A5013271239- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Inflammatory Bowel Disease
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Multiple and Secondary Primary Cancers
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
Hôpital Privé Jacques Cartier
2019-2024
Institut Curie
2012-2021
Hôpital René Huguenin
2016-2019
Université Paris Sciences et Lettres
2017-2019
Université de Versailles Saint-Quentin-en-Yvelines
2019
University Hospital of Geneva
2014-2017
Université Paris Cité
2008-2015
Institut Cochin
2009-2015
Centre National de la Recherche Scientifique
2011-2015
Délégation Paris 5
2011-2012
Epidermal growth factor receptor (EGFR) binds transforming alpha (TGF-alpha) which is mitogenic for hepatocytes. Diverse lines of evidence suggest that activation the TGF-alpha /EGFR pathway contributes to hepatocellular carcinoma (HCC) formation. Herein, we developed an experimental model cirrhosis giving rise HCC and tested antitumoral effect gefitinib, a selective EGFR tyrosine kinase inhibitor, in this model. Rats received weekly intraperitoneal injections diethylnitrosamine (DEN)...
<h3>Aims</h3> The activation of β-catenin signalling is a key step in intestinal tumorigenesis. Interplay between the and Notch pathways during tumorigenesis has been reported, but mechanisms involved role remain unclear. <h3>Methods</h3> status was analysed by studying expression effector Hes1 ligands/receptors human colorectal cancer (CRC) mouse models Apc mutation. A genetic approach used, deleting RBP-J or Atoh1 genes murine intestine. CRC cell lines were used to analyse control...
Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches create mouse model with high metastatic potential. Construction analysis this network map depicting molecular mechanisms EMT regulation based on the literature suggests that Notch activation p53 deletion have synergistic effect activating...
BACKGROUND Few data are available on second‐line chemotherapy (CT2) for advanced biliary tract cancer (ABTC). The aim of this multicenter study was to describe the CT2 regimens used, response rates, and outcomes patients treated with various regimens. METHODS Patients who received ABTC at 17 French institutions after failure gemcitabine‐platinum combination were retrospectively studied. Progression‐free survival (PFS) overall (OS) estimated Kaplan‐Meier method. Cox models used multivariate...
Abstract Purpose: Chemoradiotherapy (CRT) is the current standard of care for patients diagnosed with locally advanced anal squamous cell carcinoma (ASCC), but some develop local and/or distant relapse during follow-up. This study was designed to monitor human papillomavirus (HPV) circulating tumor DNA (ctDNA) levels CRT in ASCC. Experimental Design: We analyzed samples from HPV16- or HPV18-positive Blood were collected before and after CRT. HPV16 HPV18 ctDNA detection performed by droplet...
Epidermal growth factor receptor (EGFR)- and type 1 insulin-like (IGF-1R)-dependent pathways are up-regulated in hepatocellular carcinoma (HCC), cross-talks between both have been described other systems. Gefitinib, a specific EGFR inhibitor, has shown to reduce significantly, although not completely, HCC formation rat cirrhotic liver. Here, we investigated whether IGF-1R-dependent may interfere with signalling hepatoma cells and, if so, such affect the antitumoral effect of gefitinib these...
Cyclosporine is an effective rescue therapy in steroid-refractory ulcerative colitis (UC) and may avoid immediate colectomy. However, the individual's response to cyclosporine poorly predictable. The aim of this study was identify predictive factors UC.One hundred thirty-five patients with UC, admitted consecutively between 1992 2004, were included. Data collected on first day therapy. Colonoscopy performed within 2 days preceding or following treatment 118 for assessing presence severe...
Development of targeted therapeutics required translationally relevant preclinical models with well-characterized cancer genome alterations. Here, by studying 52 colorectal patient-derived tumor xenografts (PDX), we examined key molecular alterations the IGF2-PI3K and ERBB-RAS pathways response to cetuximab. PDX data were compared that published for patient tumors in The Cancer Genome Atlas. We demonstrated a significant pattern mutual exclusivity genomic abnormalities pathways. anomaly...
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. Different signatures were identified using HPV double capture followed next-generation sequencing (NGS) 272 CC patients from BioRAIDs study [NCT02428842]. Correlations clinical, biological molecular...
A better understanding of the molecular profile anal squamous cell carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and identification prognostic predictive factors for response treatment. We retrospectively analysed tumours from ASCC patients mutational analysis KRAS, NRAS, HRAS, BRAF, PIK3CA, MET, TP53 FBXW7 genes by HRM Sanger sequencing analysis. Specimens 148 were analysed: 96 treatment-naive 52 recurrences after initial radiotherapy (RT) or chemoradiotherapy...
The prevalence, clinical profiles and management of gastroenteropancreatic endocrine tumours (GEP) in France are not known. From August 1, 2001 to September 2002, standardized records on patients with GEP were prospectively completed 87 participating centres. total group amounted 668 (median age: 56 years, range: 12–89). WHO performance status was 0/1 for 80.2% patients. primary sites the small bowel colon (288), pancreas (211), unknown (77), stomach (33), non-digestive (24), appendix (20),...
A prevalence of around 26% human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involving E6 E7 viral oncoproteins. In some cases, DNA detected to integrate with the host genome possibly contributes carcinogenesis by affecting gene expression. We retrospectively assessed integration sites signatures 80 positive patients HNSCC, using a double capture-HPV method followed next-generation Sequencing. HPV16 90%...
The Arp2/3 complex is required for cell migration and invasion. its activators, such as the WAVE complex, are deregulated in diverse cancers. Here we investigate expression of Arpin, inhibitory protein that antagonises complex.We used qRT-PCR reverse phase arrays a patient cohort with known clinical parameters outcome, immunofluorescence breast biopsy cryosections cancer lines.Arpin was downregulated at mRNA levels mammary carcinoma cells. Arpin downregulation associated poor metastasis-free...