Ailsa Sita-Lumsden
A5036133691- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Economic and Financial Impacts of Cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Healthcare cost, quality, practices
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 and COVID-19 Research
- Gestational Trophoblastic Disease Studies
- Prostate Cancer Treatment and Research
- Prenatal Screening and Diagnostics
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- RNA Interference and Gene Delivery
- Vitamin D Research Studies
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
Guy's and St Thomas' NHS Foundation Trust
2007-2024
St Thomas' Hospital
2009-2023
Imperial College Healthcare NHS Trust
2012-2020
Charing Cross Hospital
2013-2020
University College London
2019
Royal Free London NHS Foundation Trust
2019
Royal Marsden NHS Foundation Trust
2019
University College London Hospitals NHS Foundation Trust
2019
Imperial College London
2011-2017
The University of Western Australia
2017
Post-molar pregnancy gestational trophoblastic tumours (GTT) have been curable with chemotherapy treatment for over 50 years. Because of the rarity diagnosis, detailed structured information on prognosis, escalations and outcome is limited.We reviewed demographics, prognostic variables, course clinical outcomes post-mole GTT patients treated at Charing Cross Hospital between 2000 2009.Of 618 women studied, 547 had a diagnosis complete mole, 13 mole twin conception 58 partial moles. At...
MicroRNAs (miRs) play an important role in the development of many complex human diseases and may have tumour suppressor or oncogenic (oncomir) properties. Prostate cancer is initially androgen-driven disease, androgen receptor (AR) remains a key driver growth even castration-resistant tumours. However, AR-mediated oncomiR pathways remain to be elucidated. We demonstrate that miR-27a androgen-regulated oncomir prostate cancer, acting via targeting AR corepressor, Prohibitin (PHB). Increasing...
The national registration and treatment service for molar pregnancies in the UK allows collection of accurate data on this relatively rare diagnosis. In England Wales, between 2000 2009, 5,793 patients with complete moles 7,790 partial were registered, compared a total 8,242,511 conceptions. overall pregnancy incidence was 1 every 607 conceptions (complete mole 1:1,423; 1:1,058), but major variations age. For moles, risk varied from < 1:1,000 ages 18-40, to 1:156 women aged 45 1:8 those 50...
Whether the severity and mortality of COVID-19 in patients with cancer have improved terms disease management capacity is yet to be defined.To test whether from among during course pandemic.OnCovid a European registry that collects data on consecutive solid or hematologic COVID-19. This multicenter case series study included real-world 35 institutions across 6 countries (UK, Italy, Spain, France, Belgium, Germany). update diagnosed between February 27, 2020, February, 14, 2021. Inclusion...
As well as its role in the regulation of calcium metabolism, vitamin D is an immunoregulatory hormone. Epidemiological evidence also suggests a link between deficiency and tuberculosis (TB). A study was undertaken to examine serum concentrations before treatment patients with active TB their contacts from same ethnic social background investigate relative contributions diet sunlight exposure.
<bold>Background:</bold> There is insufficient evidence to support clinical decision-making for cancer patients diagnosed with COVID-19 due the lack of large studies. <bold>Methods:</bold> We used data from a single UK Cancer Center assess demographic/clinical characteristics 156 confirmed diagnosis between 29 February and 12 May 2020. Logistic/Cox proportional hazards models were identify which demographic and/or associated severity/death. <bold>Results:</bold> 128 (82%) presented...
Abstract Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated COVID-19 death. Methods Data on all a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre King’s College Hospital between 29 February 31 July 2020 was used. Cox proportional hazards regression performed to identify which factors were mortality....
PURPOSE There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal adenocarcinoma, and a definition LN response lacking. This study aimed to evaluate how influences survival surgery adenocarcinoma. METHODS Multicenter cohort patients with adenocarcinoma treated followed by surgical resection at five high-volume centers in United Kingdom. LNs retrieved esophagectomy were examined given score (LNRS)—LNRS 1,...
Highly abundant in cells, microRNAs (or miRs) play a key role as regulators of gene expression. A proportion them are also detectable biofluids making ideal noninvasive biomarkers for pathologies which miR levels aberrantly expressed, such cancer. Peptide nucleic acids (PNAs) engineered uncharged oligonucleotide analogues capable hybridizing to complementary with high affinity and specificity. Herein, novel PNA-based fluorogenic biosensors have been designed synthesized that target prostate...
Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by progression and COVID-19. We investigated inflammation as driver of severity mortality from COVID-19, evaluating the prognostic role commonly used indices in SARS-CoV-2-infected patients accrued OnCovid study. Methods In multicenter cohort Europe, we evaluated dynamic changes neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte (PLR);...
427 Background: A subset of pts with advanced oesophago-gastric adenocarcinoma (OGA) are characterised by deficient DNA damage repair (DDR) providing a rationale for PARP inhibition (PARPi) in these tumours. Potential activity was observed the phase 3 gastric cancer trial Olaparib + paclitaxel, however efficacy monotherapy and response biomarkers have not been established. Herein we report primary clinical results from SOlar trial. Methods: is prospective, open label, single arm II using...
Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated the development COVID-19 sequelae.
PURPOSE Although representing the majority of newly diagnosed cancers, patients with breast cancer appear less vulnerable to COVID-19 mortality compared other malignancies. In absence on active therapy included in vaccination trials, a contemporary real-world evaluation outcomes during various pandemic phases, as well impact vaccination, is needed better inform clinical practice. METHODS We morbidity and among across prevaccination (February 27, 2020-November 30, 2020), Alpha-Delta (December...
The Uterine Artery Pulsatility Index (UAPI) is an ultrasound measure of tumour vascularity. In this study, we hypothesised that a UAPI ≤ 1 (high vascularity) would identify women with gestational trophoblastic neoplasia (GTN) at increased risk resistance to first-line single-agent methotrexate (MTX-R).Single-centre cohort study.Charing Cross Hospital, UK national centre for the treatment disease.All GTN FIGO score 5-6 treated (n = 92), between 1999 and 2011, Charing Hospital.UAPI was...
To investigate the demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma.A retrospective national population-based study.UK 1995-2015.A total 234 women with a diagnosis choriocarcinoma, in absence prior molar pregnancy, managed at UKs two trophoblast centres London Sheffield.Retrospective review patient's demographic clinical data. Comparison contemporary UK birth pregnancy statistics.Incidence statistics for choriocarcinoma across maternal age groups....