A5084685225- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Pancreatic and Hepatic Oncology Research
- Family Dynamics and Relationships
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Mobile Health and mHealth Applications
- Child Abuse and Trauma
- HIV/AIDS Research and Interventions
- Counseling Practices and Supervision
- Global Maternal and Child Health
- Ethics and Legal Issues in Pediatric Healthcare
- Comparative and International Law Studies
- Medical Malpractice and Liability Issues
- HIV/AIDS Impact and Responses
- Family Support in Illness
- Poverty, Education, and Child Welfare
- HIV, Drug Use, Sexual Risk
- Legal Education and Practice Innovations
- Glioma Diagnosis and Treatment
University of Basel
2018-2022
Swiss Tropical and Public Health Institute
2020-2022
University Hospital of Basel
2018-2021
University of the Free State
2002-2004
The ability of circulating tumor cells (CTCs) to form clusters has been linked increased metastatic potential. Yet biological features and vulnerabilities CTC remain largely unknown. Here, we profile the DNA methylation landscape single CTCs from breast cancer patients mouse models on a genome-wide scale. We find that binding sites for stemness- proliferation-associated transcription factors are specifically hypomethylated in clusters, including OCT4, NANOG, SOX2, SIN3A, paralleling...
Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, and latter display an extraordinary ability to initiate metastasis. Yet, biological phenomena that trigger shedding CTC clusters a primary cancerous lesion poorly understood. Here, when dynamically labeling breast cancer along progression, we observe majority undergoing hypoxia, while CTCs largely normoxic. Strikingly, find vascular endothelial growth factor (VEGF) targeting leads shrinkage,...
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it unclear whether multicellular CTC clusters generated this disease they can bypass the physical hurdle of blood-brain barrier. Here, we assessed presence composition at multiple time points 13 patients with progressing during an open-label phase 1/2a study microtubule inhibitor BAL101553. We observe...
The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable only minority progressive cancer, and factors that influence the abundance remain elusive. We conducted CTC isolation enumeration selected group 73 consecutive characterized by invasive high load treatment discontinuation at time isolation. were quantified Parsortix microfluidic device. Clinicopathological variables, blood counts detailed history prior...
Abstract Blood-borne metastasis of breast cancer involves a series tightly regulated sequential steps, including the growth primary tumor lesion, intravasation circulating cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each these steps are poorly understood physiologically relevant contexts, owing to rarity experimental models that faithfully recapitulate biology, kinetics, tropism human cancer. Here, we conducted an vivo loss-of-function CRISPR...
Multi-month dispensing (MMD) of antiretroviral therapy (ART) represents one approach differentiated service delivery (DSD) aiming to improve quality and cost-effectiveness for HIV services in resource-limited settings. However, reduction clinic visits people living with (PLWH) should go along out-of-clinic care tailored PLWH`s preferences comorbidities maintain care. eHealth supported MMD offers a potential solution.
Despite tremendous progress in controlling the HIV epidemic sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with (AYPLHIV). Globally, Africa accounts for 85% of AYPLHIV. Overall outcomes along care cascade are worse AYPLHIV as compared all other age groups due various challenges accessing adhering antiretroviral therapy (ART). New, innovative multicomponent packages differentiated service delivery (DSD) models, required address...
This study investigated the scope and nature of complaints, related to unethical behaviour, that have been lodged against South African psychologists with Health Professions Council Africa (HPCSA) between 1990 1999. Certain biographical characteristics complainants their accused also received attention. During this period, complaints were annually approximately 1% psychologists, which 15% resulted indisciplinary inquiries. Only 5% total number 34% disciplinary inquiries led convictions....
<div>Abstract<p>Blood-borne metastasis of breast cancer involves a series tightly regulated sequential steps, including the growth primary tumor lesion, intravasation circulating cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each these steps are poorly understood physiologically relevant contexts, owing to rarity experimental models that faithfully recapitulate biology, kinetics, tropism human cancer. Here, we conducted an <i>in...
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression