A5070980567- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Gut microbiota and health
- Microscopic Colitis
- Osteoarthritis Treatment and Mechanisms
- COVID-19 and Mental Health
- Biosimilars and Bioanalytical Methods
- Clostridium difficile and Clostridium perfringens research
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Healthcare professionals’ stress and burnout
- Pharmacological Effects of Natural Compounds
- Biomedical Ethics and Regulation
- Pharmaceutical studies and practices
- Pediatric health and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Telemedicine and Telehealth Implementation
- Vaccine Coverage and Hesitancy
- Pharmaceutical Economics and Policy
- Peripheral Neuropathies and Disorders
Odense University Hospital
2013-2024
Rigshospitalet
2023-2024
Center for Rheumatology
2021-2024
University of Southern Denmark
2014-2024
Glostrup Hospital
2024
Hammersmith Hospital
2023
Imperial College London
2023
Imperial College Healthcare NHS Trust
2023
National Health Service
2023
St. Mary's Hospital
2023
Objectives Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated safety and efficacy FMT in psoriatic arthritis (PsA). Methods double-blind, parallel-group, placebo-controlled, superiority trial, randomly allocated (1:1) adults with active peripheral PsA (≥3 swollen joints) despite ongoing...
In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence disease-modifying antirheumatic treatment (DMARD) during the initial phase of COVID-19 pandemic again after reopening society started. Furthermore, identify characteristics high levels anxiety self-isolation.Patients in routine care followed prospectively nationwide DANBIO registry were invited answer an online questionnaire regarding disease activity...
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
Objectives The gut microbiota can mediate both pro and anti-inflammatory responses. In patients with psoriatic arthritis (PsA), we investigated the impact of faecal transplantation (FMT), relative to sham transplantation, on 92 inflammation-associated plasma proteins. Methods This study relates FLORA trial cohort, where 31 moderate-to-high peripheral PsA disease activity, despite at least 3 months methotrexate treatment, were included in a 26-week, double-blind, randomised, sham-controlled...
An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial faecal transplantation (FMT) infused into small intestine patients with PsA active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is explore clinical aspects associated FMT performed PsA.This a two-centre stratified, double-blind (patient, care provider and outcome...
In 2018, a nationwide mandatory switch from originator to biosimilar adalimumab was conducted in Denmark. The available GP2017 (Hyrimoz) Eastern regions and SB5 (Imraldi) Western regions. We aimed assess the comparative effectiveness of versus patients with rheumatoid arthritis (RA)/psoriatic (PsA)/axial spondyloarthritis (AxSpA).Observational cohort study based on DANBIO registry geographical cluster pseudo-randomisation, analysed by emulating randomised clinical trial. Main outcome...
Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both characterized by altered extracellular matrix remodeling in joints entheses that results destructive osteochondral proliferative lesions. There is a need for biomarkers reflecting core disease pathways diagnosis mapping. Pro-C2 reflects mature cartilage collagen type IIB formation, while C-Col10 represents turnover of X collagen, which exclusively expressed...
Chronic inflammatory diseases (CIDs) pose a growing healthcare challenge, with substantial proportion of patients showing inadequate response to biological treatment. There is renewed interest in dietary changes optimize treatment regimens, body evidence suggesting beneficial effects adherence gluten-free diet. This study compared the likelihood achieving clinical after 14-16 weeks CID high versus low-to-medium gluten intake. Secondary outcomes included disease activity, health-related...
Introduction Chronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in aetiology of these diseases. Up to one-third patients do not, however, respond biologics, and lifestyle factors assumed affect treatment outcomes. Little is known about effects dietary as a prognostic that may enable personalised...
Background Biologic disease-modifying drugs have revolutionised the treatment of a number chronic inflammatory diseases (CID). However, up to 60% patients do not sufficient response and there is need for optimization strategies. Objective To investigate if outcome biological therapy associated with habitual dietary intake fibre red/processed meat in CID. Methods In this multicentre prospective cohort study, we consecutively enrolled 233 adult diagnosis Crohn's Disease, Ulcerative Colitis,...
We investigated intestinal permeability and fecal, plasma, urine metabolomic profiles in methotrexate-treated active psoriatic arthritis (PsA) how this related to clinical response following one sham or fecal microbiota transplantation (FMT).This exploratory study is based on the FLORA trial cohort, which 31 patients with moderate-to-high peripheral PsA disease activity, despite at least 3 months of methotrexate-treatment, were included a 26-week, double-blind, 1:1 randomized,...
Patients' first-hand experiences of faecal microbiota transplantation (FMT) performed in a rheumatological care setting have yet to be elucidated. The objectives were explore participants' perceptions being part an FMT trial thereby identifying potential participation effects and enlightening the patient perspective on outlook for future trials rheumatic diseases.In qualitative study nested within double-blind, randomised, placebo-controlled (RCT) testing as new antirheumatic treatment,...
Objective Successful uptake of biosimilars in rheumatology is limited by lack real-world evidence regarding effectiveness biosimilar-to-biosimilar switching. We investigated infliximab CT-P13-to-GP1111 switching among patients with rheumatoid arthritis (RA), psoriatic (PsA) and axial spondyloarthritis (AxSpA). Methods Observational cohort study from the DANBIO registry. Patients were classified as originator-naïve or originator-experienced. Retention rates 1-year GP1111 treatment explored...
Abstract Background Currently, there are no reliable biomarkers for predicting treatment response in chronic inflammatory diseases (CIDs). Objective To determine whether serum microfibrillar-associated protein 4 (MFAP4) levels can predict the to biological therapy patients with CIDs. Methods The BELIEVE study was originally designed as a prospective, multi-center cohort of 233 either rheumatoid arthritis, psoriatic psoriasis, axial spondyloarthritis, Crohn’s disease, or ulcerative colitis,...
Background: The COVID-19 pandemic has caused lockdown, reduced access to face-to-face consultations, anxiety about taking immunosuppressive agents and self-isolation 1 which potentially impact rheumatic disease control negatively. However, changes in behavior including self-protection strategies during the ongoing on activity have only been scarcely described. first wave hit Denmark March 2020 followed by a gradual re-opening from mid-April second surge began late autumn of 2020. Objectives:...
To explore the impact of COVID-19 pandemic on treat-to-target strategies (disease activity, remission rates) and access to physical consultations in patients with inflammatory rheumatic disease, as well characteristics with/without clinic early vs established disease.
Introduction Pulmonary diseases are significant contributors to morbidity and mortality in patients with rheumatoid arthritis (RA). RA-associated interstitial lung disease (RA-ILD) may be prevalent up 30% clinically evident 10% of RA. Feasible methods detect concomitant ILD RA warranted. Our objective is determine the diagnostic accuracy thoracic ultrasound (TUS) for respiratory symptoms, by using chest high-resolution CT (HRCT) as reference standard. Further, we aim evaluate promising blood...
Objectives: To investigate whether antibody response patterns against Klebsiella pneumoniae capsular serotypes can discriminate patients with axial spondyloarthritis (axSpA) from non-specific low back pain (LBP).Method: Immunoglobulin (Ig)G and IgA antibodies K. K2, K26, K36, K50 were measured, seropositivity compared between groups analysed for patient correlation in five different groups: (a) 96 fulfilling the Assessment of SpondyloArthritis International Society (ASAS) classification...
Infections especially in women, patients receiving biological treatments, those with comorbidities and poor QoL.In the light of ongoing pandemic future waves, continuous awareness difficult balance between social distancing work obligations is important.
Surfactant protein-D (SP-D), an innate immune defence molecule of the collectin family, is expressed in lungs and additional extrapulmonary epithelia. SP-D has modulatory anti-microbial effects depending on its oligomerization. The ratio high molecular weight (HMW): low (LMW) serum mainly determined by Met11Thr polymorphism (SNP rs721917). We aimed to study level size distribution patients with untreated axial spondyloarthritis (axSpA) as compared control subjects.Thirty-four disease...
Objective To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus 2019 (COVID-19) pandemic, including attitudes toward effects of SARS-CoV-2 vaccination. Methods A nationwide online survey was conducted at 3 timepoints: May 2020, November 2021. Patients IRD followed Danish Rheumatology Quality Registry (DANBIO) were asked about infection their behavior, anxiety, concerns. The 2021 included influenza Characteristics associated...
Aims In May 2020, a nationwide, web-based system for remote entry of patient-reported outcomes (PROs) in inflammatory rheumatic diseases was launched and implemented routine care (DANBIO-from-home). After 1.5 years use, we explored clinical characteristics patients who did versus not use the system, time to first PROs. Methods All followed DANBIO were informed about DANBIO-from-home by electronic invitations or when attending their clinic. Characteristics did/did period after implementation...
Abstract The prevalence and disease burden of chronic inflammatory diseases (CIDs) are predicted to rise. Patients commonly treated with biological agents, but the individual treatment responses vary, warranting further research into optimizing strategies. This study aimed compare clinical in patients CIDs initiating biologic therapy based on smoking status, a notorious risk factor CIDs. In this multicentre cohort including 233 diagnosis Crohn's disease, ulcerative colitis, rheumatoid...