysiology and arrhythmias
- Computational Drug Discovery Methods
- Microfluidic and Capillary Electrophoresis Applications
- Hemodynamic Monitoring and Therapy
Freie Universität Berlin
2021-2025
Boehringer Ingelheim (Germany)
2024
University of Potsdam
2021-2022
Microphysiological systems (MPSs) are promising in vitro technologies for physiologically relevant predictions of the human absorption, distribution, metabolism, and excretion (ADME) properties drug candidates. However, polydimethylsiloxane (PDMS), a common material used MPSs, can both adsorb absorb small molecules, thereby compromising experimental results. This study aimed to evaluate feasibility using PDMS-based Emulate gut-on-chip determine first-pass intestinal clearance. In cell-free...
Abstract Background Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb ® unintentionally adsorbs vancomycin. This study aimed to quantify vancomycin elimination by . Methods Critically shock receiving continuous renal replacement therapy and treatment during a prospective observational were included analysis. Vancomycin pharmacokinetics was characterized using population pharmacokinetic...
The ICH E14/S7B Q&As highlighted the need for best practices concerning design, execution, analysis, interpretation, and reporting of in vivo non‐rodent QT assay as a component integrated risk assessment to potentially support TQT waiver or substitute. We conducted dog telemetry study assess effects on QTc six reference compounds (five positive one negative) previously evaluated by Darpo et al. (2015) humans. sensitivity detect increases was determined, exposure–response analysis...
The altered pharmacokinetics of renally cleared drugs such as meropenem in critically ill patients receiving continuous renal replacement therapy (CRRT) might impact target attainment. Model-informed precision dosing (MIPD) is applied to individualize dosing. However, most population pharmacokinetic (PopPK) models developed date have not yet been evaluated for MIPD. Eight PopPK based on adult CRRT were identified a systematic literature research and encoded NONMEM 7.4. A data set 73 from two...
Pneumonia is one of the most common infections in intensive care patients, and it often treated with beta-lactam antibiotics. Even if therapeutic drug monitoring blood available, unclear whether sufficient concentrations are reached at target site: lung. The present study was initiated to fill this knowledge gap. Various compartments from 10 patients' explanted lungs were subjected laboratory analysis. Meropenem quantified serum, bronchoalveolar lavage (BAL) fluid, microdialysate,...
Meropenem is one of the most frequently used antibiotics to treat life-threatening infections in critically ill patients. This study aimed develop a meropenem dosing algorithm for treatment Gram-negative based on intensive care unit (ICU)-specific resistance data. Antimicrobial susceptibility testing bacteria obtained from patients was carried out 2016 2020 at tertiary hospital. Based observed MIC distribution, stochastic simulations (n = 1,000) an evaluated pharmacokinetic model, and...
The MeroRisk-calculator, an easy-to-use tool to determine the risk of meropenem target non-attainment after standard dosing (1000 mg; q8h), uses a patient's creatinine clearance and minimum inhibitory concentration (MIC) pathogen. In clinical practice, however, MIC is rarely available. objectives were evaluate MeroRisk-calculator extend assessment by including general pathogen sensitivity data. Using routine dataset (155 patients, 891 samples), direct data-based evaluation was not feasible....
The indole alkaloid yohimbine is an alpha-2 receptor antagonist used for its sympathomimetic effects. Several cases of intoxication have been reported and the most recent one involved four individuals taking a yohimbine-containing drug powder. All developed severe symptoms were admitted to hospital. Even though all assumed taken same dose powder, toxicology analyses revealed blood concentrations 249-5631 ng/mL, amounting 22-fold difference. reason this high variability remained be...
The prevalence and mortality rates of severe infections are high in intensive care units (ICUs). At the same time, pharmacokinetic variability observed ICU patients increases risk inadequate antibiotic drug exposure. Therefore, dosing tailored to specific patient characteristics has a potential improve outcomes this vulnerable population. This study aimed develop tabular decision tool for initial therapy meropenem integrating hospital-specific, thus far unexploited pathogen susceptibility...
The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of pathogen. Yet, pathogen is often unknown, antibiotic guided by empirical targets. To reliably achieve concentrations, dosing needs to be adjusted for renal function. We aimed evaluate a monitoring program intensive care unit (ICU) patients assessing (i) adequacy locally selected targets, (ii) if adequately function individual target, (iii) target attainment (TA) failure. In...