Diane Letourneur
A5037545607- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Chemokine receptors and signaling
- Immune cells in cancer
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 Clinical Research Studies
- Plant Parasitism and Resistance
- Nicotinic Acetylcholine Receptors Study
- Neuroblastoma Research and Treatments
- Plant and animal studies
- Electrospun Nanofibers in Biomedical Applications
- Biochemical and biochemical processes
- Tissue Engineering and Regenerative Medicine
- Echinoderm biology and ecology
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
Université Paris Cité
2022-2024
Institut Pasteur
2022-2024
École Normale Supérieure de Lyon
2019-2023
Inserm
2009-2023
Université Claude Bernard Lyon 1
2022-2023
Institut Gustave Roussy
2020-2023
Université Paris-Saclay
2022
Centre National de la Recherche Scientifique
2022
Laboratoire de Recherche Vasculaire Translationnelle
2015
Sorbonne Paris Cité
2014
Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling technologies 16SrRNA sequencing, we herein report that right-sided colorectal tumors are predominantly populated with Colibactin-producing
Patients with high-risk, nonmuscle-invasive bladder cancer (NMIBC) frequently relapse after standard intravesical bacillus Calmette-Guérin (BCG) therapy and may have a dismal outcome. The mechanisms of resistance to such immunotherapy remain poorly understood. Here, using cell lines, freshly resected human tumors, samples from cohorts patients before BCG therapy, we demonstrate 2 distinct patterns immune subversion upon relapse. In the first pattern, intracellular infection cells induced...
Cancer immunotherapy combinations have recently been shown to improve the overall survival of advanced mesotheliomas, especially for patients responding those treatments. We aimed characterize biological correlates malignant pleural mesotheliomas' primary resistance and antiangiogenics by testing combination pembrolizumab, an anti-PD-1 antibody, nintedanib, a pan-antiangiogenic tyrosine kinase inhibitor, in multicenter PEMBIB trial (NCT02856425). Thirty with mesothelioma were treated...
The coronavirus disease 2019 (COVID-19) pandemic is responsible for an important global death toll from which sub-Saharan Africa (SSA) seems mostly protected. reasons explaining this situation are still poorly understood.We analyzed the correlation between reported COVID-19 data February 14, 2020 and May 18, 2021, demographic, socioeconomic, climatic, diagnostic data, comorbidities in 47 SSA countries. Different databases including WHO center, Our World Data, Bank were used.As of 17, 2%...
ABSTRACT Intratumoral bacteria locally contribute to cellular and molecular tumor heterogeneity that support cancer stemness through poorly understood mechanisms. This study aims explore how Colibactin-producing Escherichia coli (CoPEC) flexibly alters the microenvironment in right-sided colorectal (CRC). Metabolomic transcriptomic spatial profiling uncovered CoPEC colonization establishes a high-glycerophospholipid within is conducive exhaustion of infiltrated CD8 + T cell has lowered...
<div>Abstract<p>Cancer immunotherapy combinations have recently been shown to improve the overall survival of advanced mesotheliomas, especially for patients responding those treatments. We aimed characterize biological correlates malignant pleural mesotheliomas’ primary resistance and antiangiogenics by testing combination pembrolizumab, an anti–PD-1 antibody, nintedanib, a pan-antiangiogenic tyrosine kinase inhibitor, in multicenter PEMBIB trial (NCT02856425). Thirty with...
<p>Differential Gene Expression (DGE) of baseline tumor biopsies between patients with DCB and No DCB.</p>
<p>Cytotoxic response in tumor biopsies of patients with No DCB upon combination treatment.</p>
<p>Further descriptions of tumor immune infiltrates.</p>
<p>Gene expression network analysis.</p>
<p>Gating strategy for flow cytometry analyses of T cells infiltration on tumor biopsies.</p>
<p>Gating strategy for flow cytometry analyses of T cells infiltration on tumor biopsies.</p>
<p>Cytotoxic response in tumor biopsies of patients with No DCB upon combination treatment.</p>
<p>Additional significant differences in circulating chemokines.</p>