A5032350168- Breast Cancer Treatment Studies
- Ocular Oncology and Treatments
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Cancer Risks and Factors
- Nonmelanoma Skin Cancer Studies
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Estrogen and related hormone effects
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Multiple and Secondary Primary Cancers
- Corneal Surgery and Treatments
- Genomics and Chromatin Dynamics
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
- CNS Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
Université Paris Sciences et Lettres
2018-2025
Institut Curie
2016-2025
Zimmer Biomet (France)
2018-2025
Sorbonne Université
2006-2019
Centre Oscar Lambret
2013-2019
UniCancer Group
2018-2019
Aix-Marseille Université
2019
Institut de Cancérologie de Lorraine
2018
Institut Bergonié
2018
Centre Léon Bérard
2018
The objective of this study was to assess the prevalence and associated factors sexual activity, problems or satisfaction in French early-stage breast cancer survivors (BCS).Eight hundred fifty eligible, post-treatment (6 months-5 years) female patients, aged 18-70 years, randomly selected from a consultation list, were invited fill questionnaires exploring quality life (EORTC QLQ-C30 QLQ-BR23), body image scale, sexuality (Sexual Activity Questionnaire-SAQ; Relationship Sexuality Scale;...
Abstract Background Carboplatin plays an important role in the conservative management of retinoblastoma, but is associated with risk ototoxicity these young children whose sensory prognosis may be also compromised by their loss vision. This retrospective study analyzed impact carboplatin on hearing context retinoblastoma. Methods Data for 175 treated at Institut Curie between 1994 and 2002 were analyzed. Results Median age diagnosis was 8 months (0–60). administered 3 days (200 mg/m 2 /day)...
Abstract Predicting evolution of small node‐negative breast carcinoma is a real challenge in clinical practice. The aim this study was to search whether qualitative or quantitative DNA changes may help predict metastasis carcinoma. Small invasive ductal carcinomas without axillary lymph node involvement (T1T2N0) from 168 patients with either good (111 no event at 5 years after diagnosis) poor (57 early metastasis) outcome were analyzed comparative genomic hybridization (CGH) array. A CGH...
Purpose The objective of this prospective study was to assess overall survival and event-free in patients with intraocular unilateral retinoblastoma (Reese-Ellsworth group V) treated by primary enucleation or without adjuvant therapy depending on histopathologic risk factors. Patients Methods (n = 123) were divided into three groups the basis factors for extraocular relapse metastasis assessed centralized histologic examination enucleated eyes. Group 1 70) had minimal no choroidal...
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. Different signatures were identified using HPV double capture followed next-generation sequencing (NGS) 272 CC patients from BioRAIDs study [NCT02428842]. Correlations clinical, biological molecular...
Although the COVID-19 pandemic peaked in March/April 2020 France, prevalence of infection is barely known. Using high-throughput methods, we assessed herein serological response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1847 participants working three sites an institution Paris conurbation. In May-July 2020, 11% (95% confidence interval [CI]: 9.7-12.6) serums were positive for IgG SARS-CoV-2 N and S proteins, 9.5% CI: 8.2-11.0) neutralizer pseudo-typed virus...
Abstract Histone synthesis and chromatin assembly are mainly associated with DNA replication thus intimately involved in cell cycle regulation. The expression of key components these events human cells was studied relation to cell-proliferative status. Among several factors, factor (CAF)-1 stood out as the most discriminating marker proliferative state. We show, using both immunofluorescence Western blot analysis, that CAF-1 large subunits, p150 p60, is massively down-regulated during...
Mammalian cells contain three closely related heterochromatin protein 1 (HP1) isoforms, HP1alpha, beta and gamma, which, by analogy to their unique counterpart in Schizosaccharomyces pombe, have been implicated gene silencing, genome stability chromosome segregation. However, the individual importance of each isoform during normal cell cycle disease has remained an unresolved issue. Here, we reveal that HP1alpha shows a proliferation-dependent regulation, which neither HP1beta nor gamma...
There is a lack of information as to which molecular processes, present at diagnosis, favor tumour escape from standard-of-care treatments in cervical cancer (CC). RAIDs consortium (www.raids-fp7.eu), conducted prospectively monitored trial, [BioRAIDs (NCT02428842)] with the objectives generate high quality samples and assessments stratify patient populations identify patterns associated poor outcome.Between 2013 2017, collected prospective CC sample clinical dataset involving 419...
To distinguish new primary breast cancers from true recurrences, pangenomic analyses of DNA copy number alterations (CNAs) using single-nucleotide polymorphism arrays have proven useful.The profiles 22 pairs carcinoma (ductal or lobular) and ipsilateral the same patients were analyzed. Hierarchical clustering was performed CNAs breakpoint information. A partial identity score developed information used to quantify identities between two tumors. The nature (true recurrence vs tumor) as...
Human papillomavirus (HPV) DNA sequences are associated with the large majority of invasive cervical carcinoma but role specific genotype(s) in outcome disease is still debated. To determine viral epidemiology French population patients and prognostic value HPV genotypes cancer, we performed a retrospective study 515 treated our Institution from 1985 to 2005. Ninety-six percent cases were found whereas 4% remained negative. High-risk 16/18 70% cases. 18 was more frequently adenocarcinoma...
Abstract BACKGROUND: Usual practices recommend waiting at least 2 years between diagnosis of early breast cancer (EBC) and pregnancy. Few data highlighted a harmful effect an pregnancy for low‐risk patients. The authors analyzed retrospectively from women younger than 35 who became pregnant before or after treatment EBC. METHODS: Between 1990 1999, 908 consecutive EBC patients were analyzed. primary endpoint was to compare overall survival (OS) nonpregnant secondary establish score index...
Polo S E, Theocharis Grandin L, Gambotti Antoni G, Savignoni A, Asselain B, Patsouris E & Almouzni G (2010) Histopathology 57 , 716–724 Clinical significance and prognostic value of chromatin assembly factor‐1 overexpression in human solid tumours Aims: Chromatin (CAF‐1), whose function is critical for maintaining stability during DNA replication repair, has been identified as a proliferation marker breast cancer. The aim was to investigate CAF‐1 wide variety tumours, assess its...