Lenka Součková
A5051661862- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Education, Psychology, and Social Research
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- Meta-analysis and systematic reviews
- Neuroendocrine Tumor Research Advances
- Health and Medical Research Impacts
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Ethics in Clinical Research
- Pancreatic and Hepatic Oncology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotic Resistance in Bacteria
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Misinformation and Its Impacts
- Medical Imaging Techniques and Applications
- Clinical Nutrition and Gastroenterology
- Innovations in Medical Education
- Cancer Treatment and Pharmacology
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
Masaryk University
2014-2025
University Hospital Brno
2016-2025
St. Anne's University Hospital Brno
2012-2025
Saint Anne's Hospital
2023
CESNET, zájmové sdružení právnických osob
2022-2023
Global Development Network
2023
Health Net
2023
European Clinical Research Infrastructure Network
2020-2022
Brno University of Technology
2022
International Clinical Research Center, St. Anne's University Hospital Brno
2018-2019
We conducted a multicentre hospital-based test-negative case–control study to measure the effectiveness of adapted bivalent COVID-19 mRNA vaccines against PCR-confirmed SARS-CoV-2 infection during Omicron XBB lineage-predominant period in patients aged ≥ 60 years with severe acute respiratory from five countries Europe. Bivalent provided short-term additional protection compared those vaccinated > 6 months before campaign: 80% (95% CI: 50 94) for 14–89 days post-vaccination, 15% −12 35)...
The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases provide efficient remedies for citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For reason, University Hospital Cologne a volunteer registry participation in first Germany, which now been incorporated into European...
Introduction The I-MOVE-COVID-19 and VEBIS hospital networks have been measuring COVID-19 vaccine effectiveness (VE) in participating European countries since early 2021. Aim We aimed to measure VE against PCR-confirmed SARS-CoV-2 patients ≥ 20 years hospitalised with severe acute respiratory infection (SARI) from December 2021 July 2022 (Omicron-dominant period). Methods In both networks, 46 hospitals (13 countries) follow a similar test-negative case–control protocol. defined complete...
The inconsistent European vaccine trial landscape rendered the continent of limited interest for developers. VACCELERATE consortium created a network capable clinical sites throughout Europe. identifies and provides access to state-of-the-art accelerate development vaccines.Login details Site Network (vaccelerate.eu/site-network/) questionnaire can be obtained after sending an email to. Interested provide basic information, such as contact details, affiliation with infectious disease...
We estimated the effectiveness of adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during BA.2.86/JN.1 lineage-predominant period using a multicentre test-negative case-control study in Europe. included older adults (≥ 65 years) hospitalised with severe acute respiratory infection from November 2023 to May 2024. Vaccine was 46% at 14-59 days and 34% 60-119 days, no effect thereafter. The conferred protection BA.2.86 lineage first 4 months post-vaccination.
Investigator-initiated trials (IITs) bridge the gap between applied clinical research and everyday practice. However, they require skilled multidisciplinary teams from different backgrounds but all with trial training to ensure are designed, conducted reported according best practice regulatory standards. The availability of trainings fulfil these needs is limited. CONSCIOUS II project facilitated expand supply such programmes. objective describe curriculum designed for PhD students...
Abstract Background Academic-sponsored trials for rare diseases face many challenges; the present paper identifies hurdles in set-up of six multinational clinical drug repurposing, as use cases. Methods Six academic-sponsored aiming to generate knowledge on repurposing were used examples identify problems their set-up. Coordinating investigators leading these provided feedback linked study, country, and site set up, basis pre-identified categories established through analysis previous...
ABSTRACT We conducted a multicentre test‐negative case–control study covering the period from October 2023 to January 2024 among adult patients aged ≥ 18 years hospitalised with severe acute respiratory infection in Europe. provide early estimates of effectiveness newly adapted XBB.1.5 COVID‐19 vaccines against PCR‐confirmed SARS‐CoV‐2 hospitalisation. Vaccine was 49% overall, ranging between 69% at 14–29 days and 40% 60–105 post vaccination. The conferred protection hospitalisation first...
Abstract Background Glioblastoma (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists a combination surgery subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative therapy involves irradiation, magnetic resonance imaging (MRI) used for radiotherapy planning. Unfortunately, in some cases, very early worsening (progression) return (recurrence) disease observed several weeks after called rapid progression...
