Gudrun Rutsdottir
A5067512879- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- Tuberculosis Research and Epidemiology
- Language and cultural evolution
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Chronic Lymphocytic Leukemia Research
deCODE Genetics (Iceland)
2020-2024
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
The genetic basis of the human vocal system is largely unknown, as are sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity genome with vowel acoustics speech recordings from 12,901 Icelanders. We show how pitch vary across life span correlate anthropometric, physiological, cognitive traits. found have a heritable component discovered correlated common ABCC9 associate pitch. also adrenal gene expression cardiovascular By showing...
Abstract Autoimmune thyroid disease (AITD) is a common autoimmune disease. In GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 previously unreported. Multiomics analysis yields 235 candidate genes outside the MHC-region findings highlight importance involved in T-cell regulation. A rare 5’-UTR variant (rs781745126-T, MAF = 0.13% Iceland) LAG3 has largest effect (OR 3.42, P 2.2 × 10 −16 ) generates...