Marc Deloger
A5089810939- Occupational and environmental lung diseases
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Phosphodiesterase function and regulation
- Renal cell carcinoma treatment
- Metastasis and carcinoma case studies
- RNA Research and Splicing
- Cervical Cancer and HPV Research
- Cholinesterase and Neurodegenerative Diseases
- Molecular Biology Techniques and Applications
Institut Gustave Roussy
2015-2024
Institut Curie
2019-2024
Centre National de la Recherche Scientifique
2016-2023
Inserm
2014-2023
Université Paris Sciences et Lettres
2019-2023
École Nationale Supérieure des Mines de Paris
2019-2023
Université Paris-Saclay
2022-2023
ParisTech
2019-2023
Institut Pasteur
2019
Jawaharlal Nehru University
2012
Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic (mBC) is associated with poor outcomes, yet limited information available on profile this disease. This study aims to decipher mutational profiles mBC using next-generation sequencing.Whole-exome sequencing was performed 216 tumor-blood pairs from patients who underwent a biopsy context SAFIR01, SAFIR02, SHIVA, or Molecular Screening for Cancer Treatment Optimization (MOSCATO)...
The mechanisms of action and resistance to trastuzumab deruxtecan (T-DXd), an anti-HER2-drug conjugate for breast cancer treatment, remain unclear. phase 2 DAISY trial evaluated the efficacy T-DXd in patients with HER2-overexpressing (n = 72, cohort 1), HER2-low 74, 2) HER2 non-expressing 40, 3) metastatic cancer. In full analysis set population 177), confirmed objective response rate (primary endpoint) was 70.6% (95% confidence interval (CI) 58.3-81) 1, 37.5% CI 26.4-49.7) 29.7% 15.9-47) 3....
We used next generation sequencing to characterize and compare the genomes of recently derived allotetraploid, Nicotiana tabacum (<200,000 years old), with its diploid progenitors, sylvestris (maternal, S-genome donor), tomentosiformis (paternal, T-genome donor). Analysis 14,634 repetitive DNA sequences in progenitor species N. reveal all major types retroelements found angiosperms (genome proportions range between 17–22.5% 2.3–3.5% for Ty3-gypsy elements Ty1-copia elements, respectively)....
The fundamental unit of biological diversity is the species. However, a remarkable extent intraspecies in bacteria was discovered by genome sequencing, and it reveals need to develop clear criteria group strains within Two main types analyses used quantify variation at level are average nucleotide identity (ANI), which detects DNA conservation core genome, content, calculates proportion shared two genomes. Both estimates based on BLAST alignments for definition sequences common pair....
Abstract Purpose: This single-institutional feasibility study prospectively characterized genomic alterations in recurrent or refractory solid tumors of pediatric patients to select a targeted therapy. Experimental Design: Following treatment failure, with signed consent and ages above 6 months, underwent tumor biopsy surgical resection primary metastatic site. These newly acquired samples were analyzed by comparative hybridization array, next-generation sequencing for 75 target genes,...
Abstract Purpose: Liquid biopsies based on circulating cell-free DNA (cfDNA) analysis are described as surrogate samples for molecular analysis. We evaluated the concordance between tumor (tDNA) and cfDNA a large cohort of patients with advanced or metastatic solid tumor, eligible phase I trial good performance status, enrolled in MOSCATO 01 (clinical NCT01566019). Experimental Design: Blood were collected at inclusion was extracted from plasma 334 patients. Hotspot mutations screened using...
Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but whether how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here, we show that malignant processes can cause ileal mucosa atrophy, villous microvascular constriction dominance sympathetic over cholinergic signaling. The rapid onset tumorigenesis induced a burst REG3γ release by cells, transient epithelial barrier permeability culminated in overt...
Abstract Metastatic relapse after treatment is the leading cause of cancer mortality, and known resistance mechanisms are missing for most treatments administered to patients. To bridge this gap, we analyze a pan-cancer cohort (META-PRISM) 1,031 refractory metastatic tumors profiled via whole-exome transcriptome sequencing. META-PRISM tumors, particularly prostate, bladder, pancreatic types, displayed transformed genomes compared with primary untreated tumors. Standard-of-care biomarkers...
Capture of retroviral envelope genes is likely to have played a role in the emergence placental mammals, with evidence for multiple, reiterated, and independent capture events occurring be responsible diversity present day structures. Here, we uncover full-length endogenous retrovirus protein, dubbed HEMO [human MER34 (medium-reiteration-frequency-family-34) ORF], unprecedented characteristics, because it actively shed blood circulation humans via specific cleavage precursor protein upstream...
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. Different signatures were identified using HPV double capture followed next-generation sequencing (NGS) 272 CC patients from BioRAIDs study [NCT02428842]. Correlations clinical, biological molecular...
Although CD8+ T cells undergo autonomous clonal proliferation after antigen stimulation in vivo, the expansion of activated CD4+ is limited by intrinsic factors that are poorly characterized. Using genome-wide CRISPR-Cas9 screens and an vivo system modeling antigen-experienced cell recruitment during a localized immune response, we identified suppressor cytokine signaling 1 (SOCS1) as major nonredundant checkpoint imposing brake on proliferation. anti–interleukin-2 receptor (IL-2R) blocking...
Alternative splicing and polyadenylation were observed pervasively in eukaryotic messenger RNAs. These alternative isoforms could either be consequences of physiological regulation or stochastic noise RNA processing. To quantify the extent polyadenylation, we analyzed usage sites Entamoeba histolytica using RNA-Seq. First, identified a large number rarely spliced junctions then showed that occurrence these events is correlated with site sequence, constitutive abundance. Our results implied...
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive malignancy that occurs in young women, characterized by recurrent loss-of-function mutations SMARCA4 gene, and for which effective treatments options are lacking. The aim this study was to broaden knowledge on rare reporting a comprehensive molecular analysis independent cohort SCCOHT cases. We conducted Whole Exome Sequencing six SCCOHT, RNA-sequencing array comparative genomic hybridization eight SCCOHT....
Background Cancer stem cells (CSC) define a population of rare malignant endowed with ‘stemness’ properties, such as self-renewing, multipotency and tumorigenicity. They are responsible for tumor initiation progression, could be associated resistance to immunotherapies by negatively regulating antitumor immune response acquiring molecular features enabling escape from CD8 T-cell immunity. However, the immunological hallmarks human lung CSC their potential interactions resident memory T (T RM...
Background: Real-world data (RWD) related to the health status and care of cancer patients reflect ongoing medical practice, their analysis yields essential real-world evidence. Advanced information technologies are vital for collection, qualification, reuse in research projects. Methods: UNICANCER, French federation comprehensive centres, has innovated a unique network: Consore. This potent federated tool enables from millions across eleven hospitals. Results: Currently operational within...
A prevalence of around 26% human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involving E6 E7 viral oncoproteins. In some cases, DNA detected to integrate with the host genome possibly contributes carcinogenesis by affecting gene expression. We retrospectively assessed integration sites signatures 80 positive patients HNSCC, using a double capture-HPV method followed next-generation Sequencing. HPV16 90%...
Cancer immunotherapy combinations have recently been shown to improve the overall survival of advanced mesotheliomas, especially for patients responding those treatments. We aimed characterize biological correlates malignant pleural mesotheliomas' primary resistance and antiangiogenics by testing combination pembrolizumab, an anti-PD-1 antibody, nintedanib, a pan-antiangiogenic tyrosine kinase inhibitor, in multicenter PEMBIB trial (NCT02856425). Thirty with mesothelioma were treated...
Amoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Although primary etiological agent amoebiasis obligate human parasite Entamoeba histolytica, other members genus can infect humans and may be pathogenic. Here, we present first annotated reference genome for moshkovskii, species that has been associated with infections, compare genomes E. commensal dispar, nonhuman pathogen invadens. Gene clustering phylogenetic analyses show differences in expansion...
β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains hemoglobin, leading to accumulation free a-globin that aggregate and cause ineffective erythropoiesis. We have previously demonstrated terminal erythroid maturation requires transient activation caspase-3 chaperone Heat Shock Protein 70 (HSP70) accumulates nucleus protect GATA-1 transcription factor from cleavage. This nuclear HSP70 inhibited human β-TM...
The role of human papillomavirus (HPV) in anal squamous cell carcinoma (ASCC) carcinogenesis has been clearly established, involving the expression viral oncoproteins and optional DNA integration into host genome. In this article, we describe various mechanisms sites HPV insertion assess their prognostic predictive value a large series patients with HPV-positive ASCC long-term follow-up. We retrospectively analyzed 96 tumor samples from 93 using Capture-HPV method followed by Next-Generation...
Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine release was...
Chromatin modifications orchestrate the dynamic regulation of gene expression during development and in disease. Bulk approaches have characterized wide repertoire histone across cell types, detailing their role shaping identity. However, these population-based methods do not capture cell-to-cell heterogeneity chromatin landscapes, limiting our appreciation biological processes. Recent technological developments enable mapping marks at single-cell resolution, opening up perspectives to...