Christian Kurzeder
A5090489400- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Clinical practice guidelines implementation
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Reconstructive Surgery and Microvascular Techniques
- Cancer survivorship and care
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Advanced Breast Cancer Therapies
- Economic and Financial Impacts of Cancer
- Cancer and Skin Lesions
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Lymphoma Diagnosis and Treatment
Breast Center
2017-2025
University of Basel
2017-2025
University Hospital of Basel
2018-2025
ETH Zurich
2021
Women's Hospital
2020
Universitäts Frauenklinik
2003-2019
Ospedale San Giovanni Bellinzona
2015
Kliniken Essen-Mitte
2011-2014
Universität Ulm
2004-2011
Essen University Hospital
2011
The ability of circulating tumor cells (CTCs) to form clusters has been linked increased metastatic potential. Yet biological features and vulnerabilities CTC remain largely unknown. Here, we profile the DNA methylation landscape single CTCs from breast cancer patients mouse models on a genome-wide scale. We find that binding sites for stemness- proliferation-associated transcription factors are specifically hypomethylated in clusters, including OCT4, NANOG, SOX2, SIN3A, paralleling...
The aim of that study was to analyze the impact German-S3-breast cancer guideline adherence on clinical outcomes.A retrospective analyzed 3976 patients first diagnosed with primary breast according an S3-guideline-based model classified retrospectively into groups receiving "guideline-adherent and "guideline non-adherent" therapy.There a significant association between treatment prolonged recurrence free overall survival (p = 0.0001). greater number violations in adherence, lower Advanced...
Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients almost a century. In the 1990s, however, and in parallel with advent of sentinel (SLN) procedure, ALND came under increasing scrutiny due to its association significant patient morbidity. Several studies have since provided evidence suggest omission ALND, often favor radiation, selected clinically node-negative, SLN-positive patients, thus supporting current...
Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications post-mastectomy radiation therapy (PMRT) have broadened. The aim of Oncoplastic Breast Consortium initiative was to address relevant questions arising this clinically challenging scenario.A large global panel oncologic, oncoplastic reconstructive surgeons, patient advocates oncologists developed recommendations clinical practice in an iterative...
ABSTRACT The binding of the viral major glycoprotein BLLF1 (gp350/220) to CD21 cellular receptor is thought play an essential role during infection B lymphocytes by Epstein-Barr virus (EBV). However, since CD21-negative cells have been reported be infectible with EBV, additional interactions between and molecules seem probable. Based on a recombinant genomic EBV plasmid, we deleted gene that encodes BLLF1. We tested ability mutant infect different lymphoid epithelial cell lines. Primary...
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. Different signatures were identified using HPV double capture followed next-generation sequencing (NGS) 272 CC patients from BioRAIDs study [NCT02428842]. Correlations clinical, biological molecular...
We developed tailored axillary surgery (TAS) to reduce the tumor volume in patients with clinically node-positive breast cancer point where radiotherapy can control it. The aim of this study was quantify extent load reduction achieved by TAS.
Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read RNA sequencing (scRNA-seq) on clinical samples from three ovarian patients presenting with omental metastasis and increase PacBio depth to 12,000 reads per cell. Our approach captures 152,000 isoforms, which over 52,000 were not previously reported. Isoform-level analysis accounting for non-coding isoforms reveals 20% overestimation protein-coding gene...
Breast, colorectal, ovarian, and endometrial cancers constitute approximately 30% of newly diagnosed cancer cases in Switzerland, affecting more than 12,000 individuals annually. Hundreds these patients are likely to carry germline pathogenic variants associated with hereditary breast ovarian (HBOC) or Lynch syndrome (LS). Genetic services (counseling testing) for susceptibility can prevent many diagnoses deaths through early identification risk management.Cascade screening is the systematic...
CD8+ tumor-infiltrating T cells can be regarded as one of the most relevant predictive biomarkers in immune-oncology. Highly infiltrated tumors, referred to inflamed (clinically "hot"), show favorable response immune checkpoint inhibitors contrast tumors with a scarce infiltrate called desert or excluded "cold"). Nevertheless, quantitative and reproducible methods examining their prevalence within are lacking. We therefore established computational diagnostic algorithm quantitatively measure...
The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable only minority progressive cancer, and factors that influence the abundance remain elusive. We conducted CTC isolation enumeration selected group 73 consecutive characterized by invasive high load treatment discontinuation at time isolation. were quantified Parsortix microfluidic device. Clinicopathological variables, blood counts detailed history prior...
Summary. Conventional metaphase cytogenetics underestimates the frequency of specific chromosome aberrations in B‐cell chronic lymphocytic leukaemia (B‐CLL) as a result very low proliferative activity these cells vitro . New molecular approaches, such fluorescence situ hybridization (FISH) or comparative genomic (CGH), may circumvent this problem, at least part, but techniques are either strongly dependent on knowledge candidate regions detect only unbalanced aberrations. In present study,...
Recombinant adeno-associated virus (AAV) is a promising non-pathogenic vector in the emerging field of gene therapy. For AAV serotype 2 (AAV-2) infection, experimental evidence points to an involvement heparan sulphate proteoglycans (HSPG), but also existence additional receptors. We investigated potential role tetraspanin CD9 AAV-2 infection breast cancer cells mainly because it binds heparin-binding EGF-like growth factor, suggesting that may interact with virus. Among cell lines,...