A5102976729- Microtubule and mitosis dynamics
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Cell death mechanisms and regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Chemical Reactions and Isotopes
- Polyamine Metabolism and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- RNA modifications and cancer
- RNA regulation and disease
- Viral-associated cancers and disorders
- Forest Ecology and Biodiversity Studies
- Radiopharmaceutical Chemistry and Applications
Basilea Pharmaceutica (Switzerland)
2015-2024
Technical University of Munich
2024
Friedrich Schiller University Jena
2023
University of Münster
2019
University of Basel
2001-2002
University of Geneva
2002
Friedrich Miescher Institute
1996-1998
Institute of Molecular and Clinical Ophthalmology Basel
1995
To protect the body efficiently from infectious organisms, leukocytes circulate as nonadherent cells in blood and lymph, migrate adherent into tissues. Circulating have first to adhere then cross endothelial lining. CD31/PECAM-1 is an adhesion molecule expressed by vascular cells, platelets, monocytes, neutrophils, naive T lymphocytes. It a transmembrane glycoprotein of immunoglobulin gene superfamily (IgSF), with six Ig-like homology units mediating leukocyte-endothelial interactions. The...
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it unclear whether multicellular CTC clusters generated this disease they can bypass the physical hurdle of blood-brain barrier. Here, we assessed presence composition at multiple time points 13 patients with progressing during an open-label phase 1/2a study microtubule inhibitor BAL101553. We observe...
Type 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic β cell mass in face insulin resistance. Changes concentration glucose play essential role regulation turnover. In human islets, elevated concentrations impair proliferation and induce apoptosis via up-regulation Fas receptor. Recently, it has been shown that caspase-8 inhibitor FLIP may divert Fas-mediated death signals into those for lymphatic cells. We observed expression cells nondiabetic...
BACKGROUND A recently cloned novel p150 protein was found to be overexpressed in human breast carcinoma. To the authors' knowledge, no data on expression any other tumors have been published previously. METHODS investigate whether of correlated with clinicopathologic stages cervical neoplasms or prognoses patients these neoplasms, authors conducted an immunohistochemical study archival formalin fixed, paraffin embedded specimens. Seventy-two precancerous lesions (CIN), 75 clinical Stage IB...
Several apoptosis-detecting methods are currently available. Many of them work intensive and require the additional use antibodies, dyes, specific substrates, or enzymatic reactions. A simple, fast, reliable method was developed to test for apoptosis necrosis using mouse human cell lines (e.g., Jurkat, A20.2J, PB3c cells) stably transfected with a vector coding green fluorescent protein (GFP) as indicator cells.Apoptosis in GFP-transfected induced either by soluble Fas-Ligand (sFasL),...
Although the response to treatment with interferon- alpha in individuals chronic hepatitis C virus (HCV) infection is negatively associated increased liver iron stores, underlying mechanisms at work have remained elusive date. The translation initiation factor 3 (eIF3) essential for HCV translation, and thus effects that perturbations on eIF3 expression were studied here.eIF3 was analyzed by TaqMan polymerase chain reaction, Northern Western blot analysis of HepG2 cells, biopsies. Functional...
Abstract Glioblastoma patients have limited treatment options. Cancer stem-like cells (CSLC) contribute to glioblastoma invasiveness and repopulation; hence, they represent promising targets for novel therapies. BAL101553 is a prodrug of BAL27862, microtubule-destabilizing agent inhibiting tumor cell proliferation through activation the spindle assembly checkpoint, which currently in phase I/II clinical development. Broad anticancer activity has been demonstrated against human cancer models,...
The eukaryotic translation initiation factor eIF3a is one of the core subunits complex eIF3, responsible for ribosomal subunit joining and mRNA recruitment to ribosome. It known play an important role in general as well specific translational regulation various gene products, among which many influence tumour development, progression, therapeutically pathways DNA damage repair. Therefore, beyond its protein synthesis, emerging regulator pathogenesis therapy response and, therefore, a...
Accurate detection and delineation of individual trees their crowns in dense forest environments are essential for management ecological applications. This study explores the potential combining leaf-off leaf-on structure from motion (SfM) data products unoccupied aerial vehicles (UAVs) equipped with RGB cameras. The main objective was to develop a reliable method precise tree stem crown deciduous forests, demonstrated at structurally diverse old-growth Hainich National Park, Germany. Stem...
Abstract Adjuvant chemotherapy reduces the incidence of distant metastasis and increases survival patients with colorectal cancer. However, predictive markers are needed to define subsets stage II III disease that may benefit from adjuvant treatment. A secreted member TNF receptor superfamily, decoy 3 (DcR3), was reported be amplified in cancer as a negative regulator Fas‐mediated apoptosis. We analyzed DcR3 gene copy number protein expression large series tumors randomized multicenter trial...
Ozonation is a powerful technique to remove micropollutants from wastewater. As chemical oxidation of wastewater comes with the formation varying, possibly persistent and toxic by-products, post-treatment ozonated effluent routinely suggested. This study explored an enzymatic treatment ozonation products using laccase Trametes versicolor. A high-performance liquid chromatography coupled high-resolution mass spectrometry (HPLC-HRMS) analysis revealed that major by-products were effectively...
ABSTRACT Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells late-stage Kaposi's sarcoma lesions but not primary effusion lymphoma cell lines. In contrast, strong expression found stimulated cells, whereas preferential mononuclear and to a lesser extent stained positive.
// Raphaël Bergès 1 , Aurélie Tchoghandjian Arnauld Sergé 2 Stéphane Honoré Dominique Figarella-Branger 3 Felix Bachmann 4 Heidi A. Lane and Diane Braguer Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France Aix Marseille INSERM, Institut Paoli-Calmettes, CRCM, APHM, CHU Timone, 13385, Basilea Pharmaceutica International Ltd., Basel, Switzerland Correspondence to: Braguer, email: diane.braguer@univ-amu.fr Lane,...
Background Threonine tyrosine kinase (TTK) and polo-like 1 (PLK1) are common essential kinases that collaborate in activating the spindle assembly checkpoint (SAC) at kinetochore, ensuring appropriate chromosome alignment segregation prior to mitotic exit. Targeting of either TTK or PLK1 has been clinically evaluated cancer patients; however, dual inhibitors have not yet pursued. Here we present vitro vivo characterization a first class, TTK/PLK1 inhibitor (BAL0891). Methods Mechanism action...
BAL101553 (lisavanbulin), the lysine prodrug of BAL27862 (avanbulin), exhibits broad anti-proliferative activity in human cancer models refractory to clinically relevant microtubule-targeting agents.
Derazantinib (DZB) is an inhibitor of fibroblast growth factor receptors 1-3 (FGFR1-3), with additional activity against colony-stimulating-factor-1 receptor (CSF1R). We have profiled the DZB in gastric cancer (GC) as monotherapy and combined paclitaxel, explored means stratifying patients for treatment. The antiproliferative potency vitro was quantified 90 tumor cell lines shown to correlate significantly FGFR expression (<0.01) but not DNA copy-number (CN) or mutations. In four GC , little...