A5039222717- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
- Cancer-related cognitive impairment studies
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
Masaryk Memorial Cancer Institute
2016-2025
Masaryk University
2015-2024
Central European Institute of Technology – Masaryk University
2018-2021
Národný Onkologický Ústav
2016-2021
Weatherford College
2020-2021
Miroslav Krleža Institute of Lexicography
2021
Central European Institute of Technology
2018-2020
St. Anne's University Hospital Brno
2014-2019
University Hospital Brno
2014-2018
University of Central Florida
2017
The accurate identification of glioblastoma progression remains an unmet clinical need. aim this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy (MRS) values apparent diffusion coefficient (ADC) enable distinguishing tumor recurrence from pseudoprogression. Thirty-nine patients after standard treatment a underwent advanced imaging MRS ADC at time suspected - median was 6.7 months. highest...
The aim of this retrospective study is to provide real-world evidence in glioblastoma treatment and compare overall survival after Stupp's regimen today a decade ago. A current consecutive cohort histologically confirmed irradiated from 1/2014 12/2017 our cancer center was compared with an already published historical control patients treated 1/2003-12/2009. total new 155 analyzed, median age 60.9 years, 61% men, 58 (37%) underwent gross tumor resection. indicated 90 (58%), 65 (42%)...
Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as well secondary develop a result of metastatic spread. Circulating microRNAs (miRNAs) were found in almost all human body fluids including cerebrospinal fluid (CSF), and they seem to be highly stable resistant even extreme conditions. The overall aim our study was identify specific CSF miRNA patterns could differentiate among brain tumors. These new biomarkers potentially aid borderline or...
Abstract The prevalence of second primary malignancies (SPMs) in the western world is continually increasing with risk a new cancer patients previously diagnosed carcinoma at about 20%. aim this retrospective analysis to identify SPMs colorectal single-institution cohort, describe most frequent patients, and discover time period occurrence tumors. We identified 1174 2003–2013, follow-up till 31.12.2018, median 10.1 years, (median age 63 724 men). A neoplasm was 234 (19.9%). Older those...
Accelerated partial breast irradiation (APBI) represents a valid option for adjuvant therapy of selected early cancer (BC). This single-institution prospective randomized study compares the health-related quality life (HRQoL) between women treated with highly conformal-external beam APBI technique and those more commonly used moderately hypofractionated whole (hypo-WBI). Eligible patients were over 50 years BC (G1/2 DCIS ≤ 25 mm or G1/2 invasive non-lobular luminal-like HER2 negative...
Objective . To prospectively determine institutional cut-off values of apparent diffusion coefficients (ADCs) and concentration tissue metabolites measured by MR spectroscopy (MRS) for early differentiation between glioblastoma (GBM) relapse treatment-related changes after standard treatment. Materials Methods Twenty-four GBM patients who received gross total resection adjuvant therapy underwent MRI examination focusing on the enhancing region suspected tumor recurrence. ADC maps,...
The prognosis of glioblastoma remains unfavorable. TTFields utilize low intensity electric fields (frequency 150-300 kHz) that disrupt cellular processes critical for cancer cell viability and tumor progression. are delivered via transducer arrays placed on the patients' scalp. Methods: Between years 2004 2022, 55 patients (20 female), aged 21.9-77.8 (mean age 47.3±11.8 years; median 47.6 years) were treated with newly-diagnosed GBM, compared to 54 control females), 27.0-76.7 51.4±12.2 51.7...
Abstract Background To determine the benefit of contrast-enhanced ultrasound (CEUS) in assessment breast lesions. Methods A standardized was performed 230 lesions classified as BI-RADS category 3 to 5. All were subjected qualitative and quantitative analysis. MVI (MicroVascular Imaging) technique used derive analysis parameters; blood perfusion assessed (perfusion homogeneity, type vascularization, enhancement degree). Quantitative conducted estimate changes within drawn regions interest...
Pathological complete response (pCR) achievement is undoubtedly the essential goal of neoadjuvant therapy for breast cancer, directly affecting survival endpoints. This retrospective study 237 triple-negative cancer (TNBC) patients with a median follow-up 36 months evaluated role adding platinum salts into standard chemotherapy (NACT). After initial four NACT cycles, early clinical (ECR) was assessed and used to identify tumors generally sensitive NACT. BRCA1/2 mutation, smaller unifocal...
Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although central nervous system has been traditionally considered an immunologically privileged site with enhanced immune response, GBM appears benefit from this immunosuppressive milieu. Immunomodulatory molecules play important role in tumor-host interactions. Non-classical leukocyte antigens (HLA) class Ib HLA-E, HLA-F, and HLA-G have previously described be involved protecting semi-allogeneic...
The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by 1H-MR spectroscopy focused on hippocampus. Patients with metastases underwent whole radiotherapy (WBRT) dose 30 Gy in ten fractions daily. Pre-radiotherapy h-tNAA concentration testing was performed. Memory...
Head and neck cancers are a heterogenous group of epithelial tumors represented mainly by squamous cell carcinomas (HNSCC), which the sixth most common type cancer worldwide. Surgery together with radiotherapy (RT) is among basic treatment modalities for HNSCC patients. Various biomarkers aiming to predict patients' response RT currently investigated. The reason behind this effort is, on one hand, distinguish radioresistant patients that show weak benefit from and, other reduce ionizing...
Abstract Background Accelerated partial breast irradiation (APBI) is an alternative breast-conserving therapy approach where radiation delivered in less time compared to whole (WBI), resulting improved patient convenience, toxicity, and cost savings. This prospective randomized study compares the external beam APBI with commonly used moderate hypofractionated WBI terms of feasibility, safety, tolerance, cosmetic effects. Methods Early cancer patients after mastectomy were equally into two...
Chemotherapy with lomustine is widely considered as standard treatment option for progressive glioblastoma. The value of adding radiotherapy to second-line chemotherapy not known.
Abstract Background Glioblastoma (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists a combination surgery subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative therapy involves irradiation, magnetic resonance imaging (MRI) used for radiotherapy planning. Unfortunately, in some cases, very early worsening (progression) return (recurrence) disease observed several weeks after called rapid progression...