A5032637708- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Mycorrhizal Fungi and Plant Interactions
- Antifungal resistance and susceptibility
- Actinomycetales infections and treatment
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Yeasts and Rust Fungi Studies
- Mycotoxins in Agriculture and Food
- Lichen and fungal ecology
- Nanoplatforms for cancer theranostics
- Sinusitis and nasal conditions
- Nanoparticle-Based Drug Delivery
- Fungal Biology and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Functional Brain Connectivity Studies
- Microbial infections and disease research
- Graphene research and applications
- Cardiac Structural Anomalies and Repair
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child and Adolescent Psychosocial and Emotional Development
- Mobile Health and mHealth Applications
- Aortic Disease and Treatment Approaches
- Plant Disease Resistance and Genetics
- Aquaculture disease management and microbiota
Radboud University Nijmegen
2020-2025
Radboud University Medical Center
2020-2025
Canisius-Wilhelmina Ziekenhuis
2020-2024
Centre for Addiction and Mental Health
2022-2024
University College London
2023-2024
St. Luke's University Health Network
2023-2024
University at Buffalo, State University of New York
2024
Great Ormond Street Hospital
2024
The University of Texas at Dallas
2024
City University of New York
2022-2023
Abstract A severe outbreak of highly virulent and multi-resistant dermatophytosis by species in the Trichophyton mentagrophytes / T . interdigitale complex is ongoing India. The correct identity etiologic agent a much-debated issue. In order to define limits, taxonomic study was undertaken combining molecular, morphological, physiological characteristics as evidence classification. Molecular show that T. s. str can be distinguished with difficulty from each other, but are unambiguously...
Due to its high degree of natural resistance terbinafine in vitro and tendency spread globally from the Indian subcontinent, emerging dermatophyte Trichophyton indotineae has become a major concern dermatology. Herein, we present first report T. mainland China. The transmission fungus Guizhou Province central China eventual host susceptibilities were investigated. We studied 31 strains mentagrophytes complex outpatient clinics our hospital collected during past 5 years. set comprised four...
Eumycetoma is a chronic fungal infection characterised by large subcutaneous masses and the presence of sinuses discharging coloured grains. The causative agents black-grain eumycetoma mostly belong to orders Sordariales Pleosporales. aim present study was clarify phylogeny taxonomy pleosporalean agents, viz. Madurella grisea, Medicopsis romeroi (syn.: Pyrenochaeta romeroi), Nigrograna mackinnonii (syn. mackinnonii), Leptosphaeria senegalensis, L. tompkinsii, Pseudochaetosphaeronema larense....
During the past decade, a prolonged and serious outbreak of dermatophytosis due to terbinafine-resistant novel species in Trichophyton mentagrophytes - T. interdigitale complex has been ongoing India, it spread several European countries. The objective this study was investigate molecular background squalene epoxidase ( SQLE ) gene order understand risk emergence multiresistance dermatophytes.
The rapid pace of name changes medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources change which have different drivers, at the species versus genus level. Some suggestions are made here to reduce number changes. urge taxonomists provide diagnostic markers taxonomic novelties. Given instability phylogenetic trees due variable taxon sampling, we advocate maintain genera largest possible size. Reporting...
The Fusarium solani species complex (FSSC) has been studied intensively but its association with legumes, particularly under European agro-climatic conditions, is still poorly understood. In the present study, we investigated phylogenetic relationships and aggressiveness of 79 isolates FSSC collected from pea, subterranean clover, white clover winter vetch grown diverse soil conditions within Temperate Mediterranean Europe. were characterized by sequencing tef1 rpb2 loci greenhouse assays....
Fusarium species are emerging causative agents of superficial, cutaneous and systemic human infections. In a study the prevalence genetic diversity 464 fungal isolates from dermatological ward in Thailand, 44 strains (9.5%) proved to belong genus Fusarium. Species identification was based on sequencing portion translation elongation factor 1-alpha (tef1-α), rDNA internal transcribed spacer RNA-dependent polymerase subunit II (rpb2). Our results revealed that 37 (84%) belonged solani complex...
Abstract Chaetothyriales is an ascomycetous order within Eurotiomycetes. The particularly known through the black yeasts and filamentous relatives that cause opportunistic infections in humans. All species are consistently melanized. Ecology habitats of highly diverse, often rather extreme terms exposition toxicity. Families defined on basis evolutionary history, which reconstructed by time divergence concepts comparative biology using stochastical character mapping a multi-rate Brownian...
