A5073572602- Historical and Literary Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Cellular Mechanics and Interactions
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- RNA regulation and disease
- Cancer Cells and Metastasis
- Protein Kinase Regulation and GTPase Signaling
University of Manchester
2020-2024
Cancer Research UK
2020-2024
Cancer Research UK Manchester Institute
2020-2024
University of Sheffield
1984-2022
CRUK Lung Cancer Centre of Excellence
2020
University College London
2020
Lung cancer is the leading cause of deaths. Its high mortality associated with metastatic potential. Here, we show that RAC1-selective guanine nucleotide exchange factor T cell invasion and metastasis-inducing protein 1 (TIAM1) promotes migration in most common subtype lung cancer, non-small-cell (NSCLC), through an unexpected nuclear function. We TIAM1 interacts TRIM28, a master regulator gene expression, nucleus NSCLC cells. reveal TIAM1-TRIM28 complex epithelial-to-mesenchymal transition,...
Summary Viral infection leads to large alterations in the host transcriptome and stimulates an antiviral immune response involving numerous proteins signalling pathways. Long non‐coding RNAs (lncRNAs) have emerged as important regulators during viral infection. Emerging data demonstrates that lncRNAs play essential roles at pathogen interface modulating by either distinct level including recognition receptors or epigenetic, transcriptional, post‐transcriptional effects. Furthermore,...
KRASG12C and KRASG12D inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) in general by directly targeting its most mutated oncoprotein. However, resistance to these small molecules has highlighted the need rational combination partners necessitating critical understanding of signaling downstream KRAS mutant isoforms. We contrasted tumor development between KrasG12C KrasG12D genetically engineered mouse models (GEMMs). To corroborate findings...
Chemoresistance poses a great barrier to breast cancer treatment and is thought correlate with increased matrix stiffness. We developed two-dimensional (2D) polyacrylamide (PAA) three-dimensional (3D) alginate in vitro models of tissue stiffness that mimic the normal cancer. then used these compare cell viability response chemotherapeutic treatment. In both 2D 3D we observed growth size was at higher corresponding tumours compared tissue. When measured, specific differential for gemcitabine...
Abstract Introduction KRAS G12C and G12D inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) in general by directly targeting its most mutated oncoprotein. However, resistance to these small molecules has highlighted the need rational combination partners necessitating critical understanding of signaling downstream mutant isoforms. Methods We contrasted tumor development between Kras genetically engineered mouse models (GEMMs). To corroborate...