A5042450224- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Circadian rhythm and melatonin
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Molecular Biology Techniques and Applications
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Hypothalamic control of reproductive hormones
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Social Policy and Reform Studies
- Advances in Oncology and Radiotherapy
Cancer Research UK Manchester Institute
2017-2023
University of Manchester
2015-2023
ETH Zurich
2021-2023
University of Basel
2020-2021
University Hospital of Basel
2020-2021
Centre National de la Recherche Scientifique
2017-2018
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires
2017-2018
Paris-Est Sup
2017
University of Patras
2007-2012
The perinuclear actin cap is an important cytoskeletal structure that regulates nuclear morphology and re-orientation during front-rear polarisation. mechanisms regulating the are currently poorly understood. Here, we demonstrate STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor, localises at envelope, co-localising with key proteins Nesprin-2G Non-muscle myosin IIB (NMMIIB), where it activity. We show STEF depletion reduces apical cables (a phenotype rescued by targeting...
Abstract Centrosome separation is critical for bipolar spindle formation and the accurate segregation of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) a microtubule motor essential centrosome separation, Tiam1 its substrate Rac antagonize Eg5-dependent in early mitosis promoting efficient chromosome congression. Here we identify S1466 as novel Cdk1 site whose phosphorylation required mitotic function Tiam1. We find that this activation group I p21-activated kinases (Paks) on...
Lung cancer is the leading cause of deaths. Its high mortality associated with metastatic potential. Here, we show that RAC1-selective guanine nucleotide exchange factor T cell invasion and metastasis-inducing protein 1 (TIAM1) promotes migration in most common subtype lung cancer, non-small-cell (NSCLC), through an unexpected nuclear function. We TIAM1 interacts TRIM28, a master regulator gene expression, nucleus NSCLC cells. reveal TIAM1-TRIM28 complex epithelial-to-mesenchymal transition,...
Abstract Blood-borne metastasis of breast cancer involves a series tightly regulated sequential steps, including the growth primary tumor lesion, intravasation circulating cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each these steps are poorly understood physiologically relevant contexts, owing to rarity experimental models that faithfully recapitulate biology, kinetics, tropism human cancer. Here, we conducted an vivo loss-of-function CRISPR...
// Zoi Diamantopoulou 1, * , Maud-Emmanuelle Gilles Maha Sader 1 Mélissande Cossutta Benoit Vallée Claire Houppe Damien Habert Blandine Brissault 2 Eric Leroy Federica Maione 3 Enrico Giraudo Destouches Jacques Penelle José Courty ** and Ilaria Cascone Laboratory of Growth, Reparation Tissue Regeneration (CRRET), University Paris Est, ERL-CNRS 9215, 94010 Créteil, France East Institute Chemistry Materials Science, CNRS & Paris-Est, 94320 Thiais, Department Oncological Sciences Transgenic...
Analogs of GnRH, including [DLeu6, desGly1o]-GnRH-NHEt (leuprolide, commercial product), have been widely used in oncology to induce reversible chemical castration. Several studies provided evidence that, besides their pituitary effects, GnRH analogs may exert direct antiproliferative effects on tumor cells. To study the effect modifications positions 4 and 6 leuprolide prostate cancer cell proliferation, we synthesized 12 new analogs. All lacked carboxy-terminal Gly10-amide an ethylamide...
Abstract Lamprey gonadotropin‐releasing hormone type III (lGnRH‐III) is an isoform of GnRH isolated from the sea lamprey (Petromyzon marinus) with negligible endocrine activity in mammalian systems. Data concerning superior direct anticancer lGnRH‐III have been published, raising questions on structure–activity relationship. We synthesized 21 analogs rational amino acid substitutions and studied their effect PC3 LNCaP prostate cancer cell proliferation. Our results question importance acidic...
Abstract Background Pleiotrophin, also known as HARP (Heparin Affin Regulatory Peptide) is a growth factor expressed in various tissues and cell lines. Pleiotrophin participates multiple biological actions including the induction of cellular proliferation, migration angiogenesis, involved carcinogenesis. Recently, we identified characterized several pleiotrophin proteolytic fragments with activities similar or opposite to that pleiotrophin. Here, investigated P(122-131), synthetic peptide...
A member of the ribonuclease superfamily, human angiogenin (hAng) is a potent angiogenic factor. Heteronuclear NMR spectroscopy combined with induced-fit docking revealed dual binding mode for most antiangiogenic compound series ribofuranosyl pyrimidine nucleosides that strongly inhibit hAng's activity in vivo. While modeling suggests potential simultaneous inhibitors at active and cell-binding sites, studies indicate greater affinity site than site. Additionally, molecular dynamics...
<div>Abstract<p>Blood-borne metastasis of breast cancer involves a series tightly regulated sequential steps, including the growth primary tumor lesion, intravasation circulating cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each these steps are poorly understood physiologically relevant contexts, owing to rarity experimental models that faithfully recapitulate biology, kinetics, tropism human cancer. Here, we conducted an <i>in...
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Supplementary Figure from An <i>In Vivo</i> CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression