A5084395158- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Eosinophilic Disorders and Syndromes
- Advanced X-ray and CT Imaging
- Intraperitoneal and Appendiceal Malignancies
- Multiple and Secondary Primary Cancers
- Diverticular Disease and Complications
- HIV/AIDS Research and Interventions
- Angiogenesis and VEGF in Cancer
- Thermoregulation and physiological responses
- Clinical practice guidelines implementation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Imperial College London
2016-2025
Royal Marsden Hospital
2015-2025
Gilead Sciences (United States)
2023-2025
Hammersmith Hospital
2004-2024
Chelsea and Westminster Hospital NHS Foundation Trust
2024
Royal Marsden NHS Foundation Trust
2014-2023
National Institutes of Health
2012-2023
University Hospital of Wales
1999-2022
Croydon University Hospital
2006-2021
Emory University
2019-2021
To evaluate signal intensity and border characteristics of lymph nodes at high-spatial-resolution magnetic resonance (MR) imaging in patients with rectal cancer to compare these findings size prediction nodal status.Forty-two who underwent total mesorectal excision the rectum determine if they had carcinoma were studied preoperative thin-section MR imaging. Lymph harvested from 42 transversely sectioned surgical specimens. The slice each node was carefully matched its location on...
Abstract Background The aim was to determine the accuracy of preoperative magnetic resonance imaging (MRI) in evaluation pathological prognostic factors that influence local recurrence and survival rectal cancer. Methods Ninety-eight patients undergoing total mesorectal excision for biopsy-proven cancer were assessed prospectively using high-resolution MRI tumour (T) nodal (N) staging node metastasis classification, depth extramural spread, presence or absence venous invasion, a threatened...
To assess magnetic resonance imaging (MRI) and pathologic staging after neoadjuvant therapy for rectal cancer in a prospectively enrolled, multicenter study.In prospective cohort study, 111 patients who had treated by were assessed response MRI pathology T, N circumferential resection margin (CRM) status. Tumor regression grade (TRG) was also MRI. Overall survival (OS) estimated using the Kaplan-Meier product-limit method, Cox proportional hazards models used to determine associations...
To assess local recurrence, disease-free survival, and overall survival in magnetic resonance imaging (MRI)-predicted good prognosis tumors treated by surgery alone.The MERCURY study reported that high-resolution MRI can accurately stage rectal cancer. The routine policy most centers involved the was primary alone MRI-predicted II or less "good prognosis" III with selective avoidance of neoadjuvant therapy.Data were collected prospectively on all patients included who staged as MRI-defined...
The prognostic relevance of preoperative high-resolution magnetic resonance imaging (MRI) assessment circumferential resection margin (CRM) involvement is unknown. This follow-up study 374 patients with rectal cancer reports the relationship between MRI CRM staging, American Joint Committee on Cancer (AJCC) TNM stage, and clinical variables overall survival (OS), disease-free (DFS), time to local recurrence (LR).Patients underwent protocol pelvic MRI. Tumor distance mesorectal fascia ≤ 1 mm...
To evaluate neoadjuvant capecitabine/oxaliplatin before chemoradiotherapy (CRT) and total mesorectal excision (TME) in newly diagnosed patients with magnetic resonance imaging (MRI) -defined poor-risk rectal cancer.MRI criteria for cancer were tumors within 1 mm of fascia (ie, circumferential resection margin threatened), T3 at or below levators, extending > = 5 into perirectal fat, T4 tumors, T1-4N2 tumors. Patients received 12 weeks followed by concomitant capecitabine radiotherapy. TME...
PURPOSE: To evaluate the accuracy of thin-section magnetic resonance (MR) imaging (in-plane resolution, 0.6 × mm) in preoperative assessment depth extramural tumor infiltration, which is a major prognostic indicator rectal cancer. MATERIALS AND METHODS: In prospective study 28 consecutive patients, MR was performed. The stage according to TNM classification system and measured invasion matched images histopathologic slices were compared. RESULTS: Preoperative correctly indicated all 25...
Abstract Background Extramural vascular invasion (EMVI) is a poor prognostic feature in colorectal cancer. The accuracy of magnetic resonance imaging (MRI) detecting EMVI and predicting relapse-free survival (RFS) was compared retrospectively with the histological reference standard. Methods Preoperative images from patients diagnosed rectal sigmoid cancer were reviewed an MRI-EMVI score (range 0 to 4) assigned. Comparison made histology clinical outcome. Results Some 142 median follow-up...
Purpose To evaluate the addition of cetuximab to neoadjuvant chemotherapy before chemoradiotherapy in high-risk rectal cancer. Patients and Methods with operable magnetic resonance imaging–defined cancer received four cycles capecitabine/oxaliplatin (CAPOX) followed by capecitabine chemoradiotherapy, surgery, adjuvant CAPOX (four cycles) or same regimen plus weekly (CAPOX+C). The primary end point was complete response (CR; pathologic CR or, patients not undergoing radiologic CR) KRAS/BRAF...
This study aimed to validate a magnetic resonance imaging (MRI) staging classification that preoperatively assessed the relationship between tumor and low rectal cancer surgical resection plane (mrLRP).Low oncological outcomes remain global challenge, evidenced by high pathological circumferential margin (pCRM) rates unacceptable variations in permanent colostomies.Between 2008 2012, prospective, observational, multicenter (MERCURY II) recruited 279 patients with adenocarcinoma 6 cm or less...
Rectal cancer is a common and serious disease in the Western hemisphere. Optimal treatment of rectal involves multidisciplinary approach, with collaboration required between radiologists, oncologists, surgeons, pathologists to achieve local control decrease rate recurrence. Several studies have been published that show ability accurately stage magnetic resonance (MR) imaging. Moreover, advances preoperative therapies require accurate staging MR imaging select those patients who may benefit...
FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition cancers is unknown. In a translational clinical trial, we show that gastric with high-level clonal amplification have high rate the selective inhibitor AZD4547, whereas subclonal or low-level did not respond. Using cell lines patient-derived xenograft models, initiates distinct oncogene addiction phenotype, characterized by FGFR2-mediated transactivation of alternative receptor kinases,...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...