Nikolaos Diamantis
A5069756772- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Long-Term Effects of COVID-19
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Physics of Superconductivity and Magnetism
- Glioma Diagnosis and Treatment
- Potassium and Related Disorders
- Healthcare cost, quality, practices
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Quantum many-body systems
- SARS-CoV-2 and COVID-19 Research
- Economic and Financial Impacts of Cancer
- Quantum and electron transport phenomena
- Theoretical and Computational Physics
- Childhood Cancer Survivors' Quality of Life
- Electrolyte and hormonal disorders
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Analytic Number Theory Research
- Colorectal and Anal Carcinomas
Royal Free London NHS Foundation Trust
2023-2025
Barts Health NHS Trust
2020-2023
St Bartholomew's Hospital
2023
University College London
2023
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2022
Royal Marsden Hospital
2017-2021
Royal Marsden NHS Foundation Trust
2015-2021
National and Kapodistrian University of Athens
2013-2021
Institute of Cancer Research
2015-2020
Metaxa Hospital
2014-2017
Whether the severity and mortality of COVID-19 in patients with cancer have improved terms disease management capacity is yet to be defined.To test whether from among during course pandemic.OnCovid a European registry that collects data on consecutive solid or hematologic COVID-19. This multicenter case series study included real-world 35 institutions across 6 countries (UK, Italy, Spain, France, Belgium, Germany). update diagnosed between February 27, 2020, February, 14, 2021. Inclusion...
Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by progression and COVID-19. We investigated inflammation as driver of severity mortality from COVID-19, evaluating the prognostic role commonly used indices in SARS-CoV-2-infected patients accrued OnCovid study. Methods In multicenter cohort Europe, we evaluated dynamic changes neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte (PLR);...
Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated the development COVID-19 sequelae.
PURPOSE Although representing the majority of newly diagnosed cancers, patients with breast cancer appear less vulnerable to COVID-19 mortality compared other malignancies. In absence on active therapy included in vaccination trials, a contemporary real-world evaluation outcomes during various pandemic phases, as well impact vaccination, is needed better inform clinical practice. METHODS We morbidity and among across prevaccination (February 27, 2020-November 30, 2020), Alpha-Delta (December...
Paracentesis for malignant ascites is usually performed as an in-patient procedure, with a median length of stay (LoS) 3-5 days, intermittent clamping the drain due to perceived risk hypotension. In this study, we assessed safety free drainage and feasibility cost-effectiveness daycase paracentesis.
Abstract The dynamics of a hole motion in quantum antiferromagnet has been studied the past three decades because its relationship to models related superconductivity cuprates. same problem received significant attention connection very recent experiments ultra-cold atoms optical lattices where strongly correlated electrons can be simulated. In this paper we apply diagrammatic Monte Carlo method calculate single-hole Green’s function t – J model, term is linearized, wide range imaginary-time...
BackgroundThe incidence and clinical significance of electrolyte abnormalities (EAs) in phase I trials are unknown. The objective this study is to evaluate the severity EAs, graded according CTCAE, v4.03, identify variables associated with EAs their prognostic a population.MethodsA retrospective chart review was performed 1088 cases 82 consecutively treated from 2011 2015 at Drug Development Unit Royal Marsden Hospital. Cox regression analysis examine relationship between overall survival...
IntroductionAdolescents and young adults (AYAs) diagnosed with cancer between ages 15–39 years may harbour germline variants associated predisposition. Such represent putative therapeutic targets, as somatic in the tumour. Germline tumour molecular profiling is increasingly utilised to facilitate personalisation of treatment such individuals.AimConsidering AYAs advanced solid tumours managed a specialist drug development unit (DDU), aims this study were investigate use impact of:1. genetic...
BAL101553 (lisavanbulin), the lysine prodrug of BAL27862 (avanbulin), exhibits broad anti-proliferative activity in human cancer models refractory to clinically relevant microtubule-targeting agents.
2570 Background: TF-ADC is an antibody drug conjugate composed of a TF-specific human IgG1 monoclonal conjugated to microtubule disrupting agent Monomethyl Auristatin E (MMAE). presently being tested in ongoing Phase I dose-escalation study (NCT02001623) patients (pts) with locally advanced and/or metastatic solid tumors known express TF. Methods: The primary objective assess the tolerability TF-ADC. In addition, maximum tolerated dose (MTD), pharmacokinetics and preliminary efficacy will be...
BackgroundAdolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials novel agents. The outcome of AYAs in these have not been described before.AimTo study the AYA trials.MethodsClinical trial data (defined as aged 15–39 years at diagnosis) treated Drug Development Unit, Royal Marsden Hospital, between 2002 2016, were analysed.ResultsFrom a prospectively maintained database 2631 trials, 219 (8%) identified. Major tumour types...
Background: Cancer patients are at higher risk of COVID-19 complications and mortality than the rest population. Breast cancer seem to have better prognosis when infected by SARS-CoV-2 other patients. Methods: We report a subanalysis OnCovid study providing more detailed information in breast Results: included 495 with infection. Mean age was 62.6 years; 31.5% presented one comorbidity. The most frequent subtype luminal-like ( n = 245, 49.5%) 177 (35.8%) had metastatic disease. A total 332...
The diagrammatic Monte Carlo (DiagMC) method is a numerical technique which samples the entire series of Green's function in quantum many-body systems. In this work, we incorporate flat histogram principle method, and term improved version ``flat Carlo'' method. We demonstrate superiority over standard DiagMC extracting long-imaginary-time behavior function, without incorporating any priori knowledge about by applying to polaron problem.