A5004522580- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Cardiac, Anesthesia and Surgical Outcomes
- Osteoarthritis Treatment and Mechanisms
- Dental Implant Techniques and Outcomes
- Bone fractures and treatments
- Anesthesia and Pain Management
- Bone health and osteoporosis research
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Pelvic and Acetabular Injuries
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Advanced X-ray and CT Imaging
- Musculoskeletal Disorders and Rehabilitation
- Knee injuries and reconstruction techniques
- Surgical site infection prevention
- Advanced materials and composites
- Cardiac Valve Diseases and Treatments
Odense University Hospital
2016-2025
University of Southern Denmark
2016-2025
Copenhagen University Hospital
2014-2025
University of Copenhagen
2012-2025
Bispebjerg Hospital
1996-2025
Frederiksberg Hospital
2014-2025
Rigshospitalet
2024
Collaborative Group (United States)
2023
ACTA (United States)
2023
Aalborg University
2018-2023
Background . Scaffolds for bone tissue engineering (BTE) can be loaded with stem and progenitor cells (SPC) from different sources to improve osteogenesis. SPC found in marrow, adipose tissue, other tissues. Little is known about osteogenic potential of adipose‐derived culture expanded, adherent (A‐CEAC). This study compares vivo capacity between A‐CEAC marrow derived (BM‐CEAC). Method BM‐CEAC were isolated five female sheep seeded on hydroxyapatite granules prior subcutaneous implantation...
Abstract In patients with prior hip fracture (HFx), little is known about time frame and risk factors of second HFx, as well the ensuing mortality. The aim study was to elucidate incidence HFx subsequent All 169,145 a first in Denmark during 1977–2001 were followed for up 25 yr compared background population. Data on fractures, vital status, comorbidity, redeemed prescriptions, socio-demographic variables retrieved from national registers. Median follow-up 3.8 yr, corresponding 1,041,177...
The risk of revision due to infection after primary total hip arthroplasty (THA) has been reported be increasing in Norway. We investigated whether this increase is a common feature the Nordic countries (Denmark, Finland, Norway, and Sweden).The study was based on Arthroplasty Register Association (NARA) dataset. 432,168 THAs from 1995 2009 were included (Denmark: 83,853, Finland 78,106, Norway 88,455, Sweden 181,754). Adjusted survival analyses performed using Cox regression models with as...
Background: We used the Nordic Arthroplasty Register Association database to evaluate whether age, sex, preoperative diagnosis, fixation, and implant design influence risk of revision arthroplasty due periprosthetic fracture within two years from operation a primary total hip replacement. Methods: Included in study were 325,730 cemented femoral stems 111,899 uncemented inserted 1995 2009. Seven frequently (two [Exeter Lubinus SP II] five [Bi-Metric, Corail, CLS Spotorno, ABG I, II])...
Revision for prosthetic joint infection (PJI) has a major effect on patients' health but it remains unclear if early PJI after primary THA is associated with high mortality.(1) Do patients revision within 1 year of have increased mortality compared who do not undergo any reason THA? (2) an risk aseptic revision? (3) Are there particular bacteria among that are death?This population-based cohort study was based the longitudinally maintained Danish Hip Arthroplasty Register performed in...
Abstract Objective To investigate the effects of one and two doses intravenous dexamethasone in patients after total knee arthroplasty. Design Randomised, blinded, placebo controlled trial with follow-up at 90 days. Setting Five Danish hospitals, September 2018 to March 2020. Participants 485 adult participants undergoing Intervention A computer generated randomised sequence stratified for site was used allocate three groups: DX1 (dexamethasone (24 mg)+placebo); DX2 mg)+dexamethasone mg));...
Background and purpose The possibility of comparing results pooling the data has been limited for Nordic arthroplasty registries, because different registration systems questionnaires. We have established a common database, in order to compare demographics total hip replacement surgery between countries. In addition, we plan study patient groups which numbers are too small be studied individual countries.Material methods Primary replacements (THRs) from 1995–2006 were selected study....
<b>Objective </b>To assess the failure rate of cemented, uncemented, hybrid, and reverse hybrid total hip replacements in patients aged 55 years or older. <b>Design</b> Register study. <b>Setting</b> Nordic Arthroplasty Association database (combined data from Sweden, Norway, Denmark, Finland). <b>Participants</b> 347 899 performed during 1995-2011. <b>Main outcome measures</b> Probability implant survival (Kaplan-Meier analysis) along with revision for any reason as endpoint (Cox multiple...
Background and purpose — The increased use of patient-reported outcomes (PROs) in orthopedics requires data on estimated minimal clinically important improvements (MCIIs) patient-acceptable symptom states (PASSs). We wanted to find cut-points corresponding PRO change score the acceptable postoperative score, by estimating MCII PASS 1 year after total hip arthroplasty (THA) for Hip Dysfunction Osteoarthritis Outcome Score (HOOS) EQ-5D.Patients methods THA patients from 16 different...
