A5079536033- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Insurance, Mortality, Demography, Risk Management
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Health disparities and outcomes
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Global Health Care Issues
- Cardiac and Coronary Surgery Techniques
- Urban, Neighborhood, and Segregation Studies
- Influenza Virus Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Migration and Labor Dynamics
Maidstone and Tunbridge Wells NHS Trust
2018-2023
Maidstone Hospital
2002-2021
University of Southampton
2020
Tunbridge Wells Hospital
2019
Universitat Autònoma de Barcelona
2015
Queen Elizabeth Hospital
2012
Hospital Universitario Fundación Jiménez Díaz
2012
Fondazione IRCCS Istituto Nazionale dei Tumori
2012
Regional Cancer Center
2011
European Institute of Oncology
2011
This multicenter, randomized trial compared capecitabine plus oxaliplatin (XELOX) with bolus fluorouracil (FU) and folinic acid (FA) as adjuvant therapy for patients stage III colon cancer.Patients who had undergone curative resection were randomly assigned to XELOX (oxaliplatin 130 mg/m(2) on day 1 1,000 twice daily days 14 every 3 weeks 24 weeks) or a standard FU/FA regimen (Mayo Clinic Roswell Park 32 weeks). The primary study end point was disease-free survival (DFS).The...
To evaluate neoadjuvant capecitabine/oxaliplatin before chemoradiotherapy (CRT) and total mesorectal excision (TME) in newly diagnosed patients with magnetic resonance imaging (MRI) -defined poor-risk rectal cancer.MRI criteria for cancer were tumors within 1 mm of fascia (ie, circumferential resection margin threatened), T3 at or below levators, extending > = 5 into perirectal fat, T4 tumors, T1-4N2 tumors. Patients received 12 weeks followed by concomitant capecitabine radiotherapy. TME...
BackgroundTherapeutic antibodies targeting EGFR have activity in advanced colorectal cancer, but results from clinical trials are inconsistent and the population which most benefit is derived uncertain. Our aim was to assess addition of panitumumab irinotecan pretreated cancer.MethodsIn this open-label, randomised trial, we enrolled patients who had cancer progressing after fluoropyrimidine treatment with or without oxaliplatin 60 centres UK. From December, 2006 until June, 2008, molecularly...
Purpose To report the final efficacy findings and biomarker analysis from NO16968 trial comparing bolus fluorouracil/folinic acid (FU/FA) with capecitabine plus oxaliplatin (XELOX) in resected stage III colon cancer. Patients Methods After curative resection, patients were randomly assigned to receive XELOX, as 130 mg/m 2 on day 1 1,000 twice daily days 14 every 3 weeks, or FU/FA, Mayo Clinic Roswell Park regimens, for 6 months. The primary end point was disease-free survival (DFS)....
BackgroundThe interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction progression-free survival allocated to cetuximab plus chemotherapy compared those given alone. The focus present was assess effect on overall survival.MethodsNew multicentre, open-label, randomised, controlled, phase 3 trial. Adult (aged ≥18 years) KRAS wild-type (codons 12, 13, and 61) or suboptimally metastases WHO performance status 0–2...
Using data from the National Survey of Black Americans (NSBA), this study develops and tests a theory gendered colorism among African Americans. The NSBA was collected by black interviewers includes on survey respondents' skin color interviewers' subjective assessment physical attractiveness. These allow for unique investigation how consciously or unconsciously influences attractiveness American adults. As predicted, results indicate that tone ratings assigned to women in compelling,...
This paper investigates the social and economic circumstances of childhood that predict probability survival to age 85 among African–Americans. It uses a unique study design in which survivors are linked their records U.S. Censuses 1900 1910. A control group race-matched children is drawn from Public Use Samples for these censuses. concludes factors most predictive farm background, having literate parents, living two-parent household. Results support interpretation death risks positively...
