Eleanor Jones
A5066390629- Tendon Structure and Treatment
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- COVID-19 and healthcare impacts
- Shoulder Injury and Treatment
- High-Velocity Impact and Material Behavior
- Palliative Care and End-of-Life Issues
- Phytase and its Applications
- COVID-19 Clinical Research Studies
- Structural Response to Dynamic Loads
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Long-Term Effects of COVID-19
- Bee Products Chemical Analysis
- Plant Micronutrient Interactions and Effects
- BRCA gene mutations in cancer
- Exercise and Physiological Responses
- Reproductive System and Pregnancy
- Hip and Femur Fractures
- Advanced Proteomics Techniques and Applications
- Sports injuries and prevention
- Gynecological conditions and treatments
- Iron Metabolism and Disorders
- Knee injuries and reconstruction techniques
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
University of Manchester
2020-2024
Australia New Zealand Gynaecological Oncology Group
2024
Manchester University NHS Foundation Trust
2020-2024
University of Saint Mary
2024
Watching Over Mothers & Babies
2024
Manchester Academic Health Science Centre
2020-2023
King's College London
2022-2023
St Mary's Hospital
2022-2023
St Mary's Hospital
2020-2021
Guy's and St Thomas' NHS Foundation Trust
2021
Increasing the intrinsic nutritional quality of crops, known as biofortification, is viewed a sustainable approach to alleviate micronutrient deficiencies. In particular, iron deficiency anemia major global health issue, but content staple crops such wheat (Triticum aestivum) difficult change because genetic complexity and homeostasis mechanisms. To identify target genes for biofortification wheat, we functionally characterized homologs VACUOLAR IRON TRANSPORTER (VIT). The genome contains...
We have isolated and characterized complete cDNAs for two isoforms (HSPDE4D4 HSPDE4A5) encoded by the human PDE4D gene, one of four genes that encode cAMP-specific rolipram-inhibited 3ʹ,5ʹ-cyclic nucleotide phosphodiesterases (type IV PDEs; PDE4 family). The HSPDE4D4 HSPDE4D5 proteins 810 746 amino acids respectively. A comparison sequences these with those encoding three other (HSPDE4D1, HSPDE4D2 HSPDE4D3) demonstrates each corresponding mRNA transcript has a unique region sequence at or...
Extracorporeal shock wave therapy (ESWT) is a noninvasive treatment for chronic tendinopathies, however little known about the in-vivo biological mechanisms of ESWT.Using microdialysis, we examined real-time response healthy and pathological tendons to ESWT.A single session ESWT was administered mid-portion Achilles tendon in thirteen individuals (aged 25.7 ± 7.0 years) patellar or six patients with tendinopathies 39.0 14.9 years).Dialysate samples from surrounding peri-tendon were collected...
Results of an experimental program systematically evaluating the deformation and fracture steel wire reinforced epoxy composite systems are presented. The involved mechanical testing in strain rate range 10 -5 to 3 /sec impact specimens using massive elastic targets at rates approximately 4 /sec. Specific results presented include static dynamic prop erties, sensitivity, information on nature character fracture, influence specimen geometry reinforce ment spacing, high speed photographs...
Abstract Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated COVID-19 death. Methods Data on all a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre King’s College Hospital between 29 February 31 July 2020 was used. Cox proportional hazards regression performed to identify which factors were mortality....
Key content Endometrial cancer (EC) is the most common gynaecological in UK. Ninety percent of women with EC present postmenopausal bleeding (PMB), but less than 10% PMB have a sinister underlying cause. National Institute for Health and Care Excellence guidance advises that symptomatic undergo urgent investigation; however, unclear premenopausal women. Current investigations PMB, including transvaginal ultrasound scan, endometrial biopsy and/or outpatient hysteroscopy, advantages...
Tendinopathies are a range of diseases characterised by degeneration and chronic tendon pain represent significant cause morbidity. Relatively little is known about the underlying mechanisms; however onset often associated with physical activity. A number molecular changes have been documented in tendinopathy such as decrease overall collagen content, increased extracellular matrix turnover protease Metalloproteinases involved homeostasis expression regulated mechanical strain. The aims this...
Topographically modified substrates are increasingly used in tissue engineering to enhance biomimicry. The overarching hypothesis is that topographical cues will control cellular response at the cell-substrate interface.The influence of anisotropically ordered poly(lactic-co-glycolic acid) (constant groove width ~1860 nm; constant line ~2220 variable depth ~35, 306 and 2046 nm) on vitro vivo osteogenesis were assessed.We demonstrate with depths approximately nm promote osteoblast alignment...
Pea seeds are widely consumed in their immature form, known as garden peas and petit pois, mostly after preservation by freezing or canning. Mature dry rich iron the form of ferritin, but little is about content, bioavailability stages seed development. Using specific antibodies in-gel staining, we show that ferritin loaded with accumulated gradually during Immunolocalization high-resolution secondary ion mass spectrometry (NanoSIMS) revealed iron-loaded was located at surface...
Early detection of endometrial cancer improves survival. Non-invasive diagnostic biomarkers would improve triage symptomatic women for investigations. This study aimed to determine the accuracy serum Cancer Antigen 125 (CA125) and Human Epididymis 4 (HE4) associated high-risk features. Serum samples from investigated gynaecological symptoms or diagnosed with were analysed CA125 HE4. Conventional metrics calculated. In total, 755 included; 397 had cancer. HE4 significantly elevated in cases...
Journal Article Benign granular-cell myoblastoma of the bronchus Get access E R Jones, Jones Preston Hall Hospital, Maidstone Search for other works by this author on: Oxford Academic Google Scholar A M Macarthur British Surgery, Volume 46, Issue 198, January 1959, Pages 420–421, https://doi.org/10.1002/bjs.18004619827 Published: 06 December 2005
R. J. P. Allan, E. Jones and D. Ritchie, Chem. Soc., 1957, 524 DOI: 10.1039/JR9570000524
Endometrial cancer is the most common gynaecological malignancy in high-income countries and its incidence rising. Early detection, aided by highly sensitive specific biomarkers, has potential to improve outcomes as treatment can be provided when it likely effect a cure. Sequential window acquisition of all theoretical mass spectra (SWATH-MS), an accurate reproducible platform for analysing biological samples, offers technological advance biomarker discovery due reproducibility, sensitivity...
Introduction Postmenopausal bleeding (PMB), the red flag symptom for endometrial cancer, triggers urgent investigation by transvaginal ultrasound scan, hysteroscopy and/or biopsy. These investigations are costly, invasive and often painful or distressing women. In a pilot study, we found that voided urine non-invasive vaginal samples from women with cancer contain malignant cells can be identified cytology. The aim of DE veloping T ests E ndometrial C ancer de ection (DETECT) Study is to...
The identity of the enzyme responsible for S-oxidation mucolytic S-substituted L-cysteine drug, S-carboxymethyl-L-cysteine (SCMC), has been actively investigated last 10 years. A genetic polymorphism exists in oxidation thioether moiety that identified as a disease susceptibility factor number degenerative diseases. This also implicated wide variation clinical response to SCMC therapy man. To date little is known about molecular enzymology this reaction but previous investigation revealed...