Background The pan-European VACCELERATE network aims to implement the first transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry point for potential volunteers of large-scale trials across Europe. This work exhibits set trial–related educational promotional tools general public, designed disseminated by network. Objective study primarily aimed design develop standard toolkit increase positive attitudes access trustworthy information better increased...
Despite efforts to develop novel treatment strategies, refractory and relapsing sarcoma high-risk neuroblastoma continue have poor prognoses limited overall survival. Monocyte-derived dendritic cell (DC)-based anti-cancer immunotherapy represents a promising modality in these neoplasias. A DC-based vaccine was evaluated for safety an academic phase I/II clinical trial children, adolescent young adults with progressive, recurrent or primarily metastatic tumors, mainly sarcomas neuroblastomas....
Abstract Background Enteral nutrition is part of the treatment critically ill patients. Administration enteral may be associated with signs intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding effects mode administration on occurrence these complications have yielded conflicting results. This trial aims to investigate whether affects time reach nutritional targets, complications. Methods COINN a randomized, monocentric study for adult patients...
We conducted a multicentre test-negative case-control study covering the period from October 2023 to January 2024 among adult patients aged ≥18 years hospitalised with severe acute respiratory infection in Europe. provide early estimates of effectiveness newly adapted XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation. Vaccine was 48% overall, ranging between 68% at 14–29 days and 40% 60–105 post vaccination. The conferred protection hospitalisation first 3.5 months...
Cardiogenic shock (CS) is a devastating and fatal complication of acute myocardial infarction (AMI). CS can affect the pharmacokinetics pharmacodynamics medications. The unique properties cangrelor make it optimal P2Y12 inhibitor for CS-AMI, in terms both efficacy safety. DAPT-SHOCK-AMI trial (ClinicalTrials.gov: NCT03551964; EudraCT: 2018-002161-19) will assess benefits patients with an initial CS-AMI undergoing primary angioplasty. This randomised, multicentre, placebo-controlled...
The growing demand for polymer composites and their widespread use is inevitably accompanied by the need to know degradation behavior over a sufficiently long period of time. This study focuses on commercial glass fiber rovings, which were stored in indoor environment up 11 years. Fibers with different storage times, from fresh oldest, used produce unidirectional fiber-reinforced polyester that characterized determine shear flexural properties dependent A significant decrease strength was...
Introduction Two large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021. Aim We aimed to measure VE PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients ≥ 20 years, combining data from these during Alpha (March–June)- and Delta (June–December)-dominant periods, Methods Forty-six participating hospitals across 14 countries follow a similar generic protocol using the test-negative case–control...
Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy, who are not eligible for resective epilepsy surgery. In VNS therapy, the responder rate (i.e., percentage of subjects experiencing ≥50% seizure reduction) is ~50%. At moment, there no widely-accepted possibility to predict efficacy a particular patient based on pre-implantation data, which lead unnecessary surgery and improper allocation financial resources. The principal aim PRediction vagal EfficaCy...
Underserved and hard-to-reach population groups are under-represented in vaccine trials. Thus, we aimed to identify the challenges of trial participation these member countries VACCELERATE network. Seventeen National Coordinators (NC), each representing their respective country (15 European countries, Israel, Turkey), completed an online survey. From 15 eligible groups, those that were more frequently declared underserved/hard-to-reach research ethnic minorities (76.5%), persons experiencing...
Abstract Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists a combination surgery subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative therapy involves irradiation, magnetic resonance imaging (MRI) used for radiotherapy planning. Unfortunately, in some cases, very early worsening (progression) return (recurrence) disease observed several weeks after called rapid...
Background and objective Subpleural located pulmonary nodules are perioperatively invisible to the surgeon. Their precise identification is conventionally possible by palpation, but often at cost of performing a thoracotomy. The aim study was evaluate success rate feasibility pre-operative CT-guided marking subpleural localized nodule using mixture Patent Blue V an iodine contrast agent prior extra-anatomical video-assisted thoracoscopic surgery (VATS) resection in patients for whom primary...
Selvekerová, Šárka; Hanáková, Michaela; Demlová, Regina; Nebeská, Kateřina; Krist, Helena; Dušek, Martin; Puškařová, Naděžda; Nevolová, Pavla; Brandejsová, Petra; Doležalová, Hana; Cvikliková, Karin; Krempová, Johana; Součková, Lenka