A5044402166- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- Frailty in Older Adults
- Ethics in Clinical Research
- Esophageal and GI Pathology
- Genital Health and Disease
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Chemokine receptors and signaling
- Urinary and Genital Oncology Studies
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- LGBTQ Health, Identity, and Policy
- FOXO transcription factor regulation
King's College London
2016-2023
Guy's Hospital
2016-2020
Sardar Vallabhbhai National Institute of Technology Surat
2020
London Cancer
2016-2017
U-M Rogel Cancer Center
2017
Guy's and St Thomas' NHS Foundation Trust
2016
St Thomas' Hospital
2016
Queen Mary University of London
2014
Neuroendocrine neoplasia (NEN) incidence is rising internationally. We aimed to evaluate the epidemiology of NEN in England and examine changes survival over time.A retrospective, population-based study using nationally representative data between 1995 2018 from National Cancer Registry Analysis Service (NCRAS) was conducted on 63,949 tumours. Age-standardized calculated Office for Statistics (ONS) data. Overall (OS) Kaplan-Meier estimator. Multivariable analysis performed an accelerated...
Abstract Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated COVID-19 death. Methods Data on all a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre King’s College Hospital between 29 February 31 July 2020 was used. Cox proportional hazards regression performed to identify which factors were mortality....
PurposeReal-World Data (RWD) studies are increasingly used to support regulatory approvals, reimbursement decisions, and changes in clinical practice for novel cancer drugs. However, few have systematically appraised their quality or compared outcomes pivotal trials.MethodsAll RWD (2010–2019) drugs approved by the Food Drug Administration (FDA) European Medicines Agency (EMA) from 2010 2015 solid organ tumours non-curative setting were identified. Quality assessment was undertaken using...
Observational studies in prostate cancer (PCa) have shown an increased risk of cardiovascular disease (CVD) following gonadotropin-releasing hormone (GnRH) agonists, whereas randomised-controlled trials no associations. Compared to GnRH antagonists less atherosclerotic effects preclinical models. We used real-world data from five countries investigate CVD agonists and PCa men. Data sources included registries, primary secondary healthcare databases. event was defined as incident or fatal...
Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with reduced risk cancer incidence number solid tumours, including prostate (PCa). However, underlying biological mechanisms these observations have not fully characterised in PCa. One hypothesis that indirect insulin lowering effect may an anti-neoplastic action as elevated and like growth factor − 1...
Aim . To explore patient experiences of a structured exercise intervention for men with prostate cancer (PCa). Sample 41 either localised or advanced PCa who had been referred programme by their physician and then subsequently consented to telephone survey. Method Participants underwent 10-week supervised within large centre hospital consisting 8 sessions. They completed short multiple choice survey, elaborating on responses where appropriate. Views expressed participants were analysed using...
Aim: Gonadotropin-releasing hormone (GnRH) agonists are used to treat men with prostate cancer (PCa). To date, no study has fully assessed patterns of adherence GnRH agonists. We investigated using data from Prostate Cancer Base Sweden (PCBaSe).Methods: PCBaSe links the National Register (NPCR) other healthcare registers and demographic databases. Men on primary or secondary between 2006–2013 entered 45 days after agonists' initiation (run-in period) exited at 3 years. Medication possession...
Background: Black men are three times more likely to develop prostate cancer (PCa) and often present with aggressive disease.Nevertheless, black consistently underrepresented in research studies.We aimed get insight into the reasons for this reduced recruitment, as it is important future include results that also applicable PCa.Methods: Two focus groups (n = 10 n 6) of males currently under treatment PCa at Guys Hospital, London, UK were held gather information regarding understanding...
Men with prostate cancer (PCa) on gonadotropin-releasing hormone agonists (GnRH) have an increased risk of cardiovascular disease (CVD) compared to men PCa not GnRH as well PCa-free men. Whether the addition androgen receptor targeted (ART) drugs further increases CVD risk, remains be fully elucidated.We investigated for castration resistant (CRPC) plus ART; abiraterone or enzalutamide vs 5,127 and 12,079 respective matched comparator in Prostate Cancer data Base Sweden (PCBaSeTraject) 4.1...
The KHP PCaBB was established in 2013 and recruits donors from the Urology or Oncology Departments at Guy's Hospital London (UK). Prostate cancer patients may be approached to give their consent for biobanking any point treatment pathway, which allows residual material earlier diagnosis transferred used by Biobank. Currently, are specifically asked donate samples of blood surplus prostate tissue as well permitting access clinical pathological data that continues added throughout course...
Objectives: To evaluate how accurate a 12-core transrectal biopsy derived low-risk prostate cancer diagnosis is for an active surveillance programme by comparing the histological outcome with that from confirmatory transperineal sector biopsy. Subjects and methods:The cohort included 166 men diagnosed low volume Gleason score 3+3 on initial who also underwent biopsy.Both techniques were performed according to standard protocols samples taken histopathology analysis.Subgroup analysis was...
Abstract One of the more recently investigated adverse long‐term side effects gonadotropin‐releasing hormone (Gn RH ) agonists for prostate cancer ( PC a) is cardiovascular disease CVD ). Studies suggest lower risk following Gn antagonists (degarelix) than agonists. This protocol describes precise codes used to extract variables from five European databases a study that compares and a. men on primary or were identified UK THIN (The Health Improvement Network) database, National Service NHS...
An inverse association between use of antiepileptic drugs (AEDs) and prostate cancer (PCa) has been suggested, putatively due to the histone deacetylases inhibitory (HDACi) properties AEDs. In a case-control study in Prostate Cancer data Base Sweden (PCBaSe), PCa cases diagnosed 2014 2016 were matched five controls by year birth county residence. AED prescriptions identified Prescribed Drug Registry. Odds ratios (ORs) 95% confidence intervals for risk estimated using multivariable...