Kristbjörg Gunnarsdóttir
A5085755320- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Advanced Proteomics Techniques and Applications
- COVID-19 and Mental Health
- Genetic factors in colorectal cancer
- Olfactory and Sensory Function Studies
- Periodontal Regeneration and Treatments
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Law, AI, and Intellectual Property
- Music Therapy and Health
- Knee injuries and reconstruction techniques
- Bioinformatics and Genomic Networks
- Genetics, Bioinformatics, and Biomedical Research
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Tuberculosis Research and Epidemiology
- Xenotransplantation and immune response
- Tissue Engineering and Regenerative Medicine
deCODE Genetics (Iceland)
2019-2024
Amgen (Canada)
2022
Directorate of Health
2020
University of Iceland
2020
National University Hospital of Iceland
2020
Little is known about the nature and durability of humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).We measured antibodies in serum samples from 30,576 persons Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), we determined that appropriate measure seropositivity was a positive result both pan-Ig assays. We tested 2102 collected 1237 up 4 months after diagnosis by quantitative polymerase-chain-reaction (qPCR)...
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
Abstract Bone area is one measure of bone size that easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study DXA the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci replicate in samples European East Asian descent ( N = 13,608 – 21,277). Eight associate with osteoarthritis, including rs143384 GDF5 missense variant COL11A1 (rs3753841). The strongest rs11614913[T] microRNA MIR196A2 gene associates P 2.3 × 10 −42 , β...
Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers OA that could predict disease occurrence and/or joint replacement. Methods Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, whom 12,178 individuals had 2,524 undergone We performed a case–control identification potential protein hip, knee, hand OA, prospective Results Among large panel assessed, cartilage...
Abstract Thousands of non-coding variants have been associated with increased risk human diseases, yet the causal and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel reporter assays (MPRA), expression analyses (eQTL, meQTL, PCHiC) chromatin accessibility in primary cells (caQTL), we investigate 1,039 multiple myeloma (MM). We demonstrate that MM susceptibility is mediated by gene-regulatory changes plasma B-cells, identify putative at six loci...
Background: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene ( LDLR ) cause elevated levels of cholesterol and premature cardiovascular disease. To date, a gain-of-function mutation with large effect on has not been described. Here, we searched for sequence variants that have levels. Methods: We analyzed whole-genome sequencing data from 43 202 Icelanders. Single-nucleotide polymorphisms structural including deletions, insertions, duplications were genotyped...
Abstract Memory T-cell responses following SARS-CoV-2 infection have been extensively investigated but many studies small with a limited range of disease severity. Here we analyze reactive in 768 convalescent SARS-CoV-2-infected (cases) and 500 uninfected (controls) Icelanders. The are stable three to eight months after infection, irrespective severity even those the mildest symptoms induce broad persistent responses. Robust CD4 + detected against all measured proteins (M, N, S S1) while N...
Abstract Autoimmune thyroid disease (AITD) is a common autoimmune disease. In GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 previously unreported. Multiomics analysis yields 235 candidate genes outside the MHC-region findings highlight importance involved in T-cell regulation. A rare 5’-UTR variant (rs781745126-T, MAF = 0.13% Iceland) LAG3 has largest effect (OR 3.42, P 2.2 × 10 −16 ) generates...
By the end of July 2021, majority Icelandic population had received vaccination against COVID-19. In mid-July a wave SARS-CoV-2 infections, dominated by Delta variant, spread through population, followed an Omicron in December. A booster campaign was initiated to curb virus. We estimate risk infection for different vaccine combinations using data from 276,028 persons and 963,557 qPCR tests 277,687 persons. measure anti-Spike-RBD antibody levels ACE2-Spike binding inhibitory activity 371 who...
Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear.We invited all 3098 adults who tested positive in Iceland before October 2020 to the deCODE Health Study. We compared multiple and physical between 1706 Icelanders confirmed prior (cases) participated, 619 contemporary 13,779 historical controls. Cases participated study 5-18 months infection.Here we report that 41 of 88 associated infection, most significantly disturbed smell taste,...
Abstract By the end of July 2021, majority Icelandic population had received vaccination against COVID-19. In mid-July a wave SARS-CoV-2 infections, dominated by delta variant, spread through population, followed an omicron in December. A booster campaign was initiated to curb virus. We estimated risk infection for different vaccine combinations using data from 276,028 persons and 963,557 qPCR tests 277,687 persons. measured anti-Spike-RBD antibody levels ACE2-Spike binding inhibitory...
Human embryonic stem cell-derived mesenchymal progenitor (hES-MP) cells are mesenchymal-like cells, derived from human without the aid of feeder cells. They have been suggested as a potential alternative to stromal (MSCs) in regenerative medicine due their proliferation and differentiation characteristics. Cells cell products intended for humans should be derived, expanded differentiated using conditions free animal-derived minimize risk animal-transmitted disease immune reactions foreign...
The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in blood. As some these are strongly correlated, it important evaluate independent effects they may have on survival.Tumour samples from 2162 CRC patients were visually assessed for amount stroma, severity lymphocytic infiltrate at margins presence lymphoid follicles. Somatic 2134 individuals....
Abstract Persistent symptoms are common after SARS-CoV-2 infection but the correlation with objective measures is unclear. We utilized deCODE Health Study to compare multiple and physical between 1,721 Icelanders prior (cases) 546 contemporary 13,842 historical controls. Cases participated in study five 17 months acute infection. One percent reported still suffering severe more than a year 46 of 88 explored associated infection, most significantly disturbed smell taste, memory disturbance,...