A5078560571- Cancer Cells and Metastasis
- Genetic Associations and Epidemiology
- Iron Metabolism and Disorders
- Atrial Fibrillation Management and Outcomes
- Hemoglobinopathies and Related Disorders
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- Gastrointestinal disorders and treatments
- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Protease and Inhibitor Mechanisms
- Advanced Proteomics Techniques and Applications
- Neonatal Respiratory Health Research
- Folate and B Vitamins Research
- Medical Imaging and Pathology Studies
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Congenital Diaphragmatic Hernia Studies
- Gastric Cancer Management and Outcomes
- Lipid Membrane Structure and Behavior
deCODE Genetics (Iceland)
2018-2025
University of Iceland
2016-2025
Amgen (Canada)
2024
National University Hospital of Iceland
2005-2018
Reykjavík University
2006-2015
UiT The Arctic University of Norway
2015
The Maria Sklodowska-Curie National Research Institute of Oncology
2015
University Hospital of North Norway
2015
Brigham and Women's Hospital
2011
University of Milano-Bicocca
2004
Gastrointestinal stromal tumor (GIST) is a newly defined clinical and pathologic entity. This study examines the whole population-based incidence of GIST as well risk stratification schemes. All patients diagnosed in Iceland with gastrointestinal mesenchymal over years 1990-2003 were evaluated an immunohistochemical panel including staining for c-kit. The age-adjusted was calculated. Size, mitotic rate per 50 HPF various other parameters evaluated. Each categorized into 1 4 recently NIH...
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
Fibronectin (FN) matrix assembly is a cell-dependent process mediated by cell surface-binding sites for the 70-kDa amino-terminal region of FN. We have shown recently that lysophosphatidic acid (LPA) stimulator FN assembly. Disruption microtubules has been to mimic some intracellular effects LPA including formation actin stress fibers and myosin light chain phosphorylation. compared microtubule disruption on binding cytoskeleton organization. The nocodazole or vinblastine increased adherent...
BACKGROUND In a recent Finnish study, ferritin was suggested to be an independent risk factor for acute myocardial infarction. This study that high levels of iron stores might thus atherogenic and possibly explain partly the sex difference in incidence ischemic heart disease. METHODS AND RESULTS A randomly selected group (n = 2036), men women aged 25 74 years, were examined between June September 1983. All classic factors coronary artery disease measured as well basic hematologic parameters...
Purpose Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely. Patients Methods We identified 11 population-based series patients with GIST through a literature search pooled individual data from 3,067 treated macroscopically complete excision. Mutation analysis was done 1,505 tumors. analyzed associations between PDGFRA recurrence-free survival (RFS) in...
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from single hematopoietic stem cell lineage. Using whole-genome sequencing 45,510 Icelandic and 130,709 UK Biobank participants combined with mutational barcode method, we identified 16,306 people CH. Prevalence approaches 50% in elderly participants. Smoking demonstrates dosage-dependent impact on risk CH associates several smoking-related diseases. Contrary to published claims, find no evidence...
Abstract Gene promoter and enhancer sequences are bound by transcription factors depleted of methylated CpG sites (cytosines preceding guanines in DNA). The absence CpGs these typically correlates with increased gene expression, indicating a regulatory role for methylation. We used nanopore sequencing to determine haplotype-specific methylation rates 15.3 million units 7,179 whole-blood genomes. identified 189,178 where three or more proximal were unmethylated on at least one haplotype. A...
Epithelial to mesenchymal transition (EMT) is a critical event in cancer progression and closely linked the breast epithelial stem cell phenotype. Given close interaction between vascular endothelium cells, especially at invasive front, we asked whether endothelial cells might play role EMT. Using 3D culture model demonstrate that are potent inducers of EMT D492 an immortalized line with properties. Endothelial induced mesenchymal-like (D492M) derived from D492, show reduced expression...
Lungs develop from the fetal digestive tract where epithelium invades vascular rich stroma in a process called branching morphogenesis. In organogenesis, endothelial cells have been shown to be important for morphogenesis and maintenance of organ structure. The aim this study was recapitulate human lung vitro by establishing three dimensional (3D) co-culture model epithelial were cultured endothelial-rich stroma. We used bronchial cell line (VA10) recently developed our laboratory. This...
The members of the epidermal growth factor receptor (EGFR) kinase family are important players in breast morphogenesis and cancer. EGFR2/HER2 EGFR expression have a prognostic value certain subtypes cancer such as HER2-amplified, basal-like luminal type B. Many clinically approved small molecular inhibitors monoclonal antibodies been designed to target HER2, or both. There is, however, still limited knowledge on how two receptors expressed normal epithelium, what effects they cellular...
The upper airways are lined with a pseudostratified bronchial epithelium that forms barrier against unwanted substances in breathing air. transcription factor p63, which is important for stratification of skin epithelium, has been shown to be expressed basal cells the lungs and its ΔN isoform recognized as key player squamous cell lung cancer. However, role p63 formation maintenance epithelia largely unknown. objective current study was determine expression pattern TA isoforms development...
Epithelial-stromal interaction provides regulatory signals that maintain correct histoarchitecture and homeostasis in the normal breast facilitates tumor progression cancer. However, research on role of endothelial component malignant gland has largely been neglected. The aim study was to investigate effects cells growth differentiation human epithelial a three-dimensional (3D) co-culture assay.Breast luminal myoepithelial were isolated from reduction mammoplasties. Primary established cell...