A5087364903- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- RNA modifications and cancer
- Meningioma and schwannoma management
- Renal cell carcinoma treatment
- Multiple Myeloma Research and Treatments
- Management of metastatic bone disease
- RNA regulation and disease
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Molecular Biology Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Medicinal Plant Pharmacodynamics Research
- Extracellular vesicles in disease
- Radiopharmaceutical Chemistry and Applications
- Chromatin Remodeling and Cancer
- Infectious Encephalopathies and Encephalitis
- Metabolomics and Mass Spectrometry Studies
- MXene and MAX Phase Materials
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Surgical Treatments
- Advanced Radiotherapy Techniques
Central European Institute of Technology
2015-2025
Central European Institute of Technology – Masaryk University
2017-2025
Masaryk University
2016-2024
Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as well secondary develop a result of metastatic spread. Circulating microRNAs (miRNAs) were found in almost all human body fluids including cerebrospinal fluid (CSF), and they seem to be highly stable resistant even extreme conditions. The overall aim our study was identify specific CSF miRNA patterns could differentiate among brain tumors. These new biomarkers potentially aid borderline or...
ABSTRACT Multiple myeloma is a plasma cell malignancy characterized by an abnormal increase in monoclonal immunoglobulins. Despite significant advances treatment, some patients progress to more aggressive forms of multiple myeloma, including extramedullary disease or leukemia. Although the exact molecular mechanisms are not known, several studies have confirmed involvement small extracellular vesicle‐enriched microRNAs progression. Therefore, we performed expression profiling these molecules...
Multiple myeloma (MM) represents the second most common hematological malignancy characterized by infiltration of bone marrow plasma cells that produce monoclonal immunoglobulin. While quality and length life MM patients have significantly increased, remains a hard-to-treat disease; almost all relapse. As is highly heterogenous, relapse at different times. It currently not possible to predict when will occur; numerous studies investigating dysregulation non-coding RNA molecules in cancer...
Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) contribute to its resistance adjuvant treatment. MicroRNAs (miRNAs) small, non-coding RNAs controlling gene expression at post-transcriptional level, which known be important regulators features. Moreover, miRNAs have been previously proved promising diagnostic biomarkers in several cancers including GBM. Using global analysis 10 paired in-vitro as well in-vivo characterized primary...
Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although central nervous system has been traditionally considered an immunologically privileged site with enhanced immune response, GBM appears benefit from this immunosuppressive milieu. Immunomodulatory molecules play important role in tumor-host interactions. Non-classical leukocyte antigens (HLA) class Ib HLA-E, HLA-F, and HLA-G have previously described be involved protecting semi-allogeneic...
Associated with the pathogenesis of many cancers, including brain tumors, microRNAs (miRNAs) present promising diagnostic biomarkers. These molecules have been also studied in cerebrospinal fluid (CSF), showing great potential as a tool patients tumors. Even though there are some biological and technological factors that could affect results their clinical interpretation, miRNA analysis CSF is not fully standardized. This study aims to compare several RNA extraction quantification...
Glioblastoma (GBM) is regarded as an aggressive brain tumor that rarely develops extracranial metastases. Despite well-investigated molecular alterations in GBM, there a limited understanding of these associated with the metastatic potential. We herein present case report 43-year-old woman frontal GBM primitive neuronal component who underwent gross total resection followed by chemoradiation. Five months after surgery, patient was diagnosed intraspinal metastasis. Next-generation sequencing...
Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques chemotherapy, median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure considered presence cells resistant to conventional therapy, mainly radiotherapy. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators gene expression have been...
Multiple myeloma (MM) is the second most prevalent hematological malignancy, characterized by infiltration of bone marrow malignant plasma cells. Extramedullary disease (EMD) represents a more aggressive condition involving migration subclone cells to paraskeletal or extraskeletal sites. Liquid biopsies could improve and speed diagnosis, as they can better capture heterogeneity while lowering patients' discomfort due minimal invasiveness. Recent studies have confirmed alterations in proteome...
BACKGROUND AND OBJECTIVES: Meningioma, the most common primary intracranial tumor, presents challenges in surgical treatment because of varying tissue stiffness. This study explores molecular background meningioma stiffness, a critical factor planning and prognosis, focusing on utility microRNAs (miRNAs) as diagnostic biomarkers METHODS: Patients with meningiomas treated surgically at University Hospital Brno were included this study. Total RNA, isolated from tumor samples, underwent quality...
Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it necessary to deeply understand molecular mechanisms gliomagenesis and identify new potential biomarkers therapeutic targets. PIWI-interacting RNAs (piRNAs) help in maintaining genome stability, their deregulation has already been observed many tumors. Recent studies suggest that these molecules could also play an important role glioma biology. determine...
Brain metastases (BMs) are the most frequent intracranial tumors in adults and one of greatest challenges for modern oncology. Most derived from lung, breast, renal cell, colorectal carcinomas melanomas. Up to 14% patients diagnosed with BMs unknown primary, which commonly characterized by an early aggressive metastatic spread. It is important discover novel biomarkers identification BM origin, allowing better management this disease. Our study focused on microRNAs (miRNAs), very stable...
Current progress in the field of next-generation transcriptome sequencing have contributed significantly to study various malignancies including glioblastoma multiforme (GBM). Differential transcriptomes patients and non-tumor controls has a potential reveal novel transcripts with significant role GBM. One such candidate group molecules are long non-coding RNAs (lncRNAs) which been proved be involved processes as carcinogenesis, epigenetic modifications resistance therapeutic approaches. To...
<title>Abstract</title> Background Febrile seizures are the most common type of convulsions in children. Fever is induced by cytokines release during infection. Recent studies focusing on identification a possible role pathogenesis febrile have contributed conflicting results. Moreover, these investigated only few cytokines, such as IL-1β, IL-6 and TNFα. The aim this study was to investigate multiple cytokine-chemokine profiles that could be potentially associated with development seizures....
Abstract OBJECTIVES Complex local treatment of BM combining surgical resection and radiosurgery provides the possibility adequate control while maintaining a satisfactory quality life. METHODS Patients after postoperative radiotherapy treated between 2007-2023 were evaluated. Local was assessed separately at site operated MM (localPFS) in other parts brain (distalPFS). RESULTS A total 158 patients enrolled (70 with WBRT), 56% women, median age 61 years, performance status Karnofsky 78%. The...
Abstract Bladder cancer is the most common of urinary tract. More than 90% bladder cancers are urothelial carcinoma, which divided into non-muscle-invasive and muscle-invasive forms. Non-muscle-invasive tumors frequently recur (50-70%) can also progress to invasion form (10-15%). These patients monitored by cystoscopy may have multiple resections over many years. Improved monitoring method needed, ideally via urine analysis, could reduce morbidity costs associated with long follow up....
Abstract Introduction: Glioblastoma multiforme (GBM) is the most frequent primary brain tumor of astrocytic origin characterized by very poor prognosis. Despite conventional therapeutic protocol prognosis GBM patients with median overall survival ranging between 12 and 15 months from diagnosis. Therefore, many financial charges lot effort spent in research new approaches that could prolong patients. Long non-coding RNAs (lncRNAs) are a relatively class noncoding gene regulators playing...
Abstract Introduction. Incidence rate of primary brain tumors and metastases counts yearly around 40 patients per 100 000 persons in the world is still growing. Prognosis therapy differs between tumor types and, therefore, accurate early diagnosis might improve survival life quality patients. However, current diagnostic approaches are limited by localization tissue heterogeneity tumors. Cerebrospinal fluid (CSF) bathes central nervous system (CNS) thus supposed to reflect all pathological...