Background and purpose — It has been suggested that the risk of prosthetic joint infection (PJI) in patients with total hip arthroplasty (THA) may be underestimated if based only on registry data. We therefore wanted to estimate "true" incidence PJI THA using several data sources. Patients methods searched Danish Hip Arthroplasty Register (DHR) for primary THAs performed between 2005 2011. Using DHR National (NRP), we identified first revisions any reason those were due PJI. PJIs also an...
There has been a limited amount of research on risk factors for revision due to infection following total hip arthroplasty (THA), probably low absolute numbers revisions. We therefore studied patient- and surgery-related after primary THA in population-based setting.Using the Danish Hip Arthroplasty Registry, we identified 80,756 THAs performed Denmark between Jan 1, 1995 Dec 31, 2008. used Cox regression analysis compute crude adjusted relative (RR) infection. Revision was defined as...
Background: Data on the risk factors for venous thromboembolism among patients undergoing total hip replacement and receiving pharmacological thromboprophylaxis are limited. The purpose of this study was to examine potential patient-related following in a nationwide follow-up study. Methods: Using medical databases, we identified all who underwent primary received Denmark from 1995 2006. outcome measure hospitalization with within ninety days surgery. We considered age, sex, indication...
<h3>Importance</h3> Multimodal postoperative analgesia is widely used but lacks evidence of benefit. <h3>Objective</h3> Investigate beneficial and harmful effects 4 nonopioid analgesics regimens. <h3>Design, Setting, Participants</h3> Randomized, blinded, placebo-controlled, 4-group trial in 6 Danish hospitals with 90-day follow-up that included 556 patients undergoing total hip arthroplasty (THA) from December 2015 to October 2017. Final date was January 1, 2018. <h3>Interventions</h3>...
To investigate predictors of 10-year risk revision and 1-year prosthetic joint infection (PJI) death following total hip/total knee arthroplasty (THA/TKA) in (1) patients with rheumatoid arthritis (RA) compared osteoarthritis (OA); (2) RA treated biological disease-modifying antirheumatic drugs (bDMARD) within 90 days preceding surgery non-treated.Register-based cohort study using the Danish National Patient Register, DANBIO rheumatology register (RA-specific confounders treatment episodes)...
We examined the risk of thrombotic and major bleeding events in patients undergoing total hip knee replacement (THR TKR) treated with thromboprophylaxis, using nationwide population-based databases. identified 83 756 primary procedures performed between 1997 2011. The outcomes were symptomatic venous thromboembolism (VTE), myocardial infarction (MI), stroke, death requiring hospitalisation within 90 days surgery. A 1114 (1.3%) 483 (0.6%) experienced VTE bleeding, respectively. annual varied...
Background and purpose An earlier Nordic Arthroplasty Register Association (NARA) report on 280,201 total hip replacements (THRs) based data from 1995–2006, Sweden, Norway, Denmark, was published in 2009. The present study assessed THR survival according to country, the NARA database with Finnish included. Material methods 438,733 THRs performed during period 1995–2011 Finland were Kaplan-Meier analysis used calculate probabilities 95% confidence interval (CI). Cox multiple regression,...
Background: The dual-mobility acetabular cup (DMC) has an additional bearing consisting of a mobile polyethylene component between the prosthetic head and outer metal shell. This design gained popularity in revision total hip arthroplasty (THA) primary treatment femoral neck fractures with anticipation reduced risk THA instability. Our aim was to evaluate overall these cups on basis data from Nordic Arthroplasty Register Association (NARA) database, our secondary study specific causes...
the results of their research on human subjects and are accountable for completeness accuracy reports."Protocols should be considered mandatory before initiating any project; to help enforce this principle, prespecified protocols also available upon request.Planning study properly requires that authors have already consulted reporting guidelines when planning a project (https://www.equator-network.org/).Various been developed different designs.Famous examples these include STROBE RECORD...
We recorded inter- and intra-observer variations in the classification of ankle fractures by Lauge Hansen Weber systems. Radiographs 94 patients were classified independently four observers. The observer variation was calculated kappa statistics, which corrects obtained values for agreement expected chance. There an acceptable level overall into both For staging supination-adduction supination-eversion system poor. results indicate that future systems should be subject to reliability...
There are few publications regarding the validity of data in hip arthroplasty registers. The Danish Hip Arthroplasty Registry (DHR) is a nationwide clinical database THAs and revisions Denmark.We assessed completeness registration primary total arthroplasties (THAs) DHR from 1995-2000. In addition, positive predictive value (PPV) registered for diagnoses patients undergoing THA postoperative complications was analyzed. Completeness using National Patients (NRP) as reference, which...