A5054445577- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Oral Health Pathology and Treatment
- Cell Adhesion Molecules Research
- Helicobacter pylori-related gastroenterology studies
- Soft tissue tumor case studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Tendon Structure and Treatment
- Gastroesophageal reflux and treatments
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Shoulder Injury and Treatment
- Protease and Inhibitor Mechanisms
- Coronary Interventions and Diagnostics
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Peptidase Inhibition and Analysis
- Acute Myocardial Infarction Research
- Sports injuries and prevention
University Hospital of North Norway
2011-2022
UiT The Arctic University of Norway
2012-2022
Oslo University Hospital
2019
Haukeland University Hospital
2019
The Maria Sklodowska-Curie National Research Institute of Oncology
2015
Centre for Health Evaluation and Outcome Sciences
2007
University of British Columbia
2007
Purpose Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely. Patients Methods We identified 11 population-based series patients with GIST through a literature search pooled individual data from 3,067 treated macroscopically complete excision. Mutation analysis was done 1,505 tumors. analyzed associations between PDGFRA recurrence-free survival (RFS) in...
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our understanding of the sarcoma landscape, we quantified characterized tumor-associated macrophage infiltration expression targetable macrophage-related CD47/SIRPα across types. We surveyed immunohistochemical CD68, CD163, CD47, SIRPα tissue microarrays 1242...
Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid have been detected in various types cancer, where their presence is found to predict favourable outcome. purpose the present study was evaluate incidence oral carcinomas, if present, analyse whether they were associated with clinical Tumour samples from 80 patients carcinoma...
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal of gastrointestinal tract. This typically expresses KIT, and has KIT or PDGFRA activating mutation. In this study we evaluated 89 GISTs diagnosed in Northern Norway during a 30‐year period. exons 8, 9, 11, 13, 17 were analyzed by PCR amplification direct sequencing. Subsequently PDGRA 12, 14, 18 wild‐type cases. mutations found 66 cases (75%), 9 (10%). Most exon 11 mutations, with 58 Tumors Kit point had significantly...
Background. The Norwegian Rectal Cancer Project was initated in 1993 with the aims of improving surgery, decreasing local recurrence rates, survival, and establishing a national rectal cancer registry. Here we present results from Colorectal Registry (NCCR) to 2010.Material methods. A total 15 193 patients were diagnosed Norway 1993–2010, registered clinical data regarding diagnosis, treatment, locoregional recurrences distant metastases. Of these, 10 796 non-metastatic disease underwent...
Soft-tissue sarcomas are a group of malignant tumours whose clinical management is complicated by morphological heterogeneity, inadequate molecular markers and limited therapeutic options. Receptor tyrosine kinases (RTKs) have been shown to play important roles in cancer, both as targets prognostic biomarkers. An initial screen gene expression data for 48 RTKs 148 showed that ROR2 was expressed subset leiomyosarcoma (LMS), gastrointestinal stromal tumour (GIST) desmoid-type fibromatosis...
The main aim of the study was to evaluate if patients with oral squamous carcinomas in Northern Norway differ from other countries regard clinicopathological characteristics and also influence risk factors. Such a comparison is demographical interest, important for interpretation result studies on prognostic biomarkers. We describe 133 North Norwegian diagnosed cell carcinoma cavity period 1986–2002, significance different cohort consisted 69 men 64 women, giving male/female ratio 1.1....
Population‐based incidence and survival data for gastrointestinal stromal tumor (GIST) are sparse due to the fact that GIST is a rather novel entity both clinically pathologically, has not been registered as separate in population‐based cancer registries. The aim of present study was reclassify all mesenchymal tumors within defined population northern Norway over time‐span 30 years with purpose estimating trends survival. One hundred forty‐one patients neoplasms digestive tract were...
Background The majority of oral cavity cancers arise in the tongue. aim this study was to evaluate prognostic value tumor budding tongue squamous cell carcinoma, both as a separate variable and combination with depth invasion. We also assessed impact 8th edition American Joint Committee on Cancer's TNM classification (TNM8), where invasion (DOI) supplements diameter size (T) categorization. Methods Patients diagnosed primary carcinoma were evaluated retrospectively. Spearman bivariate...
Abstract Background Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mut ) or KRAS mutation have an inferior prognosis after liver lung surgery, whereas the prognostic role in context of peritoneal metastasis (PM) cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been less investigated. Methods In total, 257 patients non-appendiceal PM-CRC were included from Norwegian National Unit for CRS-HIPEC. Results 180 received CRS - HIPEC Mitomycin...
We have previously reported that the dendritic cell (DC) functional index cytokine interleukin‐12 was significantly decreased in colorectal carcinoma (CRC) tissues. In this study, DC infiltration pattern and density of mature DCs (mDCs; labeled by anti‐CD83 anti‐CD208) immature (iDCs; anti‐CD1α) were characterized using immunohistochemistry (IHC) tissue samples from 23 patients with CRC, 33 adenoma (CRA), 19 healthy controls. addition, function inhibitor cyclooxygenase‐2 (COX‐2) downstream...
Oral squamous cell carcinoma (OSCC) is often associated with metastatic disease and a poor 5 year survival rate. Patients diagnosed small tumours generally have more favourable outcome, but some of these are aggressive lead to early death. To avoid harmful overtreatment patients prognosis, there need for predictive biomarkers that can be used treatment stratification. In this study we assessed the possibility use components plasminogen activator (PA) system as prognostic markers OSCC outcome...
Ten patients, age 60 (48–75 years), with osteoarthritis (OA) of the hip and 10 82.5 (60–90 fracture collum femoris (FCF; minimum Garden stage III) underwent an open biopsy procedure from internal obturator tendon in conjunction a total replacement. The histological evaluation revealed that all samples OA group scar tissue; corresponding was found 50% patients FCF ( P =0.02). There were also more GAGs =0.023) calcium deposits =0.001) group. ultrastructural fewer small medium‐sized fibrils...
Objectives Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization important to follow for future trends. The aim this retrospective study was present a large cohort primary carcinoma from all four health regions Norway, with descriptive clinicopathological characteristics five-year survival outcomes. Materials methods Patients diagnosed treatment-naïve at university hospitals in Norway between 2005–2009 were retrospectively included study....
Background: Recent availability of tests for Helicobacter pylori antigens in stool samples has provided potentially useful tools epidemiological studies and clinical settings. The aim this study was to evaluate a monoclonal antibody-based H. antigen test the primary diagnosis infection, performance after patients were treated with lanzoprazole, eradication therapy. Methods: included 122 dyspeptic patients. At gastroscopy, biopsy specimens obtained culture histology. Stool [[Formula: See...