To report the results of a planned safety analysis from phase III trial comparing capecitabine plus oxaliplatin (XELOX) with bolus fluorouracil/leucovorin (FU/LV) as adjuvant therapy for stage colon cancer.Patients carcinoma were randomly assigned to receive either XELOX (intravenous oral capecitabine; 3-week cycle eight cycles) or standard intravenous FU/LV administered Mayo Clinic (Mayo; Rochester, MN) Roswell Park (RP; Buffalo, NY) regimen similar length time. A total 1,886 patients...
Using a longitudinal design that links sample of southern-reared African American men to their childhood census records (collected in 1920), this study attempts replicate recent findings documenting the influence skin color on socioeconomic attainment Americans. The used classify Americans as either black or mulatto, allowing for unique investigation stratification adult life. Consistent with previous research, point importance phenotypic characteristics influencing life chances Subjects...
This analysis aims to evaluate routine carcino-embryonic antigen (CEA) and computed tomography (CT) of thorax, abdomen, pelvis as part protocol-specified follow-up policy for colorectal cancer (CRC).Patients with resected stage II III CRC were randomly assigned bolus fluorouracil/leucovorin or protracted venous infusion fluorouracil. Following completion chemotherapy, patients seen in clinic at regular intervals 5 years. CEA was measured each visit, CT performed 12 24 months after...
The purpose of the study was to establish optimal dose capecitabine (X) be used within a multicentre, randomised evaluating potential roles oxaliplatin (O) and X in chemonaive patients (pts) with advanced oesophagogastric cancer. Two by two design used, pts were one four regimens stratified for extent disease, performance status (PS) centre. treatment are epirubicin, cisplatin, 5-fluorouracil (ECF), EOF, ECX or EOX. Doses: E 50 mg m(-2), C 60 m(-2) O 130 i.v. 3 weekly; F 200 day(-1) 500...
The purpose of this study was to determine whether epirubicin, cisplatin and infused 5FU (ECF) improves overall survival (OS) compared 5FU, etoposide leucovorin (FELV) in patients with previously untreated advanced biliary cancer a prospective randomised study. Patients were randomly assigned receive ECF or bolus (FELV). primary end point OS secondary points objective response rate (ORR), failure-free (FFS), quality life (QOL) toxicity. In all, 54 recruited 27 each arm. median for 9.02...
PURPOSE: To compare protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin (MMC) in patients advanced pancreatic cancer a multicenter, prospectively randomized study. PATIENTS AND METHODS: Two hundred eight were to (300 mg/m 2 /d for maximum of 24 weeks) or MMC (7 every 6 weeks four courses). The major end points tumor response, survival, toxicity, and quality life (QOL). RESULTS: two treatment groups balanced baseline demographic factors, 62% had metastatic...
The influence of interviewers' race on skin color classification for white and African American survey respondents is explored using data from the Multi-City Study Urban Inequality (conducted 1992 to 1994). As hypothesized, bivariate multi-variate results reveal a compelling race-of-the-interviewer effect both black respondents: White interviewers reported tones as substantially darker than did interviewers. In turn, categorized much lighter Results also indicate that perceived greater...
PURPOSE There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal adenocarcinoma, and a definition LN response lacking. This study aimed to evaluate how influences survival surgery adenocarcinoma. METHODS Multicenter cohort patients with adenocarcinoma treated followed by surgical resection at five high-volume centers in United Kingdom. LNs retrieved esophagectomy were examined given score (LNRS)—LNRS 1,...
Using a longitudinal design that links sample of southern-reared African American men to their childhood census records (collected in 1920), this study attempts replicate recent findings documenting the influence skin color on socioeconomic attainment Americans. The used classify Americans as either black or mulatto, allowing for unique investigation stratification adult life. Consistent with previous research, point importance phenotypic characteristics influencing life chances Subjects...
PURPOSE Phase II studies have shown that the combination of interferon alfa-2b (IFN) and fluorouracil (5-FU) is active in patients with metastatic colon cancer. This study was designed to investigate whether treatment IFN 5-FU could improve response rate, duration response, or survival compared alone. PATIENTS AND METHODS Patients histologically confirmed advanced colorectal cancer were randomized receive 750 mg/m2/d by continuous infusion for 5 consecutive days followed weekly bolus mg/m2...