A resistant and hypervirulent dermatophyte from India has been described as a taxonomic novelty, Trichophyton indotineae, species of the mentagrophytes complex. Rapid detection correct identification closely similar dermatophytes with different predilections are essential for efficient clinical management. We evaluated efficacy rapid diagnostic methods environmental strains in T. The included Real-time-PCR, DermaGenius, LAMP, MALDI-ToF MS, using rDNA ITS sequences standard. results show that...
Abstract The order Onygenales is classified in the class Eurotiomycetes of subphylum Pezizomycotina . Families this have classically been isolated from soil and dung, two lineages contain causative agents superficial, cutaneous systemic infections mammals. ecology habitat choices species are driven mainly by keratin cellulose degradation abilities. present study aimed to investigate whether ecological trends members can be interpreted an evolutionary sense, linking phylogenetic parameters...
ABSTRACT The present paper includes a meta-analysis of literature data on 318 species fungi belonging to 34 orders in their response 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends MIC results at the ordinal level were visualized. European Committee Antimicrobial Susceptibility Testing Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints used as staff gauge evaluate...
Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis one of the prevalent etiologic agents arid Northeastern Africa. The source has not been clarified. Subcutaneous inoculation from plant thorns hypothesized, but attempts detect fungus relevant material have remained unsuccessful. present study aims find clues reveal natural habitat species using phylogenetic approach, i.e. by comparison neighboring taxa with...
ABSTRACT Appropriate diagnosis and treatment of eumycetoma may vary significantly depending on the causative agent. To date, most common fungus causing mycetoma worldwide is Madurella mycetomatis . This species fails to express any recognizable morphological characteristics, reliable identification can therefore only be achieved with application molecular techniques. Recombinase polymerase amplification (RPA) loop-mediated isothermal (LAMP) are proposed as alternatives phenotypic methods....
The Trichophyton rubrum species complex comprises commonly encountered dermatophytic fungi with a worldwide distribution. members of the usually have distinct phenotypes in culture and cause different clinical symptoms, despite high genome similarity. In order to better delimit within complex, molecular, phenotypic, physiological characteristics were combined reestablish natural concept.
The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because high recurrence rates, which often leads to complications and unnecessary amputations, its comparatively cost in endemic areas. Hence, an effective affordable drug required improve therapeutic outcome. E1224 a potent orally available, broad-spectrum triazole currently being developed for the Chagas disease. prodrug that rapidly converted ravuconazole. Plasma levels are low transient, therapeutically active...
ABSTRACT The first yellow-grain fungal mycetoma, in a 60-year-old man from Central Sudan, is reported. Morphological and phylogenetic analysis of the ribosomal small subunit (SSU), large (LSU), internal transcribed spacer (ITS), β-tubulin ( BT2 ), actin ACT1 elongation factor TEF1 ) genes revealed that isolate deviated any known agent mycetoma; it clustered genus Pleurostoma (anamorph genus, Pleurostomophora order Calosphaeriales . novel species, here named ochracea , characterized by...
Accurate identification of mycetoma causative agent is a priority for treatment. However, current tools are far from being satisfactory both reliable diagnosis and epidemiological investigations. A rapid, simple, highly efficient molecular based method agents black grain eumycetoma introduced, aiming to improve diagnostic in endemic areas. Rolling Circle Amplification (RCA) uses species-specific padlock probes isothermal DNA amplification. The tests were on ITS sequences developed...
Fungal mycetoma (eumycetoma) represents one of the most difficult infections to appropriately manage. The current recommended treatment is based on extensive surgical debridement combined with prolonged antifungal therapy ketoconazole or itraconazole. Despite different phylogenetic positions black-grain eumycetoma species, they are all treated same agents. in vitro susceptibility coelomycetous agents order Pleosporales presently largely unknown. Here we determined activity eight against...
Two new species in the Fusarium fujikuroi complex (FFSC) are introduced. One of these, represented by strain CBS 454.97 was isolated from plant debris (Striga hermonthica) Sudan, while second, strains 119850 and 483.94, which originated soil Australia. Molecular analyses were performed including TEF1 spanning 576 bp region, 860 region rPB2, 500 BT2 region. Phylogenetic trees based on these regions showed that two clearly distinct all known taxa F. complex. Based phenotypic, physiological...
(1) Background: Candida auris has been reported as emerging yeast pathogen that can cause invasive bloodstream infections in healthcare settings. It is associated with high mortality rates and resistance to multiple classes of antifungal drugs difficult identify standard laboratory methods. (2) Methods: We conducted a retrospective review epidemiological, clinical, microbiological records for 23 C. fungemia cases at the Royal Hospital, tertiary care facility Oman, between 2016 2018....