A5058289133- Gut microbiota and health
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Veterinary Oncology Research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- Hedgehog Signaling Pathway Studies
- Pharmacological Effects of Natural Compounds
- Infectious Diseases and Mycology
- Cancer, Stress, Anesthesia, and Immune Response
- Underground infrastructure and sustainability
- Escherichia coli research studies
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Gastroesophageal reflux and treatments
- Head and Neck Cancer Studies
- Rheumatoid Arthritis Research and Therapies
- Probiotics and Fermented Foods
- dental development and anomalies
- Gallbladder and Bile Duct Disorders
Lithuanian University of Health Sciences
2021-2025
Centre National de la Recherche Scientifique
2022-2024
Institut Pasteur
2022-2024
Saint Petersburg State Pediatric Medical University
2021
National University Zaporizhzhia Polytechnic
2018
Abstract Helicobacter pylori ( H. ) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role pathophysiology of cancer. The aim study was to explore link between cancer prognosis and mucosal microbial community tumorous adjacent tissue. profile analysed using 16S sequencing (V1–V2 region). Microbial differences were mostly characterized by lower relative abundances tissues. Bacterial outcome data analysis...
Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling technologies 16SrRNA sequencing, we herein report that right-sided colorectal tumors are predominantly populated with Colibactin-producing
Helicobacter pylori and the stomach microbiome play a crucial role in gastric carcinogenesis, detailed characterization of is necessary for better understanding pathophysiology disease. There are two common modalities analysis: DNA (16S rRNA gene) RNA transcript) sequencing. The implications from use one or another sequencing approach on comparability mucosal cancer (GC) poorly studied.To characterize microbiota GC using 16S gene its transcript determine difference bacterial composition.In...
Introduction The rapid emergence of multidrug-resistant bacterial species poses a critical threat by reducing the efficacy antibiotics and complicating infection treatment. Bacteriocins, such as klebicin KvarM, have emerged promising alternatives to traditional due their targeted antimicrobial activity. In this study, we evaluated therapeutic potential Eudragit-coated KvarM in mouse model Klebsiella pneumoniae intestinal colonization, assessing both its effectiveness impact on commensal gut...
Next-generation sequencing technologies have started a new era of respiratory tract research in recent years. Alterations the microbiome between healthy and malignant conditions been revealed. However, composition varies among studies, even similar medical conditions. Also, there is lack complete knowledge about lung–gut interactions lung cancer patients. The aim this study was to explore axis non-small-cell (NSCLC) patients associations microbiota clinical parameters (CRP, NLR, LPS, CD8,...
Canine mammary gland tumors (CMTs) are one of the most prevalent cancers in dogs and a good model for human breast cancer (BC), however gene expression analysis CMTs is scarce. Although divergence genes has been found BC different races, no such research dog's breeds done. The purpose this study was to investigate VEGF-B, VEGF-A, FLT-1, KDR, ERBB2, EGFR, GRB2, RAC1, CDH1 HYAL-1 canine carcinomas, compare levels with clinicopathological parameters analyze disparities between breeds....
Recent studies highlight the presence of bacterial sequences in human blood, suggesting potential clinical significance for circulating microbial signatures. These could presumably serve diagnosis, prediction, or monitoring various health conditions. Ensuring similarity samples before analysis is crucial, especially when combining from different biobanks prepared under varying conditions (such as DNA extraction kits, centrifugation conditions, blood collection tubes, etc.). In this study, we...
<title>Abstract</title> Background Lack of antimicrobial agents is a rising global concern. In this study, we investigated the efficacy specific protein bacteriocin, Klebicin KvarM, in treating <italic>K. pneumoniae</italic>-induced intestinal colonization mouse model, and its effect on commensal gut microbiota. Methods Antimicrobial activity KvarM comparison to conventional antibiotic therapy with ciprofloxacin was tested murine models for pneumoniae</italic> gastrointestinal tract...
ABSTRACT Intratumoral bacteria locally contribute to cellular and molecular tumor heterogeneity that support cancer stemness through poorly understood mechanisms. This study aims explore how Colibactin-producing Escherichia coli (CoPEC) flexibly alters the microenvironment in right-sided colorectal (CRC). Metabolomic transcriptomic spatial profiling uncovered CoPEC colonization establishes a high-glycerophospholipid within is conducive exhaustion of infiltrated CD8 + T cell has lowered...
<h3>Background</h3> Recent achievements have established that the very first years since development of RA are decisive in terms progression pathological process and prediction its remote consequences. This substantiated need to reflect heterogeneity stage RA. First all it concerns early – a time point when is primary exudative phase reversibility significantly higher, because not completely formed autoimmune mechanisms absence pannus. <h3>Objectives</h3> Our aim was establish relationship...