A5073559165- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Biomedical Text Mining and Ontologies
- Musculoskeletal pain and rehabilitation
- Ethics in Clinical Research
- Reproductive Biology and Fertility
- AI in cancer detection
- Silicon Carbide Semiconductor Technologies
- Pain Management and Opioid Use
- Machine Learning in Healthcare
- Global Cancer Incidence and Screening
- Cancer-related cognitive impairment studies
- Pain Management and Placebo Effect
- Ovarian function and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Advancements in Semiconductor Devices and Circuit Design
- Glioma Diagnosis and Treatment
- Health, Medicine and Society
- BRCA gene mutations in cancer
- Reproductive Health and Contraception
- Pediatric Pain Management Techniques
- Cancer Cells and Metastasis
Institut Curie
2018-2024
Sorbonne Université
2012-2019
Hôpital Saint-Antoine
2012-2019
Maternité Port Royal
2019
UniCancer Group
2019
Capgemini (France)
2018
Université Paris Sciences et Lettres
2018
University Hospital of Geneva
2018
Hospices Civils de Lyon
2012-2014
Centre Hospitalier Avranches Granville
2012
Many institutions throughout the world have launched precision medicine initiatives in oncology, and a large amount of clinical genomic data is being produced. Although there been attempts at sharing with community, are still limited. In this context, French task force composed Integrated Cancer Research Sites (SIRICs), comprehensive cancer centers from Unicancer network (one Europe's largest research organization), university hospitals an initiative to improve accelerate retrospective...
Background: Real-world data (RWD) related to the health status and care of cancer patients reflect ongoing medical practice, their analysis yields essential real-world evidence. Advanced information technologies are vital for collection, qualification, reuse in research projects. Methods: UNICANCER, French federation comprehensive centres, has innovated a unique network: Consore. This potent federated tool enables from millions across eleven hospitals. Results: Currently operational within...
Abstract Background To compare RCB (Residual Cancer Burden) and Neo-Bioscore in terms of prognostic performance see if adding pathological variables improve these scores. Methods We analysed 750 female patients with invasive breast cancer (BC) treated neoadjuvant chemotherapy (NAC) at Institut Curie between 2002 2012. Scores were compared global population by BC subtype using Akaike information criterion (AIC), C-Index (concordance index), calibration curves after lymphovascular invasion...
To enable a collective effort that generates new level of UNderstanding CANcer (UNCAN.eu) [Cancer Discov (2022) 12 (11): OF1], the European Union supports creation sustainable platform connects cancer research across Member States. A workshop hosted in Heidelberg gathered experts to identify ongoing initiatives may contribute building this and discuss governance long-term evolution Federated Cancer Data Hub.
Introduction: Five to 10% of breast cancers (BCs) occur in a genetic predisposition context (mainly BRCA pathogenic variant). Nevertheless, little is known about immune tumor infiltration, response neoadjuvant chemotherapy (NAC), pathologic complete (pCR) and adverse events according status. Material Methods: Out 1199 invasive BC patients treated with NAC between 2002 2012, we identified 267 tested for germline variant. We evaluated pre-NAC post-NAC infiltration (TILs). Response was assessed...
To compare the computability of Observational Medical Outcomes Partnership (OMOP)-based queries related to prescreening patients using two versions OMOP common data model (CDM; v5.3 and v5.4) assess performance Greater Paris University Hospital (APHP) tool.We identified information items being relevant for with cancer. We randomly selected 15 academic industry-sponsored urology phase I-IV clinical trials (CTs) launched at APHP between 2016 2021. The criteria (PC) was defined by their...
To apply text mining (TM) technology on electronic medical records (EMRs) of patients with breast cancer (BC) to retrieve the occurrence a pregnancy after BC diagnosis and compare its performance manual curation.The training cohort (Cohort A) comprised 344 age ≤ 40 years old treated at Institut Curie between 2005 2007. Manual curation consisted in manually reviewing each EMR pregnancies. TM first applying keyword filter ("accouch*" or "enceinte," French terms for "deliver*" "pregnant,"...
Immunosurveillance plays an important role in breast cancer (BC) prognosis and progression, can be geared by immunogenic chemotherapy. In a cohort of 1023 BC patients treated with neoadjuvant chemotherapy (NAC), 40% the individuals took comedications mostly linked to aging comorbidities. We systematically analyzed off-target effects 1178 concurrent (classified according Anatomical Therapeutic Chemical (ATC) Classification System) on density tumor-infiltrating lymphocytes (TILs) pathological...
Breast cancer (BC) is the most commonly diagnosed type of and leading cause deaths in women. Smoking principal modifiable risk factor for cancers has a negative influence on long-term survival. We conducted retrospective study consecutive BC survivors seen at follow-up consultations between 3 June 30 October 2019 Institut Curie, Paris, France. behaviors were evaluated prospectively via interviewer-administered questionnaires. The aim this was to describe smoking-related patient care...
La fibromyalgie fait beaucoup parler d'elle et suscite encore débats controverses en 2015. Pourtant, il n'est plus question de remettre cause ce syndrome facilement reconnaissable (même si le diagnostic est aussi posé avec excès). Le modèle biopsychosocial permet comprendre prendre charge façon globale toutes les maladies chroniques évite la mise échec des patients soignants. un fréquent qui touche surtout femmes rapportent douleurs chroniques, diffuses, musculaires, tendineuses et/ou...
Abstract Background Breast cancer (BC) has particular characteristics in young women, with diagnosis at more advanced stages, a poorer prognosis and highly aggressive tumors. In NeoFit, we will use an activity tracker to identify describe various digital profiles (heart rate, physical activity, sleep patterns) women below the age of 45 years on neoadjuvant chemotherapy for BC. Methods NeoFit is prospective, national, multicenter, single-arm open-label study. It include 300 treated...
Abstract Introduction Five to 10% of breast cancers (BCs) occur in a genetic predisposition context (mainly BRCA pathogenic variant). Nevertheless, little is known about immune tumor infiltration, response neoadjuvant chemotherapy (NAC), pathologic complete (pCR) and adverse events according status. Material methods Out 1199 invasive BC patients treated with NAC between 2002 2012, we identified 267 tested for germline variant. We evaluated pre-NAC post-NAC infiltration (TILs). Response was...
Abstract Background Multicenter precision oncology real-world evidence requires a substantial long-term investment by hospitals to prepare their data and align on common Clinical Research processes medical definitions. Our team has developed self-assessment framework support hospital networks measure digital maturity better plan coordinate those investments. From that framework, we PRISM for Cancer Outcomes: PRagmatic Institutional Survey benchMarking. Objectives The primary objective was...
ABSTRACT Background Breast cancer is a complex disease that affects millions of people and the leading cause death worldwide. There therefore still need to develop new tools improve treatment outcomes for breast patients. Electronic Health Records (EHRs) contain wealth information about patients, from pathological reports biological measurements, could be useful towards this end but remain mostly unexploited. Recent methodological developments in deep learning, however, open way developing...
Tobacco use is associated with an increase in breast cancer (BC) mortality. Pathologic complete response (pCR) rate to neoadjuvant chemotherapy (NAC) influenced by tumor-infiltrating lymphocyte (TIL) levels and a better long-term survival outcome. The aim of our study evaluate the impact smoking status on TIL levels, NAC prognosis for BC patients. We retrospectively evaluated pre- post-NAC stromal intra tumoral pCR rates cohort T1-T3NxM0 patients treated between 2002 2012 at Institut Curie....