A5055240681- Inflammatory Bowel Disease
- Vitamin D Research Studies
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- COVID-19 and healthcare impacts
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Spondyloarthritis Studies and Treatments
- Bone health and osteoporosis research
- Gut microbiota and health
- Nutrition, Genetics, and Disease
- Bone health and treatments
- Global Cancer Incidence and Screening
- Appendicitis Diagnosis and Management
- Psoriasis: Treatment and Pathogenesis
- Economic and Financial Impacts of Cancer
- Rheumatoid Arthritis Research and Therapies
- Helicobacter pylori-related gastroenterology studies
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Multiple Myeloma Research and Treatments
Regionshospitalet Silkeborg
2012-2024
Aarhus University
1997-2022
Lillebaelt Hospital
2022
Aarhus University Hospital
1995-2016
University of Copenhagen
2007
Lund University
2007
Bandim Health Project
2007
Aarhus Municipality
2004
Regional Hospital Horsens
1994
Sunlight exposure of the skin is known to be most important source vitamin D. The aims this study were: (i) estimate D status amongst sunlight-deprived individuals (veiled Arab women, veiled ethnic Danish Moslem women and controls); (ii) through food intake analysis oral necessary keep a normal in individuals.Cross-sectional randomly selected origin living Denmark. Age-matched were included as controls. To control for racial differences, group (all Caucasians) was included.Primary Health...
Vitamin D has been shown to be involved in the host immune response toward Mycobacterium tuberculosis.To test whether vitamin supplementation of patients with tuberculosis (TB) improved clinical outcome and reduced mortality.We conducted a randomized, double-blind, placebo-controlled trial TB clinics at demographic surveillance site Guinea-Bissau. We included 365 adult starting antituberculosis treatment; 281 completed 12-month follow-up. The intervention was 100,000 IU cholecalciferol or...
Vitamin D has immune-regulatory functions in experimental colitis, and low vitamin levels are present Crohn's disease.To assess the effectiveness of D3 treatment disease with regard to improved course.We performed a randomized double-blind placebo-controlled trial benefits oral disease. We included 108 patients remission, which fourteen were excluded later. Patients receive either 1200 IU (n = 46) or placebo 48) once daily during 12 months. The primary endpoint was clinical relapse.Oral...
BackgroundThe etiology of the inflammatory bowel diseases, including ulcerative colitis (UC), remains incompletely explained. We hypothesized that an analysis UC colon proteome could reveal novel insights into disease etiology.
Increased small intestinal wall thickness correlates with both inflammatory activity and fibrosis in Crohn’s disease [CD]. Assessment of perfusion holds promise as an objective marker distinguishing between the two conditions. Our primary aim was to determine if relative bowel measurements correlate histopathological scores for inflammation or CD. A total 25 patients were investigated before elective surgery Unenhanced ultrasonography [US] magnetic resonance enterography [MRE] applied...
Evidence on ustekinumab safety in pregnancy is gradually expanding, but its clearance the postnatal period unknown. The aim of this study was to investigate concentrations umbilical cord blood and rates after birth, as well how these correlate with maternal drug concentrations, risk infection, developmental milestones during first year life.
We aimed at studying fracture risk in patients with Duchenne's muscular dystrophy (DMD), Becker's (BEMD), and spinal atrophy type II III (SMA III). A self-administered questionnaire was mailed to 293 DMD, BEMD, SMA or of which 229 returned the questionnaire. Each respondent compared an age- gender-matched control subject. The mean age 23.9 +/- 15.9 years for 23.3 16.5 controls. There were significantly more fractures among than controls after diagnosis made (RR = 1.9), but not before. had...
Saccharomyces cerevisiae, known as baker's yeast, is normally considered a non-pathogenic yeast. A genetically very similar subtype, S boulardii, used in probioticum (Sacchaflor) to prevent antibiotic-associated diarrhoea and the treatment of recurrent Clostridium difficile associated diarrhoea. The authors present case report 79-year-old woman with rheumatoid arthritis, who after bowel resection developed boulardii fungemia. Her postoperative course was complicated by nutritional problems,...
Rheumatoid arthritis (RA) is an inflammatory joint disease leading to cartilage damage and ultimately impaired function. To gain new insight into the systemic immune manifestations of RA, we characterized colon mucosa proteome from 11 RA-patients 10 healthy controls. The biopsies were extracted by colonoscopy analyzed label-free quantitative proteomics, enabling quantitation 5366 proteins. abundance dihydrofolate reductase (DHFR) was statistically significantly increased in RA-patient...
An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial faecal transplantation (FMT) infused into small intestine patients with PsA active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is explore clinical aspects associated FMT performed PsA.This a two-centre stratified, double-blind (patient, care provider and outcome...
Abstract: In order to evaluate the use of recently developed assays bone metabolism in multiple myeloma we performed a histomorphometric study biopsies 16 patients. Furthermore, measured levels interleukin‐6 (IL‐6), soluble IL‐6 receptor (IL‐6sR), IL‐1β, tumour necrosis factor (TNF) α, TNFβ, and transforming growth (TGF) β marrow plasma aspirated from biopsy area. Markers resorption : The N ‐terminal telopeptide collagen I (Ntx) urine showed strong positive correlation with dynamic indices (...
Survivor analysis of total hip replacement recently has shown disappointing results in younger patients. To improve this, ceramic coatings have been applied to prostheses for cementless use. A new fluorine containing coating, fluorapatite, increase bone ingrowth compared with hydroxyapatite unloaded models. In a weight loaded model, the effects and fluorapatite coated implants on implant fixation were evaluated. Eight porous surface inserted into medial femoral condyles 8 mature dogs paired...
INTRODUCTION: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity fibrosis burden in Crohn's disease (CD). This study aimed to verify the association MRE metrics with histologic independent inflammation. METHODS: prospective European multicenter performed on 60 patients CD strictures before surgical resection. Locations 61 histological samples were annotated examinations, followed by central readings...
Objective: Intestinal inflammation is frequent in patients with spondyloarthritis (SpA). Here, we test the validity of faecal calprotectin as a marker intestinal SpA and evaluate response adalimumab without lesions.Method: Patients were included on basis active Bath Ankylosing Spondylitis Disease Activity Index ≥ 4. After 4 week non-steroidal anti-inflammatory drug washout period, divided into two groups based level (> 100 mg/kg, n = 15, < 50 15). Adalimumab 40 mg every other was initiated....
Abstract: This study was performed as a cross‐sectional substudy to the Danish–Swedish Pamidronate Study, randomized placebo‐controlled multicentre trial in multiple myeloma. The purpose evaluate biological effects of long‐term treatment with oral pamidronate 300 mg daily on bone metabolism by using histomorphometry and analysis cytokines biochemical markers turnover. Sixteen patients were included after median 27.5 months protocolized treatment; 10 received active 6 placebo. When compared...
A better understanding of the clinical relevance delayed gastric emptying (e.g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two "new" methods liquids (the paracetamol absorption test 13C-acetate breath test) are compared with gold standard (gastric scintigraphy (GES)).The three techniques were used simultaneously 10 healthy subjects. time-retention curve was drawn each technique results at 75%, 50% 25% retention quartiles.Agreement found between...
Chronic inflammatory diseases (CIDs), including Crohn’s disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic spondyloarthritides, hidradenitis suppurativa, immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of patients do not respond to treatment. Genetics lifestyle may affect treatment results. The aims this...
Introduction Chronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in aetiology of these diseases. Up to one-third patients do not, however, respond biologics, and lifestyle factors assumed affect treatment outcomes. Little is known about effects dietary as a prognostic that may enable personalised...